Creatinine - serumDefinition Creatinine is a breakdown product of creatine, which is an important part of muscle. A serum creatinine test measures the amount of creatinine in the blood. How the test is performed Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic. An elastic band is placed around the upper arm to apply pressure and cause the vein to swell with blood. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. During the procedure, the band is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding. For an infant or young child: The area is cleansed with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on a slide, onto a test strip, or into a small container. A bandage may be applied to the puncture site if there is any bleeding. How to prepare for the test The health care provider may tell you to stop taking certain drugs that may affect the test. How the test will feel When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing. Why the test is performed The test is performed to evaluate kidney function. If kidney function is abnormal, creatinine levels will increase in the blood, due to decreased excretion of creatinine in the urine. Creatinine levels also vary according to a person's size and muscle mass. Normal Values A normal (usual) value is 0.8 to 1.4 mg/dl. Normal value ranges may vary slightly among different laboratories. Females have a lower creatinine than males, because they have less muscle mass. Note: mg/dl = milligrams per deciliter What abnormal results mean For abnormal results, the following applies: Higher-than-normal levels may indicate:
Lower-than-normal levels may indicate:
Additional conditions under which the test may be performed:
What the risks are
Why is the test performed: A measurement of the serum creatinine level is used to evaluate kidney function. Creatinine is a breakdown product of creatine, which is an important component of muscle. Creatinine can be converted to the ATP molecule, which is a high-energy source. The daily production of creatine and subsequently creatinine, depends on muscle mass, which fluctuates very little. Creatinine is excreted from the body entirely by the kidneys. With normal renal excretory function, the serum creatinine level should remain constant and normal. Special considerations Drugs that can increase creatinine measurements include aminoglycosides (for example, gentamicin), Bactrim, cimetidine, heavy metal chemotherapeutic agents (for example, Cisplatin), and nephrotoxic drugs -- such as cephalosporins (for example, cefoxitin). Illustrations
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