While the staff furiously labors over the President's crucial State of the Union speech, Bartlet suddenly demands to include a passage that ambitiously promises a crusade to cure cancer within 10 years while Sam is interviewed for a Vanity Fair profile by a woman (as Lisa, guest star Traylor Howard) whom once was his fiancee. A lovestruck Josh brashly informs a prominent women's rights leader that her budding romance with a Congressman is solely a product of political machinations. Elsewhere, a mischievous C.J. tries to upset Charlie by swiping his top-secret and coded copy of the President's approaching address while pollster Joey Lucas studies the sampled responses to the Chief Executive's speech.