Muscle fitness

But it does answer the question as to whether the drug will or will not bind to the desired receptor. muscle fitness Truth-about-steroids. In this study, the ability of these compounds to bind to androgen receptors, or their binding affinity, was compared to that of 3H-MIB which is known to have a very high affinity for the androgen receptor. The efficacy, or ability of the compound to stimulate maximum transcriptional activity in intact cells, was compared to that of DHT which is thought to be the dominant compound by which androgenic activity is stimulated in the body. The potency, or the lowest concentration of ligand able to induce maximal transcriptional activity in intact cells, was also compared to that of DHT. muscle fitness Blood type diets. This study is the first to discover compounds that do not share the steroidal structure that are able to bind with the androgen receptor as an agonist for transcriptional activity. Remember that transcription is the first step in protein synthesis. It is sort of ironic that these compounds were created using the structure of known anti-androgens. muscle fitness Muscle-stretching. One particular compound named R-1 had very similar androgenic activity to that of DHT. Considering that testosterone has a binding affinity (to androgen receptors) that is only ~10- 50% that of DHT, where as several of these new non-steroidal compounds had affinities that were nearly identical to DHT, shows that these new compounds have tremendous potential in bodybuilding. Of course, data on dissociation rates were not provided. It is believed that the different dissociation rates of testosterone and DHT are responsible for the greater potency of DHT. So why create drugs that act like steroids but aren't steroids? Well, simply put, side effects and control. Many of the unwanted side effects of testosterone and its derivatives are a result of its structure. The ultimate goal in creating a ligand for the androgen receptor for myotropic activity would be to create a drug that has high binding affinity (i. e. similar if not greater than DHT) as well as a slow dissociation rate, and a low rate of hepatic clearance from the system. The inability of these drugs to be converted into estrogen is also a great advantage of their non-steroidal structure.

Muscle fitness



Weight loss books || Bodybuilding video clips || Muscle fitness || Articles-on-steroids