- Accession Number
- XX810-0013
- Document Delivery
- The Genuine Article
Number: XX810
- Authors
- Karadag
E. Saraydin
D. Guven
O.
- Title
- INTERACTION OF NICOTINE AND ITS PHARMACEUTICAL DERIVATIVES WITH
ACRYLAMIDE/ITACONIC ACID HYDROGELS
- Source
- Journal of Applied Polymer Science. 66(4):733-739, 1997 Oct 24.
- ISSN
- 0021-899
- Author Keywords
- Hydrogel. Poly(acrylamide/itaconic
acid). Nicotine. Sorption. Interaction.
- KeyWords Plus
- Bovine serum-albumin. Cationic dyes. Aqueous-solutions. Adsorption.
Biocompatibility. Behaviors.
- Abstract
- Acrylamide/itaconic acid hydrogels (AAm/IA) containing different amounts
of itaconic acid prepared by irradiating with gamma radiation were used in
experiments on swelling, diffusion, and interactions of the pharmaceuticals
nicotine, nicotinic acid, nicotinamide, and nikethamide. AAm/IA hydrogel
containing 60 mg itaconic acid and irradiated at 4.65 kGy has been used for
swelling and diffusion studies in water and aqueous solutions of the
pharmaceuticals. For this hydrogel, swelling studies indicated that swelling
increased with the following order: water > nicotine > nikethamide
> nicotinamide > nicotinic acid. Diffusions of water and the
pharmaceuticals within hydrogels were found to be non-Fickian in character.
The uptake of the pharmaceuticals to AAm/IA hydrogels was studied by batch
adsorption technique at 25 degrees C. In the experiments of the adsorption,
C-type adsorption in Giles's classification system was found. Some binding
and thermodynamic parameters for AAm/IA hydrogel-pharmaceutical systems were
calculated by using the Klotz method. The values of adsorption heat, free
energy, and entropy of this system were found as negative values. (C) 1997
John Wiley & Sons, Inc. [References: 29]
- Language
- English
- Publication Type
- Article
- CC Categories
- Organic chemistry/polymer science. Materials science and engineering.
- Subset
- Current Contents/Physical, Chemical & Earth Sciences
Current Contents/Engineering, Technology & Applied Sciences
- Institution
- Reprint available from
- Karadag
- CUMHURIYET UNIV DEPT CHEM TR-58140 SIVAS
TURKEY
- HACETTEPE UNIV DEPT CHEM TR-06532 BEYTEPE
ANKARA TURKEY