Mak was born in Hong Kong and awarded his bachelor degree with first hounor from the department of biochemistry, The University of Hong Kong. He received his Ph.D. degree from the department of paediatrics and adolescent medicine, The University of Hong Kong in 2002. After a brief training in the department of medicine, he joined the National Human Genome Research Institute (NHGRI) at National Institute of Health (NIH) in United States. His research interest is mainly focus on developmental biology. During his Ph. D. studies, he investigated the role of Epidermal growth factor (EGF) in hair and skin development by making use of genetic engineered animal model-transgenic mice. While Mak's current research continues towards a better understanding in early developmental processes in vertebrates, he is now studying vetebrate limb development and skeletal morphogenesis by taking interest on deciphering the role of hedgehog signaling and Wnt/beta-catenin signaling in regulation of endochondral bone formation. |