Positions held | |
since 8/07 |
Global Head of Statistics for Early Clinical Development at F. Hoffmann La-Roche AG in Basel, Switzerland. |
7/04 - 7/07 |
Clinical Pharmacology Statistics Section Leader in the Department for Biostatistics at F. Hoffmann La-Roche AG in Basel, Switzerland. |
4/00 - 6/04 |
Project Statistician in the Department for Biostatistics at F. Hoffmann La-Roche AG in Basel, Switzerland. Working on Phase II, III, and IV clinical trials as well as clinical pharmacology studies in oncology. |
1/98 - 3/00 |
Statistical Scientist in the Preclinical Section of the Biostatistics Department at AstraZeneca in Gothenburg, Sweden. |
3/97 - 12/97 |
Postdoctoral Fellow at the Chair for Applied Statistics of Professor Dr. Friedrich Pukelsheim at the University of Augsburg, Germany. |
9/96 - 2/97 |
Junior Research Fellow at the National Institute of Statistical Sciences, Research Triangle Park, North Carolina, USA. |
9/94 - 8/96 |
Visiting Assistant Professor at the Department of Statistics and Actuarial Science and the Institute for Improvement in Quality and Productivity at the University of Waterloo, Canada. |
11/88 - 8/94 |
Assistant at the Chair for Applied Statistics of Professor Dr. Friedrich Pukelsheim at the University of Augsburg, Germany. |
Projects and consulting experience | |
since 1991 |
Medical Statistics: Ongoing consulting projects with the Institute of Reproductive Medicine in Ulm, Germany, on methods to predict the success of assisted reproduction technologies and other related issues. |
1996 - 1997 |
Drug Discovery: Development of sequential strategies to identify lead compounds in large chemical databases with minimal testing. Participation in a co-operation of the National Institute of Statistical Sciences with GlaxoWellcome in North-Carolina, USA. |
1995 - 1997 |
Environmental
Statistics: Development of cost-optimal prediction
and design strategies for the cleanup of
environmental waste sites. Co-operation with the
Environmental Protection Agency in Las Vegas, USA. Joint work with Professor Dr. William J. Welch. |
1986 - 1987 |
Quality Control:
Introduction of Taguchi's off-line and on-line quality
control principles at the car supplies manufacturer Bosch
in Blaichach, Germany. Statistical design, realization,
and analysis of an experiment to improve the quality of
pressure governors used in electronic fuel injection. Joint work with Professor Dr. Friedrich Pukelsheim. |
Research grants | |
Postdoctoral research grant awarded by the German Research Foundation partially supporting a two year visit at the Department of Statistics and Actuarial Science at the University of Waterloo in Canada. | |
University education | |
11/88 - 12/91 |
PhD-studies at the University of Augsburg, Germany. PhD-thesis on ``A Bayesian approach for the stochastic analysis of computer experiments´´, supervisor: Professor Dr. Friedrich Pukelsheim, final examination on December 19, 1991, degree: Dr. rer. nat. |
10/83 -10/88 |
Masters and undergraduate
studies in mathematics and economics at the University of Augsburg, Germany. Masters thesis on ``Chi-squared type tests for ordered alternatives and Taguchi's accumulation analysis´´, supervisor: Professor Dr. Friedrich Pukelsheim, final examination on October 26, 1988, degree: Dipl.-Math. oec. Univ. |
Teaching experience | |
Spring 1995/ |
Course `Probability´ in the Department of Statistics and Actuarial Science at the University of Waterloo in Canada. |
2005
Capecitabine as adjuvant treatment of stage
III colon cancer. New England Journal of Medicine 352,
2696-2704.
(With C. Twelves, A. Wong,
M. Nowacki , J. Fagerberg, and others.)
Confocal scanning laser microscopy
measurements of atherosclerotic lesions in mice aorta: A fast
evaluation method for volume determinations. Atherosclerosis
179, 35-42.
(With A.-C. Andreasson and
A.-C. Jönsson-Rylander.)
2002
Incidence of cardiotoxicity with the oral
fluoropyrimidine capecitabine is typical of that reported with
5-fluorouracil. Annals of Oncology 13,
484-485.
(With E. van Cutsem, P.M.
Hoff, J.L. Blum, and B. Osterwalder.)
Concentrations below the limit of
quantitation and their effect on the analysis of pharmacokinetic
equivalence trials. Unpublished manuscript.
(With C. Ekman and M.
Cullberg.)
2001
A sequential approach for identifying lead
compounds in large chemical databases. Statistical Science
16, 154-168.
