MULTIPLE SCLEROSIS

1. ONSET OF THIS DISEASE IS CHARACTERIZED IN EARLY ADULT LIFE. THERE OCCURS PROFUSE NEUROLOGICAL DISTURBANCES WITH REGULAR PERIODS OF FLUCTUATIONS, EXACERBATION AND IMPROVEMENT. THE CAUSE IS UNKNOWN BUT VARIOUS THEORIES ABOUT DEGENERATIVE, TOXIC AND DEFICIENCY STATES HAVE BEEN FORWARDED.

2. IRREGULAR GRAY PATCHES OF DEGENERATION/DEMYLINATION, OF VARYING SIZES, FROM MILLIMETERS TO CENTIMETERS OCCUR IN SPINAL CORD, BRAIN STEM OR BRAIN ITSELF. THESE PATCHES HAVE PREDILECTION FOR WHITE MATTER.

3. SYMPTOMS OF THE DISEASE ARE

	SUDDEN MOTOR AND SENSORY DISTURBANCES,
	DIFFUSED NEUROLOGICAL SIGNS,
	CLUMSINESS,
	IMPAIRED SENSATIONS,
	EXTREME WEAKNESS,
	STAGGERING GAIT,
	LOWER LIMBS WHICH ARE USUALLY AFFECTED, FEEL HEAVY AND WOODEN

4. THE MAIN CAUSE IS DESTRUCTION OF MYLIN, A LIPID SUBSTANCE, WHICH PROTECTS THE NERVE FIBER AND IS ESSENTIAL FOR PROPER CONDUCTION OF IMPULSES.

THIS DIAGRAM SHOWS THE SECTION OF A NERVE. INNER PORTION SHOWN IN [RED COLOR] IS AXON, THE NERVE FIBER. IT IS COVERED BY A VIOLET COLORED [COLOR AS SHOWN IN THIS PICTURE], CALLED AS MYELIN SHEATH. ITS CONSTITUENTS ARE LIPIDS.

5. The initial attack AND SUBSEQUENT RELAPSES OCCUR AFTER ACUTE INFECTIONS , TRAUMA, VACCINATIONS AND SOME TYPE OF SOMATIC STRESS.

6. INITIAL SIGNS AND SYMPTOMS ARE

	NUMBNESS OF EXTREMITIES, ATAXIA, VISUAL DISTURBANCES
	SPASTIC PARALYSIS
	DEEP TENDON REFLEXES ARE INCREASED
	BILATERAL EXTENSOR PLANTER RESPONSE
	NYSTAGMUS
	WEAKNESS
	THE WIDESPREAD NEUROLOGICAL LESIONS CAN NOT BE EXPLAINED BY ANYONE ANATOMIC BASIS.

7. THESE SIGNS AND SYMPTOMS ARE SUBJECT TO ACUTE EXACERBATION AND REMISSIONS. THESE TWO CHARACTERISTICS MAKE EARLY DIAGNOSIS VERY DIFFICULT

8. LABORATORY FINDINGS ARE—

GAMMA GLOBULIN ARE INCREASED IN CEREBROSPINAL FLUID, OLIGOCLONAL BANDS OF IgC MAY SOME TIMES BE DETECTED IN ELECTROPHORESIS OF CEREBROSPINAL FLUID VISUAL EVOKED POTENTIAL TO BOTH FLASH AND PATTERN ARE ABNORMAL, WITHOUT KNOWN SIGNS OR HISTORY OF VISUAL IMPAIRMENT. MRI SCAN OF HEAD OR /AND SPINAL CORD MAY SHOW LESIONS.

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