SONYA BLADE
Sonya kicked all of the Mortal Kombatants in the asses to get this slot!

Games:Mortal Kombats (all I believe though not playable in 2)
Why: Sonya is one of the classic fighting female characters. The fact that they gave her a death kiss gives her the title of "Femme Fatale" and she has been ressurected in numerous games. Let's just say almost any female character that can kill others was most likely derived from Sonya's originality!