Resources
EBM articles and sessions


JAMA EBM Series:

JAMA publishes a series of articles on Evidence-Based Medicine, known as the Users' Guides to the Medical Literature. As of today (2001 Dec 17), there are 32 articles in the series, and you can find them here.


JAMA Rational Clinical Exam Series:

JAMA also publishes the Rational Clinical Examination series, whose articles teach evidence-based clinical exams.
Click here to enter.


Lancet Epidemiology Series:

Lancet publishes a series of articles on clinical epidemiology written by D. Grimes and K. Schultz. As of May 2002, there are 11 articles in the series, and you can find them here.


EBM Sessions for MacIntMed Residents:

2003 Feb 12, 3pmHalfDay on EBM (Dr. G. Guyatt)
Hu FB, Manson JE, Stampfer MJ, et al.
Diet, Lifestyle, and the Risk of Type 2 Diabetes Mellitus in Women
NEJM 2001 Sep 13; 345(11):790-97.
DMwomen.pdf (112kb)
Scenarios
Feb12scenario.pdf (48kb)

2003 Jan 30, 6pmDr. S. Yusuf
The Heart Protection Study (HPS)
Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebocontrolled trial.
Lancet 2002 Jul 6; 360:7-22.
HPS.pdf (198kb)
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Major Outcomes in High-Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic
JAMA 2002 Dec 18; 288(23):2981-97.
ALLHAT.pdf (288kb)

2002 Dec 11, pmHalfDay on EBM (Dr. G. Guyatt)
Gress TW, Nieto FJ, Shahar E, et al.
Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus
NEJM 2000 Mar 30; 342(13):905-12.
AntiHTN-DM.pdf
Scenarios
AntiHTN-DM-Scenario.pdf

2002 Nov 26, 6pmDr. D. Cook & Dr. S. Capes
Berghe GV, Wouters, P, Weekers F, et al.
Intensive Insulin Therapy in Critically Ill Patients.
NEJM 2001 Nov 8;345(19):1359-67.
InsulinICU.pdf
Rivers E, Nguyen B, Havstad S, et al.
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock.
NEJM 2001 Nov 8;345(19):1368-77.
GoalSepsis.pdf

2002 Sep 25, 3pmHalfDay on EBM (Dr. G. Guyatt)
Wells PS, Brill-Edwards P, Stevens P, et al.
A Novel and Rapid Whole-blood Assay for D-Dimer in Patients with Clinically Suspected Deep Vein Thrombosis.
Circulation 1995;91(8):2184-7.
SimpliRED.pdf
Scenarios
SimpliRED-Scenarios.pdf

2002 Sep 5, 6pmDr. A. Morris & Dr. G. Guyatt
Marrie TJ, Lau CY, Wong CJ, et al.
A Controlled Trial of a Critical Pathway for Treatment of Community-Acquired Pneumonia.
JAMA 2000;283:749-55.
CAPtrial.pdf>
Finch R, Schurmann D, Collins O, et al.
Randomized Controlled Trial of Sequential IV and Oral Moxifloxacin Compared with Sequential IV and Oral Co-Amoxiclav with or without Clarithromycin in Patients with Community-Acquired Pneumonia Requiring Initial Parenteral Treatment
Antimicrob Agents Chemother 2002 Jun;46:1746-54.
CAP.pdf

2002 Jun 6, 7amDr. G. Guyatt (AM Session #8)
Basic statistics for clinicians: 3. Assessing the effects of treatment: measures of association
CMAJ 1995; 152(3):351-357.
EBMstats3.htm
Basic statistics for clinicians: 4. Correlation and regression
CMAJ 1995; 152(4):497-504.
EBMstats4.htm
Example article: PCI-CURE (already posted under Cardiology)
Example article: TRICC Subgroup (already posted below on Feb 7)

2002 May 16, 7amDr. G. Guyatt (AM Session #7)
Basic statistics for clinicians: 1. Hypothesis testing
CMAJ 1995; 152(1):27-32.
EBMstats1.htm
Basic statistics for clinicians: 2. Interpreting study results: confidence intervals
CMAJ 1995; 152(2):169-173.
EBMstats2.htm

2002 Apr 18, 6pmDr. G. Guyatt & Dr. E. Kaminska
Lipsky PE, Van Der Heijde D, St. Clair EW, et al.
Infliximab and methotrexate in the treatment of rheumatoid arthritis.
NEJM 2000;343:1594-602.
RemicadeRA.pdf

2002 Apr 10, 7amDr. G. Guyatt (AM Session #6)
Low-Molecular-Weight Heparins Compared with Unfractionated Heparin for Treatment of Acute Deep Venous Thrombosis:
A Cost-Effectiveness Analysis
Ann Intern Med 1999; 130(10):789-99.
EBM-DVT.pdf (continuation of the Mar 14 Session)

2002 Mar 14, 7amDr. G. Guyatt (AM Session #5)
Low-Molecular-Weight Heparins Compared with Unfractionated Heparin for Treatment of Acute Deep Venous Thrombosis:
A Cost-Effectiveness Analysis
Ann Intern Med 1999; 130(10):789-99.
EBM-DVT.pdf

2002 Feb 7, 6-8pmDr. S. Yusuf & Dr. M. Blajchman
Wu WC, Rathore SS, Wang Y, et al.
Blood transfusion in elderly patients with acute myocardial infarction.
NEJM 2001;345:1230-6.
TransfusionMI.pdf
Hebert PC, Yetisir E, Martin C, et al.
Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases?
Crit Care Med 2001 Sep;29(2):227-234.
Online via MD Consult

2002 Jan 9, 7am Dr. G. Guyatt (AM Session #4)
Kearon C, Ginsberg JS, Douketis J, et al.
Management of Suspected Deep Venous Thrombosis in Outpatients by Using Clinical Assessment and D-Dimer Testing
Ann Int Med 2001 Jul 17; 135(2):108-111.
ddimerDVT.pdf

2001 Dec 5, 7am Dr. G. Guyatt (AM Session #3)
Brophy JM, Joseph L, Rouleau JL.
Beta-Blockers in Congestive Heart Failure: A Bayesian Meta-Analysis
Ann Int Med 2001 Apr 3; 134(7):550-560.
BBinCHF.pdf

2001 Nov 21, 7amDr. G. Guyatt (AM Session #2)
Wardlaw JM, Warlow CP, Counsell C.
Systemic review of evidence on thrombolytic therapy for acute ischemic stroke.
Lancet 1997;350:607-14.
(Unfortunately, the PDF is not available from Lancet.)

2001 Nov 5, 6-8pmDr. M. Crowther & Dr. D. Cook
Bernard GR, Vincent E-L, Laterre P-F, et al.
Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
NEJM 2001 Mar 8; 344(10):699-709.
APC.pdf
Warren BL, Eid A, Singer P, et al.
High-Dose Antithrombin III in Severe Sepsis
JAMA 2001 Oct 17; 286(15):1869-78.
AT3.pdf

2001 Oct 25, 7am Dr. G. Guyatt (AM Session #1)
Lau JYW, Sung JJY, Lee KKC, et al.
Effect of Intravenous Omeprazole on Recurrent Bleeding after Endoscopic Treatment of Bleeding Peptic Ulcers
NEJM 2000 Aug 3; 343(5):310-316.
Lau.pdf




New version created 2001 Dec 1
Last updated 2003 Feb 10
Created & maintained by Bob Yang