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Prostaglandin H2 synthase-1

Structure of the Prostaglandin H2 synthase-1 homo-dimer:

EGF-like domain (blue), amphipathic membrane binding motif (red), catalytic globular domain (grey), heme groups (brown), and arachidonic acid in its binding site (yellow). (1)

Introduction

Structural analysis

Homology to other proteins

Structural comparison

3-D structures of PGHS-1 (Rasmol)

Arachidonic acid bound to COX channel

Iodosuprofen(inhibitor) bound to PGHS-1

References

 

This website was created by Rima Estephan for a graduate Enzymology class

Proff. : Dr. Manfred Filipp

Institute: Graduate School and University Center / CUNY

last updated on 6/01/01

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