Dr. John  Folts, Ph.D., FACC Professor of Medicine, University of Wisconsin School of Medicine Director of the Coronary Artery Thrombosis Research and Prevention Laboratory Ph.D. - Cardiac Physiology             Ph.D. – Pathology             M.Sc. – Physiology             B.S. Electrical Engineering Fellow of the American College of Cardiology Author or co-author of over 110 scientific papers   Accredited for developing the Aspirin model in 1973   Developed the patent pending Flavonoid complex Provex CV that the                                    FDA has recently acknowledge as a new model for heart disease                                     prevention and is presently doing research on this complex. Notes from his 1998 Presentation to the American Dietetic Association The two main factors in Coronary Artery Disease 1. Platelet activity 2. Oxidized LDL cholesterol Looking for something in the diet that would do the following 1. Improve the function of the endothelial cells 2. Turn down the activity of the platelets 3. Protect the LDL cholesterol from oxidation 4. Have anti-inflammatory properties 5. Inhibit clot formation 6. They protect against elevations of Adrenaline- aspirin does not! Methods of measuring platelet activity 50,000 you will bleed easy 300,000 you should be fine 900,000 you are a clotter Platelet activity can be turn up or down in 5—10 minutes -  smoking cigarettes. Flavonoids are micronutrients found in vegetables, fruits and their juices but not in any animal products.  They have no nutritional value because they are not carbohydrates, fats or proteins. Flavonoids protect us against elevations of Adrenaline which aspirin does not.  “In the late seventies it was discovered that if the level of adrenaline (epinephrine) was increased…usually from any type of stress like smoking, heavy exercise or mental stress…75% to 80% of the time the clot formations come back with aspirin…and that is a serious problem.”  Dr. John Folts, Ph.D. “Flavonoids found in red wine, purple grapes juice and tea inhibit platelets about the same as aspirin, but they are not affected by elevations of adrenaline from stress like aspirin does, making them more desirable than aspirin.” Flavonoids will bind to cell membranes and bind to plasma proteins  (tissue loading) Cholesterol in the Test Tube notes from Dr. Folts presentation Amer. Dietetic Ass. “A person with a poor diet…there is no reaction on cholesterol for about 50 minutes…in otherwords there is some protection from LDL cholesterol for about 50 minutes… this is called the LAG TIME…following this lag time there is rapid oxidation of the cholesterol.” “A person with a better diet…who eats more fruits and vegetables increases their lag time up to approximately 100 minutes…then the oxidation is slower.” “A person that takes supplements or a vegetarian who eats lots of fruits and vegetables their lag time increases way out to 150 minutes before the oxidation of LDL cholesterol takes place.” “The longer the lag time, or the longer before the time before LDL starts to oxidize the better off you will be. So, you would like to have antioxidants bound to the cholesterol to protect it in the sub endothelial space.” Problem:  Other supplements have not been tested to show that a: “A given Dose produces a specific measured effect in either animals or                     humans.”   Dr. John Folts--University of Wisconsin   A Patent Pending combination of Grapeseed, Grapeskin, Bilberry, Quercetin and                    Gingko Biloba combined with a specific enzyme blend to make it more                     bioavailable. Reduces collagen-induced platelet activation by 52% Reduces adenosine diphosphate-induced platelet activation by approx. 40% ………………………………………………………………………………………… Atherosclerosis Begins In Adolescence Dr. Jack P. Strong, of Louisiana State University Medical Center, and a multi-center team performed autopsies on 2, 876 individuals between the ages of 15 and 34 who died of external causes to document the extent of atherosclerosis in this age group. Atherosclerotic lesions were apparent in even the youngest subjects, those aged 15 to 19 years, in whom the investigators detected intimal lesions in 100% of the aortas and more than 50% of the right coronary arteries.   These lesions “…increased in prevalence and extent with age through the oldest age group.”   Pathobiological Determinants of Atherosclerosis in Youth study Prevalence and Extent of Atherosclerosis in Adolescents and Young Adults, Journal of the American Medical Association, February 24, 1999 Vol 281. No.8