The larger increase in FFM with GH treatment can simply be attributed to an increase in total body water. pictures of steroid abuseWeight lose. In this study as well as the previous one, resistance training supplemented with GH did not further enhance muscle growth or strength. Later, Yarasheski performed a similar study but this time he used experienced weight lifters (3). Skeletal muscle protein synthesis and the whole body rate of protein breakdown were determined using labeled amino acids ([13C]leucine) in 7 young healthy experienced male weight lifters before and at the end of 14 days of subcutaneous GH administration (40 ēg/kg/day). pictures of steroid abuseMuscle gain. GH administration doubled fasting insulin-like growth factor-I levels, but did not increase the rate of muscle protein synthesis or reduce the rate of whole body protein breakdown. These findings confirm what others have found, namely that short-term GH treatment does not increase the rate of muscle protein synthesis or reduce the rate of whole body protein breakdown. You may argue that in the real world, bodybuilders don't use GH alone. pictures of steroid abuseFacts-about-anabolic-steroids. It is generally combined with some form of anabolic steroid. Unfortunately I was unable to find a controlled study looking at the effectiveness of combining androgens and GH in healthy athletes for the purposes of building muscle. There is one study however that looked at the effects of combining both very high doses of androgens (up to 2. 4 mg/kg/day) with or without concomitant GH use (4IU/day) (4). In all cases, using androgens with GH caused a significant decline in IGFBP3 levels. As you know, this dramatically decreases the half life of IGF-1 and thus the biological activity is attenuated. One other very enlightening finding of this study was that on a low calorie diet, it didn't matter how much androgens or GH they were using, both IGF-1 and IGFBP-3 declined significantly. Clearly the effectiveness of any cycle using androgens with or without GH will be greatly diminished by lowering calories, and more importantly total protein. Still, the one question you may have, namely does high dose androgens make GH worth using, was not addresses by this study. The consensus generally is still no. In HIV patients work is being done to determine if GH or androgens will prevent wasting. In these studies Deca Durablolin and other androgens have proven successful at preserving lean mass while GH has not proven to be effective (4). Concerning GH treatment in unhealthy populations, Michael Mooney, a well respected authority on HIV and muscle preservation, has challenged the claims made by at least one manufacturer of a GH product called Serostim. He wrote a letter to them challenging their claims that Serostim or any other brand of GH has true anabolic effects in this population. "I underline that the only study of Serostim that included a critical evaluation of changes in muscle tissue to date showed no change and muscle using MRI (magnetic resonance imaging). All other studies so far have used Bioelectric Impedance Analysis, which measures lean body mass (LBM), but can not accurately measure changes in muscle.