Anytime...

Vern calls someone "sweetpea," "cupcake," "sweetcheeks" or any other disgusting endearment, take a drink.

Someone gets a piece of mail delivered by the King of Hell himself, take a drink. If it's a package, take two. If it's from a  loved one and Vern's obviously already opened it ('cause he knows what's inside,) take three long swigs and spit at the screen.

Vern and Said get into an eyefuck contest, take a drink per second of unbroken staring.

Vern and Beecher snipe at each other like an old (divorced) couple, take one drink per bitchy comment.

Vern flutters his eyelashes or camps up his voice, drink something with fruit in it.

Vern is on screen and makes a racist remark or says something to do with revenge on Beecher, drink.

Vern is on screen and doesn't make a racist remark or say something to do with revenge on Beecher, drink the whole pint in one shot.