You think you're so great? You think you've been given a gift? You think you're got a working relationship with the humans? Well look at me. Yea, look at what the great gift means to ME. Now look at yourself. I'd give you a mirror, but I'm fresh out...
The main reason people play Vampire, I think, is that they want to be immortal, and that they want to be better than the average human could ever be. As vampires they are things to be feared, yet secretly desired, sexy but dangerous killers who will forever be beautiful, forever free to improve themselves and enjoy their lives. That's why I think the Nosferatu are so popular: if you ever want to shove the whole game in the face of the other players, try properly roleplaying a Nosferatu. Immediately you'll be totally different from any other member of the group. You'll be morbid, pessimistic, and angry. Your hideous looks will shock Toreador, piss of Brujah, and make just about everyone else extremely uncomfortable because they see themselves in you: but for the grace of whomever, they'd be you.
Is living in sewers cool? Heck yea! While the other vampires are living in their versions of human residences, you're skulking around in your own little underground kingdom. You've got a safe place to go where you can be together with your kind and exchange information and feel sorry for yourselves. While greedy rivals are destroying Toreador bachelor pads and Ventrue penthouses, nobody dares set foot in your sewers, because of what they know is down there... and even more so because of what they don't know is down there.
Nosferatu have a way-cool job in the Vampire world: they're the information brokers, and are perfect for the job. If you want to get the dirty little bits of info on what's going on, you're gonna want to go to the dirtiest vampires. If you want to know the ugly truth, go to the ugly Nosferatu. Plus, it gives the Nosferatu another fear point... forget being repulsive and living in dangerous sewers, you never know what they know about you and will be glad to spread around if you screw with them.
Okay, another fear point: you can totally kick the trash out of whatever pisses you off. Potence is nice here, but when messing with Brujah or the other bruisers in the World of Darkness (Garou come to mind, and of course other vampire clans with Potence, Celerity and/or Fortitude) you're gonna want to be able to kick some ass without getting your (grody) ass kicked. You're going to want amazing natural stealth combined with Obfuscate. They can't fight what they can't see, and even more than that, they can't get away if they don't know you're there at all. Animalism is nice for gathering information and getting some animal peons to guard your pimp pad (er... I mean swampy pit of effluence). It's also cool for roleplaying purposes... talking to the stray dogs and bloated rats of a city will really define your Nosferatu.
One last thing, and I've mentioned this before. (You see this coming, so say it with me:) Nosferatu! Say it out loud! Whisper it menacingly: Nos... fer... a... tu......
Now get out there and make a sewer vampire! Woohoo!