- Wanda and Pietro Frank/Maximoff/Lehnsherr
- Jean Paul and Jeanne-Marie Baubier
- John and Jason, Darkhawk's brothers
- The Blood Brothers
- Andrea and Andreas Strucker
- The Bi-Beasts
- (*) Scarlet and Vision sons (they never existed or...)
- Tobias and Malachi (Kang e Mantis')
- The Lobo Brothers
- Gemini (of the Zodiac II)
- Brother(s) Voo-Doo
- (*) The Grimm Brothers (I, Jake and William Dolly, but now?)
- Midnight's Fire and Silohuette
- Joey and Gailyn (Sara Grey's children, Jean's nieces)
- Ernesto and Luigi Gambonno of the Circus of Crime
- Betsy and Brian Braddock
- Dark Star and Vanguard
- Xi'an and Trahn Coy Mahn and...
- Leong and Nga Coy Mahn
- AC and DC (of the Warpies)
- Oto and Efialte (the sea twins)
- Desmond and Phoebe Marrs
- Rory and Pandora Destine
- Alysande and Alistaire Stuart
- Pinky & Hubert Fusser (Fusion I)
- Shell and Shot (of Shadowforce Alpha)
- Monet's brothers (of Generation-X)
- Wildblood/Occulus
- The Seeker I and II (of the Inhumans)
- The Kleinstock Brothers (of the Acolytes)
- Kevin and Mick (Volstagg's sons-in-law)
- Double Trouble (of Weapon Prime)
- Ox I and II
- Donna and Bess Bliss (Skin II and Bones
II)
- Rosa and Marie Esteves (Skin I and Bones I)
- Assault and Battery
- Blacklight and Whitenoise (Deathbird's sons)
- The Naiads of Stepford (five little mutants of the Xavier and Frost's
X-school)
- Stacey and Tracey Hoffner (kissed by Mammoth II)
- Timberius and Naanis (Inhumans)
- Quentin and Lenore (Red Lucy's sons)
- Killed by Lizard with their parents in the Everglades
- Alexandre (the first Zombie) and Laurent (the first Brother Voodoo)
- Larry and Lenny Cebulsky (respectively, killed by and shot Kingpin)
- The Murphy brothers (psichopathic killers, one was hired by Kingpin and
killed Lenny Cebulsky)
- Roust and Joust (of the Abominations)
- Clare Dodgson and Ann Stafford (both possessed by the Enigma Force)
- Twin Enforcers of the Dermafree (killed by Mystique)
- Ned and Ted (met by Ant-Man on big Christmas)
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