1)** Following are two charts comparing M.E. with depression, and M.E. & F.M. Following those two charts, is a third chart showing the severity and duration of M.E. & F.M. These charts are the best summarization of all materials I could find. "M.E. only" and "F.M. only" are compared here, as 75% of M.E. patients have F.M. as well; however only 5% of F.M. patients have M.E. The distinctions between M.E. & F.M. may sometimes be "fuzzy". These comparisons are in general terms; M.E. or F.M. can start from young children up to those 80 years of age. (#92055 Video2 @6:41); (#92056 Video3@3:10). M.E. & F.M. are not the same as depression. It is very important that a diagnosis be done by a doctor who is familiar with M.E. or F.M., as there are many people who do not have these illnesses, but have been diagnosed with it. This does great harm to those that actually have it. An extensive investigation must be done to ensure that you do not have another major illness. 2)** Written psychological tests show the differences between M.E. and depression quite clearly - eg "Do you feel like doing things during the day?" For an M.E. patient, the answer would be "Yes, I feel like doing things even though I am not physically able to and/or I don't pace myself and then do too much"; for a depressed person, the answer would be "No, I don't feel like doing anything during the day, even though I may be physically capable of doing something."
Comparison of M.E. and Depression
M.E. ONLY |
DEPRESSION ONLY (#92033-19) (#93001) |
1. ** SPECT scans done after exercise show an a decrease in brain activity (#91022 Video 1@1:50) #94024-12; #940805-17; #94009-1. Dr . Ishmel Mena & Dr. Jay Goldstein, Dr. Anthony Komaroff #950301-5 | 1. ** SPECT scans done after exercise show an increase in brain activity, as is expected of the normal functioning brain |
2. Exercise makes the patient feel worse with an increase of symptoms often for days, sometimes starting 24-48 hours after. | 2. Exercise seems to help the depressed person with sleep and other symptoms. (#940805-21 ) |
3. M.E. patients are generally well-adjusted, but are tired of being sick and have high motivation. | 3. Depressed patients commonly have problems with life, family, or society and have low motivation (#940805-21 ) |
4. ** Antidepressants in low, medium or high dosages seem to do very little to alleviate the M.E. symptoms, and most patients have intolerance to many drugs. These are usually effective at a very low dose, which is not effective on depression but works on muscle pain, sleep and headaches. | 4. ** Anti-depressants seem to help most depressed patients. Lower dosages have little effect. |
5. M.E. patients have alcohol intolerance. | 5. Depressed patients have no alcohol intolerance, with some patients suffering from alcoholism. |
6. Rivotril in low dosages (1 mg) helps with night sweats and sleeping problems. | 6. Rivotril in low dosages has little or no effect. |
7. M.E. has many specific symptoms | 7. Depression may cause a few, but not all of these specific symptoms |
8. Strong sleeping pills do little to keep M.E. patients asleep through the night, with patients waking up unrefreshed. | 8. Strong sleeping pills seem to help with sleeping problems |
9. **Cortisol levels in urine samples are abnormally low . #941101-13 (#92055 Video2@6:42) | 9. ** Cortisol levels in urine samples are abnormally high . #941101-13 |
10. ** Headaches are far more debilitating, repetitive, and almost unstoppable with medication. | 10. ** Headaches are as in the general population (#940806-8) |
11. ** Patients have been tested for brain wave activity using EEG's (#940805-18) during awake and asleep periods. While awake, sleep waves are being produced, and while asleep, awake waves are being produced. Dr. Cheney, Dr. Lapp (#92055 Video2@7:14) | 11. ** Sleep waves are normal . |
12. ** Short-term memory proved to be significantly reduced in a study of 150 M.E. patients. Memorization cues proved worthless. #94009-6; #940805-14 & 21. Memorization significantly impaired by brief interruption. | 12. ** Study compared depressed and normal people. Both categories had no effect in short-term memory loss . Memorization cues helped. (#940805-14) Memorization not impaired by brief interruption. |
13. ** Cognitive or brain functions are impaired. | 13. ** Little cognitive problems |
14. **M.E. patients tend to over-estimate their abilities on cognitive psychological tests. | 14. ** Depressed patients tend to under-estimate their abilities on cognitive tests. (#940805-21) |
15. ** M.E. has definite immune abnormalities, proven in many studies, and by the National Institute for Allergies and Infectious Diseases (NIAID) #93016-2; #93014-5 . (#93052 Video4@0:30) | 15. ** Depressed patients have few immune abnormalities. |
16. ** Symptoms not common to depression: mild fever, sore throat, painful or swollen lymph nodes, unexplained generalized muscle weakness, muscle pain, sudden onset, neurological disturbances and many otbers . | 16. **Depressed patients do not have the large number of specific symptoms that M.E. people do. |
17. ** High motivation | 17. ** Low motivation |
M.E. only #92028-53 |
F.M. Only #90046 |
1. 75% of M.E. patients have fibromyalgia symptoms | l. ** A person may have Fibromyalgia but not have M.E.; about 5% of F.M. patients have M.E. as well. |
2 . ** 60% - 70% of M.E. patients are female. | 2 . ** 80% - 90% of F.M. patients are female. |
3. ** M.E. usually occurs in the 30 - 45 age bracket. | 3. ** F.M. usually occurs in the 40 - 60 age bracket. |
5. ** M.E. tends to be a 5-10 year illness, with partial recovery. | 5. ** F.M. tends to be a permanent condition, with a reduction of symptoms following treatment. |
6. ** M.E. does not show many arthritic symptoms | 6. ** Fibromyalgia has many arthritic-like symptoms |
7. ** Exercise creates more severe symptoms. #940808-5 "Exercise as well as other physical and mental activities can exacerbate cognitive and other symptoms associated with M.E." | 7. **A small amount of aerobic exercise does help #940808-5 |
