It has been 2 years since the events in Scream....Sidney (Neve Cambell) is now going to college and has another boyfriend (Jerry O' Connell), and Randy (Jamie Kennedy) is along with her. Sidney also has some new friends. (Sarah Michelle Gellar, Elise Neal) Gale Weathers (Courtney Cox) wrote a book on the events that had taken place in the original Scream called "Woodsburo Murders". A movie also has been made based on the book called "Stab". Debbie Salt is a local journalist, (Laurie Metcalf)and Gale's new camera-boy is Joel (Duane Martin.) Cotton Weary (Liev Schreiber), the wrongly accused murderer in the first Scream, has been released from prison. Dewey (David Arquette) has given up his role as Deputy of Woodsburo, and is now visiting Sidney's college to keep an eye on things. All seems well, but when another psycho killer immitates the original killer's moves, Sidney's friends start dropping off like flies. She suspects Cotton again. But is it???? Could it be her boyfriend? Randy? Trust no one!