Selected peer-reviewed research publications

 

Synthesis of N6,N6-Dialkyladenine Nucleosides Using Hexaalkylphosphrous Triamides Produced in Situ. M. K. Lakshman, A. Choudhury, S. Bae, E. Rochttis, P. Pradhan and A. Kumar (2009), Euro. J. Org. Chem. 152-159. [View Article]

 

Palladium-Catalyzed Synthesis of Nucleoside Adducts from Bay and Fjord Region Diol Epoxides. E. Champeil, P. Pradhan and M. K. Lakshman (2007) J. Org. Chem. 72(14) pp 5035 – 5045. [View Article]

 

Highly diastereoselective synthesis of nucleoside adducts from the carcinogenic benzo[a]pyrene diol epoxide and a computational analysis. M. K. Lakshman, J. C. Keeler, F. N. Ngassa, J. H. Hilmer, P. Pradhan, B. Zajc and K. A. Thomasson (2007) J. Am. Chem. Soc., 129, 68-76. [View Article]

 

Voltage gating and anions, especially phosphate: A model peptide. P. Pradhan, R. Ghose and M. E. Green (2005) Biochim. Biophys Acta. (2005) 1717, 97-103. [View Article]

 

Synthesis and Reactions of 2-Chloro- and 2-Tosyloxy-2'-deoxyinosine Derivatives. N. Pottabathini,  S. Bae, P. Pradhan,  H. Hanh, H.  Mah and M. Lakshman (2005), J. Org. Chem. 70(18); 7188-7195. [View Article]

 

Mild and Room Temperature C-C bond forming reactions of nucleoside C-6 arylsulphonates, M. K. Lakshman, P. Gunda and P. Pradhan. (2005) J. Org. Chem. 70 (25), 10329-10335 [View Article]

 

NMR solution structure of an oxaliplatin 1,2-d(GG) intrastrand cross-link in a DNA dodecamer duplex. Y. Wu Y, P. Pradhan, J. Havener, G. Boysen, J. A. Swenberg, S. L. Campbell, S. G. Chaney. (2004) J Mol Biol. 341(5):1251-69. [View Article]

 

Mutagenesis of the Runt Domain Defines Two Energetic Hot Spots for Heterodimerization with the Core Binding Factor Subunit.  Lina Zhang , Zhe Li , Jiangli Yan , Padmanava Pradhan , Takeshi Corpora, Matthew D. Cheney , Jerónimo Bravo, Alan J. Warren, John H. Bushweller and Nancy A. Speck (2003) J. Biol. Chem., 278, Issue 35, 33097-33104. [View Entrez Listing]

 

A novel intramolecular arene–alkene photocycloaddition in 2-alkenyl naphtha-4-chromanones––a short route to functionalised multicyclic systems.  Govind P. Kalenaa, Padmanava Pradhana, Vedavati S. Puranikb and Asoke Banerji (2003) Tetrahedron Letters, 44, 2011-2013. [View Science Direct Listing]

 

MQ-HCN-based Pulse Sequences for the Measurement of C1'-H1', C1'-N, H1'-N,C1'-C2', H1'-C2', C6/8-H6/8, C6/8-N, H6/8-N, C6-C5, H6-C5 Dipolar Couplings in 13C,15N-labeled DNA (and RNA).  Jiangli Yan, Takeshi Corpora, Padmanava Pradhan, and John H. Bushweller (2001) J. Biomol. NMR, 22, 9-20. [View Entrez Listing]

 

Solution Structure of a Trans Opened (10S)-dA Adduct of (+)-(7S,8R,9S,10R)-7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in a Fully Complementary DNA Duplex:  Evidence for a Major Syn Conformation; P. Pradhan, S. Tirumala, X. Liu, J. Sayer, D. M. Jerina and H. J. C. Yeh. Biochemistry. 40, 5770-5881 (2001). [View Entrez Listing]

 

“NMR Solution Structures of Undecanucleotide Duplexes with Thymidine Base Opposite (10R)‑Adducts Derived from Trans Addition of Deoxyadenosine N6‑Amino Group to (‑)‑(9R,10S)‑9,10‑epoxy‑7,8,9,10‑ tetrahydrobenzo[a]pyrene and its (‑)‑ (7S,8R,9R,10S)‑7,8‑Dihydroxy analogue”; P. Pradhan, X. Liu, J. Sayer, M. K. Lakshman, J. H. Shah, D. M. Jerina and H. J. C. Yeh. (manuscript).

