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4. M.E. vs Depression, M.E. vs FM



1)** Following are two charts
comparing M.E. with depression, and
M.E. & F.M.  Following those two charts, is
a third chart showing the severity and  duration of
M.E. & F.M.  These charts are the best
summarization of all materials I could find. 
"M.E. only" and "F.M. only" are compared here,
as 75% of M.E. patients have F.M. as well;
however only 5% of F.M. patients have M.E. 
The distinctions between M.E. & F.M. may
sometimes be "fuzzy".  These comparisons are in
general terms; M.E. or F.M. can start from young
children up to those 80 years of age.  (#92055
Video2 @6:41); (#92056 Video3@3:10).  M.E. &
F.M. are not the same as depression.  It is very
important that a diagnosis be done by a doctor who
is familiar with M.E. or F.M., as there are many
people who do not have these illnesses,  but have
been diagnosed with it.  This does great harm to
those that actually have it.  An extensive
investigation must be done to ensure that you do
not have another major illness. 

2)** Written psychological tests  show
the differences between M.E. and depression quite
clearly - eg "Do you feel like doing things during
the day?"  For an M.E. patient, the answer would
be "Yes, I feel like doing things even though I am
not physically able to and/or I don't pace myself
and then do too much"; for a depressed person, the
answer would be "No, I don't feel like doing
anything during the day, even though I may be
physically capable of doing something."


Comparison of M.E. and Depression

M.E. ONLY

DEPRESSION ONLY (#92033-19) (#93001)

1. ** SPECT scans done after exercise show an a decrease in brain activity (#91022 Video 1@1:50) #94024-12; #940805-17; #94009-1. Dr . Ishmel Mena & Dr. Jay Goldstein, Dr. Anthony Komaroff #950301-5 1. ** SPECT scans done after exercise show an increase in brain activity, as is expected of the normal functioning brain
2. Exercise makes the patient feel worse with an increase of symptoms often for days, sometimes starting 24-48 hours after. 2. Exercise seems to help the depressed person with sleep and other symptoms. (#940805-21 )
3. M.E. patients are generally well-adjusted, but are tired of being sick and have high motivation. 3. Depressed patients commonly have problems with life, family, or society and have low motivation (#940805-21 )
4. ** Antidepressants in low, medium or high dosages seem to do very little to alleviate the M.E. symptoms, and most patients have intolerance to many drugs. These are usually effective at a very low dose, which is not effective on depression but works on muscle pain, sleep and headaches. 4. ** Anti-depressants seem to help most depressed patients. Lower dosages have little effect.
5. M.E. patients have alcohol intolerance. 5. Depressed patients have no alcohol intolerance, with some patients suffering from alcoholism.
6. Rivotril in low dosages (1 mg) helps with night sweats and sleeping problems. 6. Rivotril in low dosages has little or no effect.
7. M.E. has many specific symptoms 7. Depression may cause a few, but not all of these specific symptoms
8. Strong sleeping pills do little to keep M.E. patients asleep through the night, with patients waking up unrefreshed. 8. Strong sleeping pills seem to help with sleeping problems
9. **Cortisol levels in urine samples are abnormally low . #941101-13 (#92055 Video2@6:42) 9. ** Cortisol levels in urine samples are abnormally high . #941101-13
10. ** Headaches are far more debilitating, repetitive, and almost unstoppable with medication. 10. ** Headaches are as in the general population (#940806-8)
11. ** Patients have been tested for brain wave activity using EEG's (#940805-18) during awake and asleep periods. While awake, sleep waves are being produced, and while asleep, awake waves are being produced. Dr. Cheney, Dr. Lapp (#92055 Video2@7:14) 11. ** Sleep waves are normal .
12. ** Short-term memory proved to be significantly reduced in a study of 150 M.E. patients. Memorization cues proved worthless. #94009-6; #940805-14 & 21. Memorization significantly impaired by brief interruption. 12. ** Study compared depressed and normal people. Both categories had no effect in short-term memory loss . Memorization cues helped. (#940805-14) Memorization not impaired by brief interruption.
13. ** Cognitive or brain functions are impaired. 13. ** Little cognitive problems
14. **M.E. patients tend to over-estimate their abilities on cognitive psychological tests. 14. ** Depressed patients tend to under-estimate their abilities on cognitive tests. (#940805-21)
15. ** M.E. has definite immune abnormalities, proven in many studies, and by the National Institute for Allergies and Infectious Diseases (NIAID) #93016-2; #93014-5 . (#93052 Video4@0:30) 15. ** Depressed patients have few immune abnormalities.
16. ** Symptoms not common to depression: mild fever, sore throat, painful or swollen lymph nodes, unexplained generalized muscle weakness, muscle pain, sudden onset, neurological disturbances and many otbers . 16. **Depressed patients do not have the large number of specific symptoms that M.E. people do.
17. ** High motivation 17. ** Low motivation




