Tetanus is an acute, often fatal infectious disease caused by an exotoxin produced
by Clostridium tetani, a spore-forming bacteria. Classic symptoms include generalized
rigidity and convulsive spasms of the skeletal muscles. The muscle stiffness commonly
involves the jaw and neck, and then becomes widespread. C. tetani usually enters
the body through a puncture wound. The spores germinate in the anaerobic conditions,
and toxins, including tetanospasmin, are produced. The toxins travel through the
body via the blood and lymphatics, and act at several central nervous system sites
including peripheral motor end plates, spinal cord, brain, and sympathetic nervous
system. Tetanus toxin interferes with neurotransmitter release, blocking inhibitor
impulses and resulting in unopposed muscle contraction and spasm. Seizures can
occur as well.1 Diagnosing tetanus in modern medicine is particularly challenging
because it mimics other infectious disease processes and is considered preventable
in today's world.
Case History
cialis - check it
tramadol - check it
viagra - check it
levitra - check it
phentermine - check it
xenical - check it
prozac - check it
zoloft - check it
fioricet - check it