 

Solution Conformations and Base Pair Opening Dynamics of the trans N2-dG adduct derived from 10S (+)-anti-Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and 5'-d(CCTATAGATATCC).d(GGATATCTATAGG), a 13-mer oligonucleotide duplex; P. Pradhan, B. Jernström, A. Seidel, M. Leijon and A. Gräslund (manuscript)

 

Implications of Cytosine Methylation on (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide N2-dG Adduct formation in 5'-d(CGT), 5'-d(CGA) and 5'-d(CGC)  sequence contexts of single- and double-Stranded oligonucleotides; P. Pradhan, A. Gräslund, A. Seidel, and B. Jernström, Chem. Res. Toxicol.  12, 816-821 (1999). [View Entrez Listing]  

 

Stereo- and Regioselectivity of Intramolecular 1,2-Aren-Alkene Photocycloaddition in 2-Alkenyl-4-Chromanones; G. P. Kalena, P. Pradhan, and A. Banerji, Tetrahedron (spl. issue). 55, 3209-3218 (1999).[View Science Direct Listing]

 

on the adduct heterogeneity of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and uv absorption spectroscopy; P. Pradhan, B. Jernström, A. Seidel, B. Nordén and A. Gräslund. Chem. Res. Toxicol.  12, 403-411 (1999). [View Entrez Listing]

 

Studies on adduct formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide with 5'- d(CCTATCGTTATCC) and 5'- d(CCTATCm5GTTATCC) oligonucleotides; P. Pradhan, A. Gräslund, A. seidel and B. Jernström. Polycyclic Aromatic Hydrocarbons. 17, 21-32 (1999).

 

Induced circular dichroism of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides and equilibrium dynamics between groove binding and intercalative binding conformations; P. Pradhan, B. Jernström, A. Seidel, B. Nordén and A. Gräslund. Biochemistry. 37, 4664-4673 (1998). [View Entrez Listing]

 

Novel Cyclobutane fused Furochromone Oligomers from the seeds of Pimpinella monoica Dalz; P. Pradhan and A. Banerji, Tetrahedron. 54, 14541-14548 (1998).[View Science Direct Listing]

 

Intramolecular Photorearrangement of a 2-alkenyl-4-chromanone to an oxapentacyclotetradecanedione; G. P. Kalena, P. Pradhan, Swarnalata, T. P singh, and Asoke Banerji, Tetrahedron Letts. 38, 5551-5554 (1997).[View Science Direct Listing]

 

Stereochmical Assignment of Tertiary Hydroxyl Group in Diterpene Furan Glycosides by Pyridine Induced Shifts, 13C- and 2D-NMR Spectroscopy; P. Pradhan, Vijay D. Gangan, Arjun. T. Sipahimalani and Asoke. Banerji, Spectroscopy Letts. 30(7), 1467-1474  (1997).

 

Stereochemistry of Diastereomeric Neolignans from Piper hookeri by NMR spectroscopy; P. Pradhan and A. Banerji, Phytochemical Analysis. 9(2), 71-74 (1997).

 

Electron donor-acceptor interactions of C60 ,with n- and p-donors: A rational approach towards its solubility; S. Talukdar, P. Pradhan and A. Banerji, Full. Sc. & Tech. 5 (3), 547-557 (1997).

 

N-trans-feruloyltyramine from Tinospora cordifolia, V. D. Gangan, P. Pradhan, A. T. Sipahimalani et.al; Ind. J. Chem.Sect.B., 36B, 837-839 (1997).

 

A new strongly flow birefringent surfactant system; B. K. Mishra, S. D. Samant, P. Pradhan, S. B. Mishra and C. Manohar; Langumuir, 9, 894-898 (1993).