COMPARISON OF M.E. & F.M.

M.E. only #92028-53

F.M. Only #90046

1. 75% of M.E. patients have fibromyalgia symptoms l. ** A person may have Fibromyalgia but not have M.E.; about 5% of F.M. patients have M.E. as well.
2 . ** 60% - 70% of M.E. patients are female. 2 . ** 80% - 90% of F.M. patients are female.
3. ** M.E. usually occurs in the 30 - 45 age bracket. 3. ** F.M. usually occurs in the 40 - 60 age bracket.
5. ** M.E. tends to be a 5-10 year illness, with partial recovery. 5. ** F.M. tends to be a permanent condition, with a reduction of symptoms following treatment.
6. ** M.E. does not show many arthritic symptoms 6. ** Fibromyalgia has many arthritic-like symptoms
7. ** Exercise creates more severe symptoms. #940808-5 "Exercise as well as other physical and mental activities can exacerbate cognitive and other symptoms associated with M.E." 7. **A small amount of aerobic exercise does help #940808-5
8. **In general, patients have some bowel and intestinal problems 8. ** Sufferers have much more bowel and intestinal problems
9. ** Patients with M.E. only, do not have the 11 of 18 tender points for diagnosing. 9. ** Patients with "Fibroymalgia only", have tender points for pain, which are used in diagnosing
10. ** M.E. is thought to be an infectious viral disease. (CDC Dublin Conference #940806-35) There have been many recorded epidemics over decades 10. ** F.M. is largely recognized as a condition, surfacing because of an event. I have heard of no epidemic or outbreak of F.M.
11. ** M.E. has severe fatigue, fever, swollen glands, blood abnormalities, and evidence of infection. #950103-13 11. ** F.M. has few of these.
12. ** M.E. symptoms tend to fluctuate on an hourly, daily, monthly and yearly basis 12. ** F.M. symptoms tend to be more steady over monthly and yearly basis.
13. ** M.E. has more remissions and re-occurances 13. ** F.M. rarely has remissions.
14. ** The major symptoms of M.E. are cognitive and fatigue problems. 14. ** The major symptoms of F.M. are pain and muscle weakness
I5. ** Patients take years to recover and some are not able to return to work. 15. ** Most patients tend to recover enough to return to work (see following charts)
16. ** M.E. patients are extremely sensitive to prescription drugs. 16. ** F.M. patients are sensitive to prescription drugs.
17. ** Viral illness appears as the cause more often. 17. ** Viral illness does not appear that often.
18. ** Immune dysfunction is more common. 18. ** Immune dysfunction is not very common (Dr. Mohammed Unis)
19. ** The Centre for Disease Control has specific criteria for M.E. 19. ** The Centre for Disease Control has specific criteria for F.M.