(With Y.-B. Lim, J. Sacks,
M. Xie, and S.S. Young.)
Impact of recombinant follicle-stimulating
hormone and human menopausal gonadotropins on in vitro
fertilization outcome. Fertility and Sterility 75,
332-336.
(With E. Strehler, I.
El-Danasouri, M. DeSanto, and K. Sterzik.)
2000
Predicting the histologic dating of an
endometrial biopsy specimen with the use of Doppler
ultrasonography and hormone measurements in patiemts undergoing
spontaneous ovulatory cycles. Fertility and Sterility 73,
94-98.
(With K. Sterzik,
D. Grab, V. Schneider, and E. Strehler.)
1999
Estimating the prediction mean squared
error in Gaussian stochastic processes with exponential
correlation structure. Scandinavian Journal of Statistics 26,
563-578.
Design and analysis for modeling and
predicting spatial contamination. Mathematical Geology 31,
1-22.
(With W.J. Welch and J.
Sacks.)
1998
Approximating the mean squared prediction
error in linear models under the family of exponential
correlations. Statistica Sinica 8,
511-526.
Fisher information and maximum-likelihood
estimation of covariance parameters in Gaussian stochastic
processes. Canadian Journal of Statistics 26,
127-137.
(With W.J. Welch.)
Optimal designs in growth curve models:
Part II. Correlated model for quadratic growth: Optimal designs
for parameter estimation and growth prediction. Journal of Statistical Planning and Inference 67, 287-296.
(With N. Gaffke, E.P. Liski,
and B.K. Sinha.)
1997
Optimal designs in growth curve models:
Part I. Correlated model for linear growth: Optimal designs for
slope parameter estimation and growth prediction. Journal of Statistical Planning and Inference 64, 141-150.
(With E.P. Liski, N.K. Mandal, and B.K. Sinha.)
FSH-Therapie bei idiopathischer
Oligoasthenotheratozoospermie als Ergänzung zu assistierten
reproduktionsmedizinischen Techniken. Geburtshilfe und
Frauenheilkunde 57, 66-70.
(With E. Strehler, K. Sterzik, M. DeSanto, B.
Rosenbusch, R. Wiedemann, M. Montag, B. Baccetti, and R.
Kreienberg.)
The effect of follicle-stimulating hormone
therapy on sperm quality: An ultrastructural mathematical
evaluation. Journal of Andrology 18,
439-447.
(With E. Strehler, K. Sterzik, M. DeSanto, R.
Wiedemann, U. Bellati, G. Collodel, P. Piomboni, and B.
Baccetti.)
1996
Influence of smoking on fertility in women
attending an in-vitro fertilization program. Fertility and
Sterility 65, 810-814.
(With K. Sterzik, E. Strehler, M. DeSanto, N.
Trumpp, B. Rosenbusch, and A. Schneider.)
1995
Improving manufacturing quality through planned experiments:
Statistical methodology. Surveys on Mathematics for Industry
5, 27-33.
(With F. Pukelsheim.)
Improving manufacturing quality through planned experiments:
Pressure governor case study. Surveys on Mathematics for
Industry 5, 35-47.
(With R. Mayer and F. Pukelsheim.)
Predicting the success of in-vitro
fertilization: Conventional semen analysis compared to the
hamster-ova penetration test. Statistics in Medicine 14,
1807-1818.
(With E. Strehler, K.
Sterzik, and B. Rosenbusch.)
Rauchen - Eine mögliche Ursache für den
Mißerfolg im IVF/ET-Programm? Geburtshilfe und
Frauenheilkunde 55, 532-535.
(With K. Sterzik, E. Strehler, M. DeSanto, N.
Trumpp, B. Rosenbusch, and R. Kreienberg.)
1994
A note on the product correlation rule. Linear
Algebra and its Applications 199, 171-177.
On the product and the sum of random
variables with arithmetic and non-arithmetic distributions. Statistics & Probability Letters 19, 291-297.
In-vitro Kallikrein treatment of human
spermatozoa: Stimulation of sperm penetration into zona-free
hamster eggs depends on the quality of initial semen parameters
but not on constituents of the Kallikrein-Kinin system in seminal
plasma. Journal of Urology 151,
1712-1714.
(With K. Sterzik, E. Strehler, and B.
Rosenbusch.)
1993
Optimal strategies for computer experiments
with uncertain resources. Technical Report No. 450,
Schwerpunktprogramm der Deutschen Forschungsgemeinschaft,
University of Augsburg, 17 pages.
Computer experiments - An example from
Biology. Proceedings of the 8-th European Young Statisticians
Meeting 1, 1-5.
