National Library of Medicine: IGM Selected Full Records Screen
Full Citations: 1 to 5 of 5 from 1994-97
TITLE:
Contact pemphigus.
AUTHOR:
Vozza A; Ruocco V; Brenner S; Wolf R
AUTHOR
AFFILIATION:
Department of Dermatology, 2nd University of
Naples, Italy.
SOURCE:
Int J Dermatol 1996 Mar;35(3):199-201
NLM CIT. ID:
96235479
MAIN MESH
SUBJECTS:
*Agriculture
Dermatitis, Occupational/DRUG
THERAPY/*ETIOLOGY/PATHOLOGY
Pemphigus/DRUG THERAPY/*ETIOLOGY/PATHOLOGY
ADDITIONAL
MESH SUBJECTS:
Adult
Case Report
Dermatitis, Contact/DRUG
THERAPY/ETIOLOGY/PATHOLOGY
Fluorescent Antibody Technique, Direct
Hand Dermatoses/DRUG THERAPY/ETIOLOGY/PATHOLOGY
Human
Male
Patch Tests
PUBLICATION
TYPES:
JOURNAL ARTICLE
LANGUAGE:
Eng
TITLE:
Pemphigus and dietary factors. In vitro
acantholysis by allyl compounds of the genus
Allium.
AUTHOR:
Brenner S; Ruocco V; Wolf R; de Angelis E;
Lombardi ML
AUTHOR
AFFILIATION:
Department of Dermatology, Tel-Aviv Sourasky
Medical Center, Israel.
SOURCE:
Dermatology 1995;190(3):197-202
NLM CIT. ID:
95322662
ABSTRACT:
BACKGROUND: Today it is generally accepted that
every drug that possesses an active thiol group
in its molecule is capable of inducing pemphigus
in vivo and provoking acantholysis in vitro. We
therefore suggested that plants, in particular
those belonging to the Allium group, that contain
several active compounds with stable disulfide
and thiol groups in their molecule may cause the
same. OBJECTIVE: To verify this hypothesis by
investigating the in vitro acantholytic effect of
three compounds of garlic. METHODS: Skin samples
from donors were cultured in the presence of
three compounds of garlic (i.e. allylmercaptan,
allylmethylsulfide and allylsulfide) for 3 days.
The skin samples were then processed for
microscopic control for acantholysis. RESULTS:
Results indicate that, indeed, the three garlic
compounds tested are capable of inducing
acantholysis in vitro. Focal and diffuse
acantholysis was observed in the specimens from 4
out of 7 donors cultured in the presence of 6 and
9 mM of each of the allyl compounds for 3 days.
Interestingly, tissues from a DR4+ donor proved
to be more acantholysis prone than others,
showing large blistering due to diffuse
acantholysis, thus indicating that individual
susceptibility plays a crucial role also in
vitro. CONCLUSION: Garlic compounds with stable
disulfide and thiol groups in their molecule are
capable of inducing acantholysis in vitro. These
findings lend further support to the theory that
'harmless' nutritional factors are capable of
inducing acantholysis in vitro and possibly also
in vivo. In view of these findings, it is
suggested that nutritional factors should be
added to the ever-growing list of exogenous
factors capable of inducing pemphigus.
MAIN MESH
SUBJECTS:
Acantholysis/*CHEMICALLY INDUCED/PATHOLOGY
Allyl Compounds/*ADVERSE EFFECTS
Diet/*ADVERSE EFFECTS
*Garlic
Pemphigus/*ETIOLOGY
Skin/*DRUG EFFECTS/PATHOLOGY
ADDITIONAL
MESH SUBJECTS:
Adult
Blister/CHEMICALLY INDUCED/PATHOLOGY
Culture Media
Disulfides/ADVERSE EFFECTS
Female
Human
HLA-DR4 Antigen/ANALYSIS
Middle Age
Plant Oils/ADVERSE EFFECTS
Sulfhydryl Compounds/ADVERSE EFFECTS
Sulfides/ADVERSE EFFECTS
Tissue Culture
PUBLICATION
TYPES:
JOURNAL ARTICLE
LANGUAGE:
Eng
REGISTRY
NUMBERS:
0 (Allyl Compounds)
0 (Culture Media)
0 (Disulfides)
0 (HLA-DR4 Antigen)
0 (Plant Oils)
0 (Sulfhydryl Compounds)
0 (Sulfides)
2179-58-0 (allyl methyl disulfide)
592-88-1 (allyl sulfide)
TITLE:
Contact pemphigus: a subgroup of induced
pemphigus.
AUTHOR:
Brenner S; Wolf R; Ruocco V
AUTHOR
AFFILIATION:
Department of Dermatology, Tel Aviv Sourasky
Medical Center, Ichilov Hospital, Israel.
