The Positive Effects of Grape Seed Proanthocyanadins  The family practice professor listed numerous physiological attributes of supplementing one's food supply with proanthocyanadin bioflavonoids from grape seeds in the following order of occurrence:

  Such bioflavonoids decrease tissue inflammation as a result of their inhibition of the body's prostaglandins, kinins, histamine, leukotrienes, 5-HT, and the enzymes lipoxygenase and cyclooxygenase; They decrease allergic reactivity by inhibiting mast cell and basophil degranulation;

  Grape seeds also decrease allergy by their inhibition of histidine decarboxylase thereby depleting tissue levels of histamine; They produce highly effective free radical scavenging and cessation of free radical chain reactions as well as repair of free radical-induced tissue damage;

  The proanthocyanidin bioflavonoids potentiate and regenerate the antioxidant, antithrombotic, anti-inflammatory, and antineoplastic effects of vitamin C (ascorbates) and vitamin E (tocopherols);

  They repair and maintain normal collagen and elastin fiber structure resulting in the strengthening of vasculature. As a result, the grape seed supplement user will experience reduced capillary fragility, less venous
insufficiency, decreased atherosclerosis, resolution of vague swellings, a diminished risk of phlebitis, expedient healing of chronic dermatoses, fewer ulcerations, and protection against skin injury from the sun.