U.S 72 connects Chattanooga to Memphis, TN, swinging through Alabama and Mississippi along the way.
U.S. 73 links Dawson, NE to Victory Junction, KS. Until 1965, the highway extended to South Sioux City, NE and Omaha, NE.
U.S. 74 goes from Wrightsville Beach, NC to Cleveland, TN. A freeway portion of the highway between Rockingham and Whiteville, NC is slated to become Interstate 74, the first time that an Interstate and US route with the same number are signed on the same road.
U.S. 75 runs from Kittson County, MN to Dallas, TX. It also extended to Houston and Galveston, TX, before being replaced by Interstate 45.
U.S. 76 connects Wrightsville Beach, NC to Chattanooga, TN.
U.S. 77 runs from Sioux City, IA to Brownsville, TX. It is unsigned in and around Dallas, TX.
U.S. 78 links Charleston, SC to Memphis, TN. A freeway portion between Birmingham, AL and Memphis is slated to be upgraded to Interstate 22.
U.S. 79 goes from Russellville, KY to Round Rock, TX.
U.S. 80 runs from Tybee Island, GA to Dallas, TX. Originally, it also extended to San Diego, CA.