SOURCE:
Int J Dermatol 1994 Dec;33(12):843-5
NLM CIT. ID:
95189343
MAIN MESH
SUBJECTS:
Dermatitis, Contact/*COMPLICATIONS
Pemphigus/*ETIOLOGY
ADDITIONAL
MESH SUBJECTS:
Human
PUBLICATION
TYPES:
JOURNAL ARTICLE
REVIEW
REVIEW OF REPORTED CASES
LANGUAGE:
Eng
TITLE:
Possible nutritional factors in induced
pemphigus.
AUTHOR:
Brenner S; Wolf R
AUTHOR
AFFILIATION:
Department of Dermatology, Ichilov Hospital, Tel
Aviv, Israel.
SOURCE:
Dermatology 1994;189(4):337-9
NLM CIT. ID:
95178771
ABSTRACT:
Today it is generally accepted that every drug
that possesses an active thiol group in its
molecule is capable of inducing pemphigus. Some
plants, in particular those belonging to the
Allium group, contain several active compounds
with stable disulfide and thiol groups in their
molecule. The Allium group contains many
important vegetables like onion, leek and garlic.
Examples of molecules with an active thiol group
are: CH2 = CH-CH2-S-S-CH2-CH = CH2 (diallyl
disulfide) or CH2 = CH-CH2-S(O)S-CH2-CH = CH2
(allicin). It is suggested that some foods, in
particular vegetables of the Allium group that
contain active thiol groups in their molecule,
could contribute to the induction of pemphigus.
In general, nutritional factors should be added
to the list of exogenous factors that are capable
of inducing pemphigus.
MAIN MESH
SUBJECTS:
*Allium/CHEMISTRY
Pemphigus/*ETIOLOGY
Sulfhydryl Compounds/*ADVERSE EFFECTS/ANALYSIS
Vegetables/*ADVERSE EFFECTS/CHEMISTRY
ADDITIONAL
MESH SUBJECTS:
Disulfides/ADVERSE EFFECTS/ANALYSIS
Human
Nutrition
Sulfinic Acids/ADVERSE EFFECTS/ANALYSIS
PUBLICATION
TYPES:
JOURNAL ARTICLE
REVIEW
REVIEW, TUTORIAL
LANGUAGE:
Eng
REGISTRY
NUMBERS:
0 (Disulfides)
0 (Sulfhydryl Compounds)
0 (Sulfinic Acids)
2179-57-9 (diallyl disulfide)
539-86-6 (allicin)
TITLE:
An active amide group in the molecule of drugs
that induce pemphigus: a casual or causal
relationship?
AUTHOR:
Wolf R; Brenner S
AUTHOR
AFFILIATION:
Department of Dermatology, Tel-Aviv Sourasky
Medical Center, Ichilov Hospital, Israel.
SOURCE:
Dermatology 1994;189(1):1-4
NLM CIT. ID:
94272109
ABSTRACT:
Traditionally, drugs that are capable of inducing
pemphigus are divided into two main groups
according to their chemical structure, in
particular, the existence of a sulfhydryl group
in their molecule. Thus, two groups are formed:
(1) drugs containing a sulfhydryl radical (thiol
drugs or SH drugs) and (2) nonthiol or other
drugs. Much emphasis has been put on the role of
the sulfhydryl group in the pathogenesis of
drug-induced pemphigus. The effects of this group
have been extensively studied, and a logical
paradigm on the mode of its action has been
created. However, no attempt has been made to
search for other biochemical radicals which might
have an influence on the activation/triggering of
this disease. The aim of the present report is to
draw attention to a chemical group common to the
molecule of several drugs that have been
associated with the induction of pemphigus.
Careful analysis of the chemical structure of
nonthiol drugs known to induce pemphigus revealed
that several of them share an active amide group
in their molecule. We believe that this group
might be responsible for the induction of the
disease; thus, a third group of drugs capable of
triggering pemphigus can be formed, namely drugs
containing an active amide group. Several drugs
of this group are discussed.
MAIN MESH
SUBJECTS:
Amides/*ADVERSE EFFECTS/ANALYSIS/CHEMISTRY
Pemphigus/*CHEMICALLY INDUCED
ADDITIONAL
MESH SUBJECTS:
Cephalosporins/ADVERSE EFFECTS
Enalapril/ADVERSE EFFECTS
Human
Penicillins/ADVERSE EFFECTS
Sulfhydryl Compounds/ANALYSIS
PUBLICATION
TYPES:
JOURNAL ARTICLE
REVIEW
REVIEW, TUTORIAL
LANGUAGE:
Eng
REGISTRY
NUMBERS:
0 (Amides)
0 (Cephalosporins)
0 (Penicillins)
0 (Sulfhydryl Compounds)
75847-73-3 (Enalapril)
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