| PASSING | TM | ATT | COM | PCT | YDS | YPA | TD | TD % | INT | INT % | RAT |
| Babe Parilli | BOS | 356 | 206 | 57.9% | 2668 | 7.5 | 16 | 4.5% | 15 | 4.2% | 79.0 |
| Len Dawson | DAT | 263 | 146 | 55.5% | 1769 | 6.7 | 14 | 5.3% | 15 | 5.7% | 70.4 |
| Frank Tripucka | DEN | 323 | 160 | 49.5% | 1916 | 5.9 | 12 | 3.7% | 18 | 5.6% | 57.2 |
| George Blanda | HOU | 337 | 156 | 46.3% | 1799 | 5.3 | 11 | 3.3% | 36 | 10.7% | 34.2 |
| Johnny Green | NYT | 254 | 120 | 47.2% | 1440 | 5.7 | 5 | 2.0% | 28 | 11.0% | 32.1 |
| Butch Songin | NYT | 47 | 25 | 53.2% | 294 | 6.3 | 2 | 4.3% | 0 | 0.0% | 86.7 |
| Tom Yewcic | BOS | 20 | 11 | 55.0% | 154 | 7.7 | 2 | 10.0% | 2 | 10.0% | 73.8 |
| Jack Kemp | BUF | 119 | 66 | 55.5% | 940 | 7.9 | 5 | 4.2% | 8 | 6.7% | 67.2 |
| Don Heinrich | OAK | 47 | 22 | 46.8% | 298 | 6.3 | 1 | 2.1% | 2 | 4.3% | 56.9 |
| Dick Wood | SDA | 108 | 62 | 57.4% | 801 | 7.4 | 4 | 3.7% | 10 | 9.3% | 54.6 |
| Harold Stephens | NYT | 21 | 8 | 38.1% | 121 | 5.8 | 1 | 4.8% | 1 | 4.8% | 53.9 |
| Hunter Enis | OAK | 67 | 30 | 44.8% | 335 | 5.0 | 2 | 3.0% | 3 | 4.5% | 51.5 |
| George Shaw | DEN | 39 | 22 | 56.4% | 229 | 5.9 | 2 | 5.1% | 4 | 10.3% | 51.1 |
| Lee Grosscup | NYT | 51 | 20 | 39.2% | 311 | 6.1 | 2 | 3.9% | 3 | 5.9% | 48.7 |
| Al Dorow | BUF | 59 | 29 | 49.2% | 382 | 6.5 | 1 | 1.7% | 4 | 6.8% | 47.4 |
| Cotton Davidson | OAK | 146 | 64 | 43.8% | 676 | 4.6 | 6 | 4.1% | 11 | 7.5% | 40.2 |
| Chon Gallegos | OAK | 51 | 24 | 47.1% | 252 | 4.9 | 1 | 2.0% | 6 | 11.8% | 28.8 |
| Warren Rabb | BUF | 140 | 56 | 40.0% | 627 | 4.5 | 6 | 4.3% | 14 | 10.0% | 28.8 |
| John Hadl | SDA | 159 | 69 | 43.4% | 688 | 4.3 | 1 | 0.6% | 20 | 12.6% | 18.8 |