| YEAR | ILLINESS | |
| 1657 | Boston Measles | |
| 1687 | Boston Measles | |
| 1690 | New York, Yellow Fever | |
| 1713 | Boston Measles | |
| 1729 | Boston Measles | |
| 1732-3 | Worldwide Influenza | |
| 1738 | South Carolina Smallpox | |
| 1739 | Boston Measles | |
| 1747 | CT., NY., PA., S.C., Measles | |
| 1759 | North America (areas inhabited by white people) Measles | |
| 1760 | North American & West Indies Influenza | |
| 1772 | North American Measles | |
| 1775 | North American Measles | |
| 1775-6 | Workdwide Influenza (One of the worst epidemics) | |
| 1783 | Dover, De., Bilious Disorder (extremely fatel) | |
| 1788 | Philadelphia and New York Measles | |
| 1793 | Vermont, a "Putrid" Fever and Influenza | |
| 1793 | Philadelphia, Yellow Fever (One of the worst epidemics) | |
| 1793 | Harrisburg, Pa., Unknown (Many unexplained deaths) | |
| 1793 | Middletown, Pa., Unknown (Many unexplained deaths) | |
| 1794 | Virginia Influenza (killed 500 in 5 counties in 4 weeks) | |
| 1794 | Philadelphia, Pa., Yellow Fever | |
| 1796-7 | Philadelphia, Pa., Yellow Fever | |
| 1798 | Philadelphia, Pa., Yellow Fever (One of the worst) | |
| 1803 | New York Yellow Fever | |
| 1820-3 | Nationwide Fever (Starts at Schuylkill River and spreads) | |
| 1831-2 | Nationwide Asiatic Cholera (Brought by English emigrants) | |
| 1832 | New York City and other major cities, Cholera | |
| 1833 | Columbus, Ohio, Cholera | |
| 1834 | New York City, Cholera | |
| 1837 | Philadelphia, Typhus | |
| 1841 | Nationwide Yellow Fever (Especially severe in the south) | |
| 1847 | New Orleans, Yellow Fever | |
| 1847-8 | Worldwide Influenza | |
| 1848-9 | North American Cholera | |
| 1849 | New York, Cholera | |
| 1850 | Nationwide Yellow Fever | |
| 1850-1 | North American Influenza | |
| 1851 | Coles Co, Ill., The great Plains and Missouri, Cholera | |
| 1852 | Nationwide Yellow Fever (New Orleans, 8000 die in summer) | |
| 1855 | Nationwide Yellow Fever | |
| 1857-9 | Worldwide Influenza (One of the largerst epidemics) | |
| 1860-1 | Pennsylvania, Smallpox | |
| 1865-73 | Philadelphia, N. Y., Boston, New Orleans, Smallpox, Baltimore, Memphis, Washington D.C., Cholera and a series of recurring epidemics of Typhus, Typhoid, Scarlet Fever and Yellow Fever | |
| 1878 | New Orleans Yellow Fever ( Last greqt Epidemic) | |
| 1885 | Plymouth, Pa., Typhoid | |
| 1886 | Jacksonville, Florida, Yellow Fever | |
| 1918 | Influenza (Worldwide more people were hospitalized in WW1 from this epidemic than wounds. US Army training camps became death camps, with 80% dewath rate in some camps. |