Die Korrelation zwischen zytogenetischen
Anomalien menschlicher Spermatozoen und der Spermienmorphologie
sowie dem Alter der untersuchten Personen. Zentralblatt für
Gynäkologie 115, 113-116.
(With B. Rosenbusch, E.
Strehler, and K. Sterzik.)
1992
Some exact optimal designs for linear
covariance functions in one dimension. Communications in
Statistics - Theory and Methods 21,
2059-2069.
Prediction of log-Gaussian processes and
applications to the cleanup of environmental contaminations. Seminar
of the Austrian-Swiss Region of the International Biometric
Society, St. Gallen, Switzerland, October 2003.
Three Arm Non-Inferiority Studies in
Oncology: Testing for Superiority and Effect Retention, 49.
Biometrisches Kolloquium, Wuppertal, Germany, March 2003.
Non-Inferiority Trials in Oncology, 50-th
Meeting of the Arbeitsgemeinschaft für Pharmazeutische
Forschung, Karlsruhe, Germany, November 2002.
The Assessment of Equivalence in Oncology
Clinical Trials, International Biometric Conference,
Freiburg, Germany, July 2002.
Statistical Models for Structure-Activity
Relationships, Colloquy of the Basel Section of the
International Biometric Society, Basel, Switzerland, October
2000.
Stochastic Process Models for
Structure-Activity Relationships, 2nd International Workshop on Statistical
Methodology in Non-Clinical R&D, Montreux, Switzerland,
September 2000.
Experimental design for quality control: A
case study. Chalmers Technical University, Gothenburg,
Sweden, May 1999.
Modeling quantitative structure activity
relationships using stochastic processes. Conference on Experimental
Design, Theory and Applications, Oberwolfach, Germany,
November 1998.
Sequential experimental design and
contamination cleanup. Bavarian State Office for
Environmental Affairs, Munich, Germany, December 1997.
Compound screening in pre-clinical drug
development: A sequential approach. Conference on Model
Fitting and Mixture Experiments, Irsee, Germany, October
1997.
Prediction of log-Gaussian processes and
applications to the cleanup of environmental contaminations. ISI-Satellite
Meeting, University of Rostock, Germany, September 1997.
Log-Gaussian processes and environmental
applications. Faculty of Mathematics,
Otto-von-Guericke-University of Magdeburg, Germany, July 1997.
General aspects in analyzing large chemical
databases. Department of Biostatistics, Astra Hässle AB, Gothenburg,
Sweden, June 1997.
Approximating the mean squared prediction
error in Gaussian stochastic processes. Department of
Statistics, University of Minnesota, Minneapolis, USA, May
1996.
Site remediation data analysis and
sequential design strategies. With
Professor Dr. William J. Welch. Workshop at
the Environmental Protection Agency, Las Vegas, USA, May
1996.
On the prediction error in Gaussian
stochastic processes. Department of Mathematics,
University of Indiana, Bloomington, USA, April 1996.
Gaussian stochastic processes: Prediction
and approximating the prediction error. Department of
Statistics, Cornell University, Ithaca, USA, December 1995.
Optimal designs for linear and quadratic
growth curve models. Department of Statistics and Actuarial
Science, University of Waterloo, Canada, January 1995.
Growth curve models and related optimal
designs. Department of Statistics, York University,
Canada, December 1994.
Stochastic methods for interpolation. Institute
for Applied Mathematics and Statistics, Technical University
of Munich, Germany, July 1994.
E-optimal designs for linear and
quadratic growth curve models. Pentecost Meeting,
University of Dortmund, Germany, May 1994.
Computer experiments and Bayesian
interpolation. Faculty of Economics, Free University of
Berlin, Germany, May 1994.
Taguchi methods - A case study. Colloquy
on Statistical Methods in Experimental Research, Free
University of Berlin, Germany, November 1993.
A designed experiment for pressure
governors used in electronic fuel injection. Department of
Statistics and Actuarial Science, University of Waterloo,
Canada, October 1993.
On random variables with arithmetic
distributions. Annual Meeting of the Austrian Mathematical
Society, Linz, Austria, September 1993.
Computer experiments - An example from
Biology. 8-th European Young Statisticians Meeting,
Palanga, Lithuania, September 1993.
Design of computer experiments. Conference
on Optimal Design, Oberwolfach, Germany, May 1993.
Exact optimal designs for linear covariance
functions. Annual Meeting of the German Mathematical Society,
Humboldt University of Berlin, Germany, September 1992.
A computer experiment in photosynthesis. Colloquy
of the German Research Foundation, University of Augsburg,
Germany, May 1991.