Pre-Treatment Biopsy - February 19, 1998
sections of liver incorporate portions of several portal triads. These
are expanded and ill-defined, due to increased fibrosis and a polymorphous
infiltrate of lymphocytes and plasma
cells. Focal bridging fibrosis is present, a feature best appreciated on the Trichrome stained sections. There is entrapment of small aggregates of hepatocytes within inflammatory and fibrous elements along limited plates, and in some areas a suggestion of micronodular architecture bordering upon cirrhosis. The hepatocytes show mild generalized fatty infiltration with somewhat variable distribution, and a patchy parenchymal cellular infiltrate of monouclear cells. No abnormal iron deposition is demonstrated on iron
stained sections. There is no evidence of malignancy in the material submitted.
PERCUTANEOUS NEEDLE BIOPSY -- ACTIVE CHRONIC HEPATITIS WITH PERIPORTAL
INTERPORTAL FIBROSIS (HEPATITIS C DISEASE CLINNICALLY)
2 years, I went on 22 months of treatment, starting with mono-therapy with
Intron A for 4 months. I did not respond. I then went directly into Rebetron
treatment for 1 year. Again I did not respond. After a 2 month break in
treatment, I began INFERGEN high dosage daily treatment. I was forced to
stop INFERGEN because my body couldn't handle it. Again, I did not respond.
We had hoped that the treatment would at least stop or slow the progression
of the liver disease.***
Post-Treatment Biopsy - April 13, 2000
MICROSCOPIC: Sections of core needle biopsy of liver show mild portal fibrosis with dense lymphoplasmacytic infiltrates of triads and focal piecemeal entrapment of necrotic hepatocytes. There is septal fibrosis. The bile ducts are recognized lined by recognizable cubiodal epithelium. Some hepatocytes contain large vacuoles of lipid material.
- Iron - Negative
Trichrome - Positive for portal and septal fibrosis.
PAS - Confirmatory of macrovaculor steatosis, moderate and additional H&E findings, negative for malignancy.
DIAGNOSIS: LIVER, CORE BIOPSY: CHRONIC ACTIVE HEPATITIS C WITH FOCAL PIECEMEAL NECROSIS (GRADE 2) AND BRIDGING FIBROSIS WITH ARCHITECTURAL DISTORTION (STAGE 3).