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This activity is almost certainly related to muscle growth, and it requires high doses. ordering steroids online, steroids medical use, big women bodybuilding, male bodybuilding gallery, blood transfusion steroids, quality vet steroids, female muscle gallery, big muscle, steroids law, anabolic cycles Anabolic steroid info. Testosterone is observed to increase the efficiency of mRNA translation of cellular proteins, and this may be mediated by a mechanism independent of the AR. Nerve tissue has been observed to respond almost instantly to androgen. This cannot be a result of the AR mediated process I have described here, because that process takes much more time. ordering steroids online, steroids medical use, big women bodybuilding, male bodybuilding gallery, blood transfusion steroids, quality vet steroids, female muscle gallery, big muscle, steroids law, anabolic cycles Big muscle. Generally speaking, the hypothesis that a drug acts by only one mode of action can be tested by examining the dose/response curve. If an effect is dependent only upon the activity of a receptor, then the log response should follow a sigmoidal function (an S shaped curve). The graph would be nearly flat both at low and high doses, and approximately linear at moderate doses. ordering steroids online, steroids medical use, big women bodybuilding, male bodybuilding gallery, blood transfusion steroids, quality vet steroids, female muscle gallery, big muscle, steroids law, anabolic cycles Mexican steroid. At moderate doses the linear function is indeed seen. The problem is, for the range of approximately 100 to 1000 mg/week, the graph remains linear regardless of dose! By the way, this does not mean that twice the dose gives twice the effect. Rather, about four times the dose is required to give twice the effect. This response is not consistent with a simple receptor-only model; such a model is not supported by the dose/response curve. But this type of response is to be expected if there are other variables besides receptor binding. This can be explained if one or more of the mechanisms is saturated at lower levels of drug, and one or more other mechanisms do not become saturated until much higher levels of drug are used. High doses of AAS might improve the efficiency of action of ARsNot only the number of ARs is important, but also their efficiency of operation. The entire process, as was partially described above, involves many proteins, some of which may be limiting. Increases in the amounts of these proteins might increase activity dramatically. For example, ARA70 is a protein which can improve the activity of the AR by ten times. I am not aware of any study determining how ARA70 may be regulated by high doses of AAS. I cite this as an example of the type of pharmacology that may be going on, and also, incidentally, as a potential target. If you happen to see where some other drug has been seen to increase ARA70, that might be very interesting!Other proteins which can affect efficiency include RAF, which enhances the binding of the AR to DNA by about 25-fold; GRIP1, and cJun. None of these, unfortunately, could themselves be taken as drugs. But you can see that there are many ways by which AR activity could change besides any "upregulation" or "downregulation" of receptors. Authors who make such claims as the be- all and end-all of their steroid theories essentially do not know what they are talking about. Without specific evidence - without actual measurement of AR levels - it is always unjustified to claim that "androgen receptor downregulation must have occurred," especially on the basis of anecdotal evidence. Actual measurements are always lacking from such claims. Nor is it justified to assume that increasing the occupancy of ARs is the only way to increase the effect of androgens, as we have seen. It is justified, on the basis of real world results, to say that high dose AAS are more effective than low dose AAS, and certainly more effective than natural levels of AAS. This is true even if use is sustained over time.
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