 

Multinuclear Magnetic Resonance Studies of Aluminium Chelates Part I: Chelates with Catechol and Tiron; S. N. Mhatre, S. B. Karweer, P. Pradhan, R. K. Iyer and P. N. Moorty; J. Chem. Soc. Dalton Trans. 3711-3716 (1994).[View Entrez Listing]

 

Two New Norditerpene Furan Glycosides from Tinospora cordifolia; V. D. Gangan, P. Pradhan, A. T. Sipahimalani and A. Banerji; Phytochemistry, 39, 1139-1142 (1995).[View Science Direct Listing]

 

Cordifolisides A, B, C: Furanoid Norditerpene glycosides from Tinospora cordifolia; V. D. Gangan, P. Pradhan, A. T. Sipahimalani and A. Banerji; Phytochemistry, 37, 781-786 (1994). [View Entrez Listing]

 

Pimolin, A New Class of Natural Products, A Naturally Occuring Furochromone Dimer from Pimpinella monoica; P. Pradhan, D. L. Luthria and A. Banerji; Bio Org. and Med. Chem. Letts. 4, 2425 – 2428 (1994).[View Science Direct Listing]

 

(1a, 3a,11a)-2,2,11-trimethyl-14-oxatetra-cyclo[6.5.0.17,11.03,8]tetradec-6-ene-5,9-dione; V. Kabaleswaran, S. S. Rajan, G. P. Kalena, P. Pradhan and A. Banerji, Acta. Cryst. Sec. C. C51, 1981-1883 (1996).

 

Phytoecdysones from Tinospora cordifolia: Structural elucidation of ecdysterone and makisterone A by 2D NMR spectroscopy; V. D. Gangan, P. Pradhan and A. T. Sipahimalani; Ind. J. Chem.Sect.B. 36B, 787-792 (1997).[View Science Direct Listing]

 

Palmitosides C and F: Furan Diterpene Glycosides from Tinospora cordifolia: Structural Elucidation by 2D NMR Spectroscopy; V. D. Gangan, P. Pradhan, A. T. Sipahimalani and A. Banerji; Ind. J. Chem.Sect.B, 35B, 630-634 (1996).

 

Neolignans  of Indian Piper species: structure of hookerinone A, a novel neolignan; P. Pradhan, S. J. Desai, L. P. Badheka and A. Banerji, Nat. Prod. Letts. 4, 35-42 (1994).

 

Tomentonone, a new xanthonoid from the stem bark of Calophyllum tomentosum; A. Banerji, A. D. Deshpande, B. R. Prabhu and P. Pradhan; J. Nat. Prod. 57, 396-399 (1994).

 

Stereochemistry of a guaianolide from Cyathocline purpurea by high resolution NMR; P. Pradhan, G. J. Chintalwar and A. Banerji; Spectroscopy Letts. 26, 997-1004 (1993).

 

A novel intramolecular 1,2-arene-alkene photocycloaddition; G. P. Kalena, P. Pradhan and A. Banerji; Tetrahedron Letts. 33, 7775-7778 (1992).

 

Structure of zeyloxanthonone (wightianone) - A reinvestigation; A. Banerji, A. D. Deshpande and  P. Pradhan, Tetrahedron Lett.; 32, 4995-4998 (1991).[View Science Direct Listing]

 

.  Methyl Picrotoxate, A minor component of berries of plant Anamirta cocculus and its stereochemistry by high resolution NMR spectroscopy; P. Pradhan, A.T.  Sipahimalani, and V.R. Mamdapur; Indian J.Chem. Sect.B. 29B, 676-677 (1990).

 

Two Phytoecdysones from Tinospora cordifolia: Structural Assignments by 2D NMR spectroscopy; P. Pradhan, V. D. Gangan, A. T. Sipahimalani and A. Banerji, Ind. J. Chem.Sect.B., 36B, 958-962 (1997).

 

2D-NMR spectroscopy in structure elucidation of natural products;  A.  Banerji, A. D.  Deshpande, D. L. Luthria and P. Pradhan; Proceedings of the symposium on natural product chemistry; Peredenia University, Srilanka, 1991.

 

Piperaceae Alkaloids from Piper hookeri: Revision of NMR Assignments by the Application of 2D NMR Spectroscopy; P. Pradhan, V. D. Gangan, L. P. Badheka and A. Banerji, Indian J.Chem. Sect.B (manuscript).