8. **In general, patients have some bowel and intestinal problems | 8. ** Sufferers have much more bowel and intestinal problems |
9. ** Patients with M.E. only, do not have the 11 of 18 tender points for diagnosing. | 9. ** Patients with "Fibroymalgia only", have tender points for pain, which are used in diagnosing |
10. ** M.E. is thought to be an infectious viral disease. (CDC Dublin Conference #940806-35) There have been many recorded epidemics over decades | 10. ** F.M. is largely recognized as a condition, surfacing because of an event. I have heard of no epidemic or outbreak of F.M. |
11. ** M.E. has severe fatigue, fever, swollen glands, blood abnormalities, and evidence of infection. #950103-13 | 11. ** F.M. has few of these. |
12. ** M.E. symptoms tend to fluctuate on an hourly, daily, monthly and yearly basis | 12. ** F.M. symptoms tend to be more steady over monthly and yearly basis. |
13. ** M.E. has more remissions and re-occurances | 13. ** F.M. rarely has remissions. |
14. ** The major symptoms of M.E. are cognitive and fatigue problems. | 14. ** The major symptoms of F.M. are pain and muscle weakness |
I5. ** Patients take years to recover and some are not able to return to work. | 15. ** Most patients tend to recover enough to return to work (see following charts) |
16. ** M.E. patients are extremely sensitive to prescription drugs. | 16. ** F.M. patients are sensitive to prescription drugs. |
17. ** Viral illness appears as the cause more often. | 17. ** Viral illness does not appear that often. |
18. ** Immune dysfunction is more common. | 18. ** Immune dysfunction is not very common (Dr. Mohammed Unis) |
19. ** The Centre for Disease Control has specific criteria for M.E. | 19. ** The Centre for Disease Control has specific criteria for F.M. |
3)** C.F., F.M., and C.F.S. - the differences. Chronic Fatigue, Fibromyalgia and Chronic Fatigue Syndrome are not the same illness. The following diagram can be used to illustrate this: a)** The diagram shows the percentage of the general population that is affected by all three. b)** The relationship between the three and how they interact between each other. c)** Chronic Fatigue is a symptom found in most debilitating illnesses such as cancer, Lupus, Lyme Disease, AIDS, etc. Dr. Charles Lapp of the Cheney Clinic, and others, have expressed this many times. This symptom, which consists of only being very tired, is also a common symptom with both M.E. and F.M. Dr. Anthony Komaroff, one of the key designers of the 1988 and 1994 CDC definition for Chronic Fatigue Syndrome, believes there are two separate states - one chronic fatigue, the other one chronic fatigue syndrome. The chronic fatigue comes with cancer or thyroid problems and several other illnesses. The new 1994 CDC criteria also makes this distinction.
4)** Charts of severity and duration of symptoms for M.E. or F.M. patients. #940805-4. {PO}{My best estimate from materials I have read and from speaking with people in support groups, is as follows; this information is for the general population - some patients will not fall within these percentages. M.E. only patients do get some relief to a varying degree after several years. These figures account for all the people who have ever contracted M.E. or F.M., and how they are doing at this point in time. Many calculations do not include those who have not yet been diagnosed, have been improperly diagnosed, or people who are in partial or full remission. Similar to arthritis, some people are still able to work while suffering with symptoms, while for others the symptoms are too severe for them to be able to work.}
M. E. |
F. M. |
|||||
All those who have been ill (1) | At onset of illness | All those who have been ill | At onset of condition (3) | |||
Percentage of population with | .003 (2) |
3% - 5% |
||||
For a city of 100,000 # of affected. |
300 |
3,000 - 5,000 |
||||
Able to work full time |
40% |
7% |
94% |
80% |
||
Able to work part time |
30% |
18% |
4% |
20% |
||
Totally Disabled |
30% |
75% |
2% |
10% |
NOTE: (1) M.E. affects 3 per 1,000. As a comparison M.S. affects 2 per 1,000, and Cystic Fibrosis affects 1 in 2,500 people, equal to .0004% of the population. (2) As M.E. sometimes has epidemics, (similar to a bad flu year) these numbers will fluctuate. (3) FM may have a gradual onset over many years so these figures are more dificult to estimate.
# of years with illness (1) |
2 |
4 |
6 |
8 |
More than 10 |
M.E. |
35% |
20% |
10% |
5% |
30% never return #93057-10 |
F.M. (2) |
94% |
2% |
1% |
1% |
2% Never return |
NOTE: (1) This does not mean that either M.E or F.M. people were cured, just that the disability was reduced enough to return to work. (2) These percentages are based on 3-5% of the entire healthy population getting F.M. A large percentage of those are never disabled enough to have to stop work. 5)** Recovery. There have been nolong-term studies done of people with M.E. The figures used by many are from "how do you feel today" questionnaires. My experience from the support groups is that many M.E. patients say they are cured or they are taking something that has cured them, only to hear six months later that they had a relapse. {PO}{I believe the recovery rates for M.E. patients will show a longer duration of debilitating illness and a better reflection of the working disabled (like arthritis).} a)** 60% - 70% of patients do not seem to fully recover from M.E., but recover to 80% to 90% of what they were previous to the illness taking effect. Even after a remission the illness may come back. (#92002 Video1@ 0:04). Children and teenagers seem to recover 3 - 4 times faster than the average adult. {PO}{Males do seem to recover slightly faster than females, which may be why there are more females sick at any given time.} b)** There are an estimated 1 to 5 million people in North America and Europe with M.E., with 150,000 in Canada (#90001-1).-------------------