3)** C.F., F.M., and C.F.S. - the
differences.  Chronic Fatigue, Fibromyalgia
and Chronic Fatigue Syndrome are not the same
illness.  The following diagram can be used to
illustrate this: 

     a)** The diagram shows the percentage of
     the general population that is affected by all
     three.

     b)** The relationship between the three and
     how they interact between each other.

     c)** Chronic Fatigue is a symptom found
     in most debilitating illnesses such as
     cancer, Lupus, Lyme Disease, AIDS, etc. 
     Dr. Charles Lapp of the Cheney Clinic, 
     and others, have expressed this many
     times.  This symptom, which consists of
     only being very tired, is also a common
     symptom with both M.E. and F.M.  Dr.
     Anthony Komaroff, one of the key
     designers of the 1988 and 1994 CDC
     definition for Chronic Fatigue Syndrome,
     believes there are two separate states -  one
     chronic fatigue, the other one chronic
     fatigue syndrome.  The chronic fatigue
     comes with cancer or thyroid problems and
     several other illnesses. The new 1994 CDC
     criteria also makes this distinction.



4)** Charts of severity and duration
of symptoms  for M.E. or F.M. patients.
#940805-4. {PO}{My best estimate from materials
I have read and from speaking with people in
support groups, is as follows; this information is
for the general population - some patients will not
fall within these percentages.  M.E. only patients
do get some relief to a varying degree after several
years.  These figures account for all the people
who have ever contracted M.E. or F.M., and how
they are doing at this point in time.  Many
calculations do not include those who have not yet
been diagnosed, have been improperly diagnosed,
or people who are in partial or full remission. 
Similar to arthritis, some people are still able to
work while suffering with symptoms, while for
others the symptoms are too severe for them to be
able to work.}

EFFECTS AND RECOVERY

M. E.

F. M.

All those who have been ill (1) At onset of illness All those who have been ill At onset of condition (3)
Percentage of population with .003 (2)

3% - 5%

For a city of 100,000 # of affected.

300

3,000 - 5,000

Able to work full time

40%

7%

94%

80%

Able to work part time

30%

18%

4%

20%

Totally Disabled

30%

75%

2%

10%



NOTE: (1) M.E. affects 3 per 1,000.  As a comparison M.S. affects 2 per 1,000, and Cystic
Fibrosis  affects 1 in 2,500 people, equal to .0004% of the population. 
      (2) As M.E. sometimes has epidemics, (similar to a bad flu year) these numbers will
fluctuate.  
      (3) FM may have a gradual onset over many years so these figures are more 
dificult to estimate.



% OF PEOPLE ABLE TO GO BACK TO WORK FULL OR PART TIME

# of years with illness (1)

    2

4

6

8

More than 10

M.E.

35%

20%

10%

5%

30% never return #93057-10

F.M. (2)

94%

2%

1%

1%

2% Never return



NOTE: (1) This does not mean that either M.E or F.M. people were cured, just that the
disability was     reduced enough to return to work.
      (2)  These percentages are based on 3-5% of the entire healthy population getting F.M.  A
large    percentage of those are never disabled enough to have to stop work.

5)** Recovery. There have been nolong-term studies done of people with M.E.  The
figures used by many are from "how do you feel
today" questionnaires.  My experience from the
support groups is that many M.E. patients say they
are cured or they are taking something that has
cured them, only to hear six months later that they
had a relapse.  {PO}{I believe the recovery rates
for M.E. patients will show a longer duration of
debilitating illness and a better reflection of the
working disabled (like arthritis).}

     a)** 60% - 70% of patients do not seem to
     fully recover from M.E., but recover to
     80% to 90% of what they were previous to
     the illness taking effect.  Even after a
     remission the illness may come back. 
     (#92002 Video1@ 0:04).  Children and
     teenagers seem to recover 3 - 4 times faster
     than the average adult.  {PO}{Males do
     seem to recover slightly faster than
     females, which may be why there are more
     females sick at any given time.}

     b)** There are an estimated 1 to 5 million
     people in North America and Europe with
     M.E., with 150,000 in Canada (#90001-1).

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M.E. & FM Manual --Main Page
Updated 97/03