Anytime...

Gloria starts spewing medical-babble, say "Yeah ... what she said" and drink.

Gloria looks to the heavens in frustration, drink and resume the game as Said.

Gloria looks at Ryan with contempt, say "Stop fighting it! Just give in!" and drink.

Gloria says Ryan's name (first, last, or both) sing the chorus to "Can't Fight This Feeling" by REO Speedwagon and drink.

Ryan and Gloria actually knock da books (even if it's just a fantasy sequence,) find the biggest bottle of whiskey you can get your hands on, grab your tissues, proclaim "God, that's SO BEAUTIFUL!" and drink yourself silly.