 

Multinuclear Magnetic Resonance Studies on Aluminium Chelates. Part II. Chelates with 2-Hydroxybenzoic Acid and 3-Carboxy-4-hydroxybenzene Sulphonic Acid; R. K. Iyer, S. N. Mhatre; P. Pradhan and P. N. Moorthy. (manuscript).

 

“Novel multicyclic compounds via intramolecular arene alkene photocyclisation”. P. Pradhan, G. Kalena and A. Banerji. In New Horizons in Organic Synthesis, Eds. V. Nair and S. Kumar, New Age International (P) Ltd. Publishers, New Delhi (1997); p. 222-227

 

List of publications in International Conferences and Proceedings

 

1.     “NMR Solution Structures of Undecanucleotide Duplexes with Thymidine Base Opposite (10R)‑Adducts Derived from Trans Addition of Deoxyadenosine N6‑Amino Group to (‑)‑(9R,10S)‑9,10‑epoxy‑7,8,9,10‑ tetrahydrobenzo[a]pyrene and its (‑)‑ (7S,8R,9R,10S)‑7,8‑Dihydroxy analogue”. P. Pradhan, X. Liu, J. Sayer, M. K. Lakshman, J. H. Shah, D. M. Jerina and H. J. C. Yeh. 218th American Chemical Society Meeting, 22-26 Aug, 1999, Ref. Phys 248, pp. 126, New Orleans, LA, USA.

2.     "Studies on the (+)-trans-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-deoxyguanosine adduct in a 5'- d(CCTATAGATATCC) oligonucleotide duplex by NMR"; P. Pradhan, B. Jernström and A. Gräslund; 16th Intenational Symposium on Polycyclic Aromatic Compounds, November 4-7, 1997, Charlotte, North Carolina, USA.

3.     "Studies on the adduct formation of (+)-trans-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-deoxyguanosine to 5'- d(CCTATCGTTATCC) and 5'-d(CCTATCmethylGTTATCC) oligonucleotide duplexes"; P. Pradhan, B. Jernström and A. Gräslund; 16th Intenational Symposium on Polycyclic Aromatic Compounds, November 4-7, 1997, Charlotte, North Carolina, USA.

4.     "NMR Solution Structure of the  (+)-trans-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-deoxyguanosine adduct in a 5'- d(CCTATAGATATCC)/3´-d(GGATATCTATAGG) oligonucleotide duplex"; P. Pradhan, B. Jernström and A. Gräslund, Nordic NMR symposium, Carlberg Laboratoty, Copenhagen, Denmark, 28-30 May, 1997, Ref. H.28.

5.     "Pimpinella monoica: A Source of Novel Natural Products"; P. Pradhan and A. Banerji; 5th International Symposium on Progress in Natural Product Chemistry, Nottingham University, UK, 15-18 July, 1996, ref. P.14.

6.     "Bio-Active Compounds of Tinospora cordifolia"; V. D. Gangan, A. T. Sipahimalani, P. Pradhan, A. Banerji, P. F. Sumariwalla and K. B. Sainis, 2nd International Symposium on Innovations in Pharmacutical Sciences and Technology, Ahmedabad, India, 25-27 February, 1994.

7.     "Novel  phototransformation  of cannabinoid synthons"; P. Pradhan, G. P. Kalena  and  A. Banerji;  Xth annual conference of Indian Council of Chemists; Goa Univ., 28-30 Oct., 1991, pp. 155, Ref. P-25.

8.     "Structural elucidation by 2D-NMR spectroscopy"; P. Pradhan, G. P. Kalena and A. Banerji; 4th National symposium on Bio-Organic Chemistry; B. A. R. C., Bombay, 27-29 Jan., 1992, pp. 45, Ref. P-25.

9.     "Novel Multicyclic Compounds via Intramolecular  Arene-alkene  Photocycloaddition", G. P. Kalena, P. Pradhan and A. Banerji; IUPAC-POST ICOS-10 Symposium on New Horizons in Organic Synthesis, RRL, Trivendrum, INDIA,  19-20 Dec., 1994, pp. 23, Ref. P-6.

10.  "Novel Natural Products from Pimpenella monoica"; P. Pradhan and A. Banerji; International Symposium on Perspectives in Bio-Organic Chemistry, New Delhi, India, 8-9 Dec., 1994, pp.35. Ref. SL-8.