Ike - Kyle's younger brother.

Ms. Crabtree - schoolbus driver, always running late.

Officer Barbrady - local police officer who always covers things up (black helicopters, Japanese mafia, etc.).

Mr. Garrison - the children's teacher, possible closet homosexual, has multiple personality syndrome- other personality is Mr. Hat 

Mr. Hat - Mr. Garrison's puppet.

Wendy Testaburger - smart, Stan's love interest.

Ms. Cartman - Cartman's mom, appeared on the cover of Crackwhore magazine.

Uncle Jimbo - Stan's uncle.

Ned - Jimbo's old war buddy, missing an arm and vocal cords.

The Mayor - an image-obsessed mayor of South Park.
 
Chef's Sluts - chef's sluts.
 
The Cows - the smartest beings on earth according to the visitors.

Jesus - the Lord, has his own dial-in talk TV show called "Jesus and Pals", fights with Santa Claus in "The Spirit of Christmas".  As a baby, he killed Frosty with his halo.