National Library of Medicine: IGM Full Record Screen
TITLE:
Blood dehydroepiandrosterone sulphate (DHEAS) levels
in pemphigoid/pemphigus and psoriasis.
AUTHOR:
de la Torre B; Fransson J; Scheynius A
AUTHOR
AFFILIATION:
Department of Clinical Neuroscience, Karolinska
Hospital, Stockholm, Sweden.
SOURCE:
Clin Exp Rheumatol 1995 May-Jun;13(3):345-8
NLM CIT. ID:
96044538
ABSTRACT:
Serum dehydroepiandrosterone sulphate (DHEAS) levels
and diagnostic autoantibody titers were measured in
patients with pemphigoid/pemphigus [n = 46/4; 21 men
and 29 women, 42 to 93 years of age (mean 79)].
Twenty-four patients were either on peroral
Prednisolone (n = 11), or topical treatment with
betamethasone (n = 13), and the other 26 were either
receiving non-steroidal drugs or were untreated. Their
DHEAS levels were compared to those of 20 patients
with psoriasis, and to 23 patients with secondary
osteoarthritis (OA). Assessing the patients by group,
the mean DHEAS level was markedly lower in the
pemphigoid/pemphigus than in the psoriasis and OA
patients (geometric mean 600 vs. 2130 and 2100 nmol/l,
respectively; p < 0.001). This difference was
independent of steroid treatment. No correlation was
found between the DHEAS levels and antibody titers.
The low levels found in pemphigoid/pemphigus are
concordant with those reported for systemic lupus
erythematosus, rheumatoid arthritis and polymyalgia
rheumatica/giant cell arteritis. DHEAS deficiency is a
permanent feature in these autoimmune diseases, and
may contribute to their etiology and/or
pathophysiology.
MAIN MESH
SUBJECTS:
Pemphigoid, Bullous/*BLOOD/DIAGNOSIS/DRUG THERAPY
Pemphigus/*BLOOD/DIAGNOSIS/DRUG THERAPY
Prasterone/*ANALOGS & DERIVATIVES/BLOOD
Psoriasis/*BLOOD/DIAGNOSIS/DRUG THERAPY
ADDITIONAL
MESH SUBJECTS:
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal/THERAPEUTIC
USE
Anti-Inflammatory Agents, Steroidal/THERAPEUTIC USE
Autoantibodies/BLOOD
Betamethasone/THERAPEUTIC USE
Comparative Study
Female
Human
Male
Middle Age
Osteoarthritis/BLOOD
Prednisolone/THERAPEUTIC USE
PUBLICATION
TYPES:
JOURNAL ARTICLE
LANGUAGE:
Eng
REGISTRY
NUMBERS:
0 (Anti-Inflammatory Agents, Non-Steroidal)
0 (Anti-Inflammatory Agents, Steroidal)
0 (Autoantibodies)
378-44-9 (Betamethasone)
50-24-8 (Prednisolone)
53-43-0 (Prasterone)
651-48-9 (Dehydroepiandrosterone Sulfate)
(
geocities.com/hotsprings)