On June 1, 1936, Sr. Suzanne SPC, Sr. Salvacion SPC, Fr. Florencio de Leseun, OFMCap., and Mrs. Maria Gutierrez founded a charitable learning institution – the Immaculate Conception Institute.  This marked the beginning of St. Anthony School and its devotion to Mary, the Immaculate Conception.  The Institute had its humble beginnings offering kindergarten, primary and intermediate elementary education, with only four teachers and a directress-principal.  Three more teachers were added in 1938 due to an increase in the school population.  The school plant consisted only of a two-storey wooden structure, a canteen, a clinic, a library and a laboratory. 

World War II (1942) and the Japanese Occupation temporarily disrupted the classes.  In 1945, during the liberation, the school building was totally damaged by the fire.  But this did not stop the school from pursuing.  In 1946, the school was re-opened.  Classes were held at the ground floor of the convent of the Capuchins and in rented rooms in different houses along Dart and Anakbayan streets.  The teachers went house to house and invited the parents to send their children to school.  Public School teachers from Pasay came to help out in the afternoon classes.  Elementary Education was offered.  The sisters of St. Paul of Chartres and their lay collaborators took the task of rehabilitating the school during these postwar years.  Under the support and guidance of their Capuchin Pastor, the pupils and teachers help in the Parish celebrations of the Eucharist and devoted themselves to learning.  

The school developed under the administration of the sisters that in 1948, the government under the name Singalong Parochial School officially recognized the school.  In 1956, the Sisters of St. Paul of Chartres formally turned over the newly developed school to the administration of the Capuchin Fathers and continued to assist them in the administration of the school.  A three-storey building was constructed in 1959 through the effort of Archbishop of Manila, the Capuchins, the St. Paul Sisters and the parish community.  

The year 1960 marked the expansion of the school.  The High School Department was opened.  Singalong Parochial School earned popularity for offering quality education.  In 1961 the school’s name was changed to St. Anthony School in honor of the patron saint of the parish.  

Through the years, the school continues to make waves in the academic circles and produce successful graduates in various disciplines.  The school also expanded both in size and number.  St. Anthony School continuously moved on to effect changes to its academic community providing quality education responsive to the needs of the times.  

The Capuchins formally turned over the administration of the school to the Diocesans so that they may concentrate on their mission work.  On April 1, 1995, under the jurisdiction of His Eminence Jaime Cardinal Sin, the first Diocesan Priest was appointed as Parish Priest-Director of St. Anthony.  With these new developments, the school looks forward to the pursuit of its goals to become a fully integrated Catholic center of learning and evangelization.