Department of Chemistry,
City College of CUNY,
J1201, Marshak Building,
138th Street at Convent Avenue,
New York, NY
10031
Phone: (212) 650-6107; Fax: (212) 650-6107
Email: ppradhan@sci.ccny.cuny.edu
Web Site: http://www.oocities.org/padup
Career
Objectives: Structure based drug design; Research in structural
studies of proteins, DNA and organic compounds by multidimensional NMR
spectroscopy, molecular modeling and energy calculations; Natural Products and
Synthesis of biologically active organic compounds.
1.
NMR Scientist and Associate Higher Education
Officer (2002-present): Dept. Chemistry, City College of CUNY, 138th
Street at Convent Avenue, New York, NY 10031
Responsibilities: Managing NMR facility; Structural studies of Proteins and DNA by utilizing NMR and molecular modeling techniques.
2.
Post-Doctoral Research Associate (2002):
Dept. of Biochemistry and Biophysics,University of North Carolina at Chapel
Hill, 517 Mary Ellen Jones Building, Chapel Hill, NC 27599-7260 USA
Responsibilities: NMR and molecular modeling techniques to study the conformation of DNA adducts with different platinum based cancer drugs, viz. oxaliplatin and cisplatin.
3.
Research
Associate (2000 -2002): Dept. of Molecular Physiology and Biological
Physics, University of Charlottesville Health System, Viriginia-22908 USA.
Responsibilities: Structural elucidation of protein-DNA complex by 3D-NMR spectroscopy and molecular modeling and energy minimization; Isolation and purification of proteins; maintenance of NMR spectrometer and training. Structure based drug design.
4.
Research
Fellow (1998-2000): Laboratory of Bio Organic Chemistry, NIDDK,
National Institutes of Health, Bethesda, Maryland, 20892 USA.
Responsibilities: Structural
elucidation of covalent DNA and polycyclic hydrocarbon adducts by 2D-NMR
spectroscopy and molecular modeling, restrained molecular dynamics and energy
minimization; Synthesis oligo-nucleotide adducts, chromatographic purification.
and characterization; NMR software and workstation maintenance and
trainings;
5.
Guest
Researcher (on sabbatical)(1996-1997): Dept of Biophysics,
Arrhenious Laboratory, Stockholm University, s-106 91 Stockholm, Sweden.
Responsibilities: Synthesis of
oligo-nucleotide adducts and there purification; Structural studies of covalent
DNA-carcinogen adducts by 2D-NMR, molecular modeling and energy minimisation.
Structural studies of DNA adducts and optical (CD, Induced CD and Ultraviolet)
spectroscopy; NMR maintenance.
6.
Scientific
Officer (1986-1998): Bioorganic Division, B.A.R.C, Mumbai - 400 085,
India.
Responsibilities: Synthesis of potential pharmaceuticals. Isolation, purification and structural elucidations of plant natural products by NMR and other molecular spectroscopy; Medicinal plants studied, Pimpinela monoica Daltz, Piper hookeri, Cyathocline purpurea, Tinospora cordifolia, momordica charantia etc. Structural studies of complex natural products and synthetic organic compounds; Management of NMR Facility for the division, training for user, supervised projects;
Ph. D.
(1994): Organic Chemistry, University of Bombay, India
(Applications of 2D NMR Spectroscopy for the Elucidation of Structure of
Complex Organic Compounds, Isolation and characterization of Natural Products,
synthesis by intramolecular arene-alkene cyclization)
Master
of Science (1984): Chemistry (subjects: Advanced Organic, Inorganic
and Physical Chemistry), Utkal University, Bhubaneswar, India.
Bachelors
of Science (1982): Chemistry Honors, (other subjects Physics,
Mathematics), Utkal University, Bhubaneswar, India.
Principles
of Clinical Pharmacology (1999-2000): The Warren Grant Magnuson Clinical Center, NIH,
Bethesda, Maryland, USA.
Summer
Course in 2D NMR spectroscopy (1990) by Bruker India at North Eastern Hill University, Shillong, India.
Introductory
Course in 2D NMR Spectroscopy (1987), Dept. Chem. Phys., TIFR, Bombay, India.
One
year Orientation course in Chemistry Research (1985), DAE
training School, BARC, and Bombay, India.
Professional
Membership:
Member, American Chemical Society, Washington D.C. (USA)
Graduate Member of Royal Society of Chemistry, London
(UK)
Life Member, Indian Chemical Society, Calcutta (India)
Technical
Experiences
High
field Multidimensional NMR: Worked with 600 and 500 MHz, Varian-Unity Plus,
500 and 200 MHz-Bruker NMR; NMR Soft wares:
FELIX, XEASY, NMRPIPE, Management of 200 MHz Bruker AC instrument and
workstation
Computer
Skills: Hardware Platforms; Silicon Graphics, Sun, Windows and
Mac-PC.
Operating Systems; UNIX; Software Languages: C, JAVA and Visual Basics.
Molecular
Modeling Software: INSIGHTII, DISCOVER, IRMA, XPLOR
Molecular Modeling and Viewing software: INSIGHTII,
MIDASPLUS, MOLMOL, RASMOL.
Organic Synthesis using light and microwave
radiations, isolation of natural products, and purification of proteins and
DNA.
Separation
Techniques: Well acquainted with Chromatographic methods (SDS-PAGE
GEL electrophoresis, exclusion, affinity and exclusion chromatography, HPLC,
Column Chromatography, GC-MS, TLC)
Spectroscopy: MS,
FTIR, CD, NMR and UV.
Teaching Experiences
Taught and demonstrated NMR spectroscopy to trainees and
Supervised students on NMR related projects for students (R. Prasanna and
P.A.Hasan) in BARC Training School, Bombay, India
Fellowships
and Awards
Research
Associate Fellowship at University of Virginia: 2000 onwards
Post-Doctoral
Fellowship at NIDDK, National Institutes of Health, Maryland: 1998-2000
PD Fellowship at Stockholm University and Karolinska
Institute, Stockholm: 1996-1997
Research Training Fellowship at BARC: 1985-86; CSIR (India) felowship: 1985
Research Fellowship, CSIR, India: 1985 and National
(India) Merit Scholarship: 1978-84
Number of publications (in International Scientific
journals): 32
International Conferences Attended in: USA, Denmark, UK,
India and Sweden.