"Marcelo Hermes-Lima has written an extensive, detailed and up-to-date review of free radicals and their role in biology and disease (Chapters 12 and 13). The coverage is exhaustive. The autor discusses not only reactive oxigen species (ROS) and reactive nitrogen species (RNS) but also sulfur- and carbon-based radicals. Typics include the mechanisms by which diferent types of free radicals are procuced, the biological defenses against ROS (enzymes like superoxide dismutase, catalase, and peroxidase; glutathione; thioredoxin; vitamins C and E; plant polyphenols), the damage caused by oxidation of lipids, proteins, and DNA, the diseases associated with oxidative damage (Wilson's disease, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, atherosclerosis), and the role of free radicals in phagocytosis."
Dr. Harry Schachter (Hospital fod Sick Children, Toronto)
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"Dear Marcelo, I want to congratulate you on the great scope of those chapters and on their thoroughness.
You have done a great job and will thereby contribute the introduction of succeeding generations to this field. My hat is off to you. Sincerely, Irwin (friedovich@biochem.duke.edu)
Dr. Irwin Fridovich (descobridor po papel dos radicais livres em medicina)
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"Dear Marcelo, in the meantime i had a chance to read through your chapters. My congratulatons again. You did a great job! Thanks also for putting our work into a good perspective. Best wishes, Helmut (sies@uni-duesseldorf.de"
Dr. Helmut Sies, Institute for Biochemistry and Molecular Biology I, Dusseldorf, Germany