12. Spindle Epithelial Tumor with Thymus-like Differentiation (SETTLE) Claude Roofian SETTLE is a rare spindle cell tumor of the thyroid gland that has not been completely characterized. This tumor is of epithelial origin, which may originate from the thymus or third branchial pouch. Clinical Features: SETTLE typically occurs in adolescents and young adults. It usually presents as a mass in the neck localized to the thyroid. Treatment has predominantly been surgical, although chemotherapy and radiation have also been used. Surgery may be a cure, but late metastasis has been observed. http://www.mol.net/md/croofian/c-roofian.htm undefined undefined More... undefined [Close] undefined [Close] undefined