1445 Budapest, Nagyvárad tér 4
P.O.B. 370, Hungary
Phone: (36) 1210-2930/6258 and (36) 3027-47486
Fax: (36) 1210-4412
e-mail: KalHub@pharma.sote.hu; Huba@kalasz.com
Home address: 1144 Budapest, Gvadányi u 44-46, I/46
Phone/Fax: (36) 1220-3580
Date and Place of Birth: March 29, 1941, Miskolc, Hungary
EDUCATION
1987 Doctor of Chemical Science, the Hungarian Academy of Science
(Title of thesis: Modern Chromatographic Methods and their Application in Studies on Drug Metabolism and Isolation of New Endogenous Compounds).
1980 Candidate of Chemical Science, the Hungarian Academy of Science
(Title of thesis: Chromatographic Methods Applied for Isolation of New Endogenous Compounds).
1970 Ph.D., Organic Chemistry, Kossuth Lajos University, Debrecen, Hungary
(Title of thesis: Heptaene Macrolide Antibiotics)
1963 Graduation, B.Sc. in Chemistry, József Attila University, Szeged, Hungary
1958-1963 Undergraduate Studies in Chemistry, József Attila University, Szeged, Hungary
1958 Maturation, Kilián György High School, Miskolc, Hungary
PROFESSIONAL EXPERIENCE AND BACKGROUND
1993-present Scientific Advisor, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
1989-1993 Visiting Professor, Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
1981-1988 Senior Research Associate, Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary
1980-1981 Research Associate, Department of Engineering and Applied Science, Yale University, New Haven, CT, USA
1975-1977 Research Associate, Department of Internal Medicine, Yale University, New Haven, CT, USA
1969-1981 Research Associate, Department of Pharmacology, Semmelweis University of Medicine, Budapest, Hungary
1963-1969 Research Associate, Drug Research Institute, Budapest, Hungary
RESEARCH EXPERIENCE
Bioequivalency studies and stability studies of various drugs. Computer simulation of drug metabolism. Determination of drug effect on striatal dopamine release. Isolation and structural elucidation of various natural products.
Chromatography and related separation methods. HPLC (high-performance liquid chromatography), reversed-phase LC, ion-exchange LC, size-exclusion LC, thin-layer chromatography, forced-flow thin-layer chromatography, affinity chrpomatography, displacement chromatography.
Isolation and characterization of subcellular membrane fractions. Solubilization and purification of receptor proteins. Photoaffinity binding studies. Purification of radiolabelled peptide fragments. Localization of receptor binding sites.
GRANTS
OTKA1884/86, 2,600,000 Ft, Displacement Chromatography
OTKA T014445, 1,200,000 Ft, Displacement FF-TLC
OTKA T023370, 2,100,000 Ft, Metabolism of Endogenous Compounds
OTKA T025142 2,250,000 Ft, Planar Electrochromatography
OTKA T032185 7,200,000 Ft, Displacement Chromatography in the Study
on Metabolism
OTKA T034677 8.000,000Analysis of Formaldehyde Generated by Metabolism
FKFP 0658 4.900.000 Ft, Inhomogeneity of Dopamine D4 Receptors
ETT 553/1997 900 eFt Metabolism of Deprenyl
AWARDS, HONOR
2001 Karoly Than Medal of the Hungarian Chemical Society
1994 Habilitation, Dr. med. habil. (Pharmacology, Budapest)
1988 Adjunct Professor, Institute of Organic Chemistry, József Attila University, Szeged, Hungary
1985 Award of New England Chromatography Council
EDITORIAL BOARDS
2001- LC-GC Europe, Advanstar Publication
2001- Mini-Reviews in Medicinal Chemistry, Bentham Sci. Publ., Regional Editor
1999- Journal of Chromatographic Science, Preston Publication, Co-Editor
1999- Current Medicinal Chemistry, Bentham Sci. Publ.
1998- ACE, Advances in Chromatography and Electrophoresis (Editor-in-Chief)
Publication of the Hungarian Chemical Society, Budapest
1997- Magyar Kémikusok Lapja (Journal of Hungarian Chemists), Publication of the Hungarian Chemical Society, Budapest, Editorial Board Member
1994- Journal of Planar Chromatography, Springer, Editorial Board Member
1988-1993 Journal of Planar Chromatography, Hüthig, Editorial Board Member
1988-1993 Orvosi Magazin (Illustrated Medical Magazine)
PROFESSIONAL MEMBERSHIPS
Hungarian Chemical Society
Hungarian Pharmacological Society
CURRICULUM VITAE
Huba Kalász, Ph.D.
I was born in Miskolc (Hungary) in 1941, attended the elementary and high school in Miskolc.
I spent my University years in Szeged, Faculty of Natural Sciences, University of Szeged (which took the name of József Attila), graduated as a chemist in 1963.
I was working for the Drug Research Institute in Budapest, between 1963 and 1968. My activity was dealing with isolation, identification and structural elucidation of heptaene macrolide antibiotics with antifungal activity. From 1969 I have been working for the Department of Pharmacology, Medical University of Budapest, and I kept the working place. In the meantime, the name of University was changed to Semmelweis University of Medicine, and later on to Semmelweis University. The name of the Department was also changed to Department of Pharmacology and Pharmacotherapy.
I give some lectures on “Chromatography” to the students of the University of Szeged, some course on “General Pharmacology” for the students of Technical University of Budapest, and also the lectures on “Pharmacokinetics”, “Drug Metabolism”, “Drug-Drug Interactions”, “Side Effects of Drugs” and “Oral Toxicology” for students of Faculty of Dentistry, Semmelweis University.
My research activity is concerned on several distinct fields, such as:
1.: Chromatography and related separation methods. HPLC (high-performance liquid chromatography), reversed-phase LC, ion exchange LC, size-exclusion LC, thin-layer chromatography, forced-flow thin-layer chromatography, affinity chromatography, displacement chromatography.
2.: Studies on drug metabolism and identification of metabolites. Bioequivalency studies. Computer simulation of drug metabolism. Determination of drug effect on striatal dopamine release. Isolation and structural elucidation of various natural products.
3.: Isolation and characterization of subcellular membrane fractions. Solubilization and purification of receptor proteins. Photoaffinity binding studies. Purification of radiolabelled peptide fragments. Localization of receptor binding sites.
I have visited conferences all around the world from the USA to Argentina, and from Japan to Spain. I spent 14 months at the Department of Internal Medicine, Yale University, New Haven, CT, USA (working with affinity techniques), 9 months at the Department of Chemical Engineering, Yale University, New Haven, CT, USA (working with HPLC and displacement chromatography) and 4 years at the Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA (working with the localization of binding site of calcium antagonists on the primary structure of calcium channels).
I have published more than 100 papers in various journals, several chapters in books on chromatography and pharmacology. I have been selected into the editorial board of some journals, such as Mini-Reviews in Medicinal Chemistry (Regional-Editor) and Current Medicinal Chemistry, Bentham Publication; Journal of Chromatographic Science, Preston Publication (Co-Editor); ACE, Advances in Chromatography and Electrophoresis (Editor-in-Chief) and Magyar Kémikusok Lapja (Journal of Hungarian Chemists), Publication of the Hungarian Chemical Society, Budapest (Editorial Board Member); Journal of Planar Chromatography, Springer.