| RUSHING | ATT | YDS | YPC | TD | LG | |
| Abner Haynes | DAT | 207 | 864 | 4.2 | 5 | 66 |
| Clem Daniels | OAK | 206 | 864 | 4.2 | 4 | 43 |
| Keith Lincoln | SDA | 183 | 831 | 4.5 | 3 | 40 |
| Dick Christy | NYT | 170 | 812 | 4.8 | 9 | 47 |
| Charley Tolar | HOU | 174 | 792 | 4.6 | 6 | 25 |
| Curtis McClinton | DAT | 160 | 780 | 4.9 | 3 | 30 |
| Cookie Gilchrist | BUF | 178 | 771 | 4.3 | 4 | 44 |
| Donnie Stone | DEN | 154 | 735 | 4.8 | 0 | 27 |
| Wayne Crow | BUF | 98 | 506 | 5.2 | 5 | 52 |
| Ron Burton | BOS | 116 | 476 | 4.1 | 4 | 20 |
| Billy Cannon | HOU | 83 | 363 | 4.4 | 1 | 67 |
| Bobby Jackson | SDA | 97 | 363 | 3.7 | 3 | 19 |
| Larry Garron | BOS | 64 | 328 | 5.1 | 2 | 41 |
| Jim Crawford | BOS | 111 | 301 | 2.7 | 1 | 19 |
| Bill Mathis | NYT | 76 | 301 | 4.0 | 2 | 27 |
| Bo Roberson | OAK | 95 | 275 | 2.9 | 1 | 16 |
| Wray Carlton | BUF | 78 | 258 | 3.3 | 4 | 16 |
| Dave W. Smith | HOU | 54 | 254 | 4.7 | 4 | 20 |
| Bo Dickinson | DEN | 59 | 226 | 3.8 | 1 | 15 |
| Babe Parilli | BOS | 43 | 215 | 5.0 | 4 | 27 |
| Jacque MacKinnon | SDA | 55 | 186 | 3.4 | 2 | 9 |
| Len Dawson | DAT | 50 | 158 | 3.2 | 3 | 22 |
| Gene Mingo | DEN | 32 | 156 | 4.9 | 4 | 18 |
| Frank Jackson | DAT | 39 | 129 | 3.3 | 3 | 16 |
| Gerry McDougall | SDA | 35 | 115 | 3.3 | 2 | 17 |
| Claude King | BOS | 27 | 106 | 3.9 | 2 | 16 |
| James Stinnette | DEN | 25 | 100 | 4.0 | 4 | 14 |
| Curley Johnson | NYT | 22 | 95 | 4.3 | 2 | 9 |
| Al Frazier | DEN | 22 | 69 | 3.1 | 1 | 16 |
| Johnny Olszewski | DEN | 20 | 65 | 3.3 | 1 | 16 |
| Jack Spikes | DAT | 20 | 63 | 3.2 | 0 | 17 |
| Tom Yewcic | BOS | 8 | 51 | 6.4 | 0 | 15 |
| Willie D. Jones | BUF | 16 | 50 | 3.1 | 1 | 10 |
| Cotton Davidson | OAK | 11 | 42 | 3.8 | 0 | 6 |
| Alan Miller | OAK | 18 | 39 | 2.2 | 1 | 6 |
| Charlie Flowers | NYT | 9 | 34 | 3.8 | 0 | 7 |
| Warren Rabb | BUF | 11 | 31 | 2.8 | 0 | 7 |
| Hez Braxton | SDA | 7 | 29 | 4.1 | 0 | 15 |
| John Hadl | SDA | 18 | 29 | 1.6 | 0 | 7 |
| Johnny Green | NYT | 12 | 28 | 2.3 | 4 | 8 |
| Lee Grosscup | NYT | 2 | 21 | 10.5 | 0 | 15 |
| Jim Tiller | NYT | 7 | 19 | 2.7 | 0 | 15 |
| George Blanda | HOU | 16 | 14 | 0.9 | 1 | 5 |
| Bobby Fowler | NYT | 6 | 14 | 2.3 | 0 | 6 |
| Jack Kemp | BUF | 5 | 13 | 2.6 | 0 | 9 |
| Art Baker | BUF | 6 | 12 | 2.0 | 0 | 7 |
| Hal Lewis | OAK | 4 | 12 | 3.0 | 0 | 7 |
| Al Dorow | BUF | 5 | 11 | 2.2 | 0 | 5 |
| Mel West | NYT | 2 | 11 | 5.5 | 0 | 7 |
| George Shaw | DEN | 3 | 9 | 3.0 | 0 | 9 |
| Don Heinrich | OAK | 4 | 9 | 2.3 | 0 | 5 |
| Chon Gallegos | OAK | 5 | 8 | 1.6 | 1 | 6 |
| Bert Coan | SDA | 6 | 7 | 1.2 | 0 | 6 |
| Frank Tripucka | DEN | 18 | 6 | 0.3 | 2 | 5 |
| Charley Fuller | OAK | 2 | 4 | 2.0 | 0 | 2 |
| Dick Wood | SDA | 6 | 4 | 0.7 | 1 | 5 |
| Carey Henley | BUF | 1 | 1 | 1.0 | 0 | 1 |
| Hunter Enis | OAK | 1 | 1 | 1.0 | 0 | 1 |
| Willie Simpson | OAK | 4 | 0 | 0.0 | 0 | 1 |
| Chris Burford | DAT | 1 | -2 | -2.0 | 0 | -2 |
| Eddie Wilson | DAT | 3 | -3 | -1.0 | 0 | -1 |
| Jerry Robinson | SDA | 2 | -5 | -2.5 | 0 | -1 |