Curriculum Vitae and Scientific References for

Jens Perregaard


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CURRICULUM  VITAE

Name:  JENS KRISTIAN PERREGAARD, PhD
Phone:  (+45)47536656 (Denmark)     (+34)966718517 (Spain)
e-mail:                         perregaard.geo@yahoo.com
Webpage:                    http://www.oocities.com/yosemite/8172
Date of birth:               23.March 1949
Marial Status:    Married since 1970; A son Michael born 4.12.1971
Latest Position:                      Head of Department of Medicinal Chemistry
H. Lundbeck A/S, Ottiliavej 9
DK-2500 Valby, Denmark
Education: Cand Scient 1975 (M.Sc.), specialized in Organic Synthetic Chemistry. University of Aarhus
Lic. Scient. 1977 (Ph.D.). University of Aarhus
Thesis: HMPA as reagent and solvent in organic chemistry I+II
Employment:                   1975: Cheminova A/S
1975-1977: University of Aarhus, Chemical Institute
1975-1977: Teaching at Diakonhøjskolen and Aarhus Teknikum
1977-1979: Organic Geochemistry, The Geological Survey of Greenland
1979-1998: Medicinal Chemistry Research, H. Lundbeck A/S
1998-  :     Retired
Training:                  1977:  Organic Geochemistry, University of Newcastle
1977:  Organic Geochemistry, Kernforschungsanlage Julich
1977:  Organic Geochemistry, IFP/Paris and Elf-Aquitaine/Pau
1979:  Wiswesser Line Notation, Paris
1981:  NMR Nottingham
1985:  NMR, Fallanden
1986:  NMR, Upsala
1979-1998: training in Medicinal Chemistry and Management
Publications:                 39 scientific publications
Patents:                         30 main patent applications and patents
Posters:       20 poster presentations
Reviewer:        J.Med.Chem.; Eur.J.Med.Chem.; Current Drugs Ltd.
Censor:                      Danish Pharmaceutical High School (PhD); Laborantskolen for Hovedstadsområdet (Technicians)
Adresses   :  Bautahøjvej 44, 3630 Jægerspris, Denmark
c/Picos de Europa 11, Ciudad Quesada, 03170 Rojales (Alicante), Spain


                                                    

 




 


PUBLICATIONS

 

1.      E.B.Pedersen, J.Perregaard, and S.-O. Lawesson (1973)
         Studies on Organophosphorus Compounds - IV. HMPA as Precursor for Dimethylamine
         in Nucleophilic Aromatic Substitution Reactions.
        Tetrahedron, 29, 4211.

2.     J.Perregaard, E.B.Pedersen, and S.-O. Lawesson (1974)
        Studies on Organophosphorus Compounds - VII. Synthesis of Phenolic Esters of N,N-
        Dimethylphosphoric Acid Amidates and N,N-Dimethylphosphoramidochloridic Acid from
        HMPA.
        Rec. Trav. Chim., Pays-Bas, 93, 252.

3.     J.Perregaard, I.Thomsen, and S.-O. Lawesson (1975)
        Studies on Organophosphorus Compounds - XI. Oxidation of Aromatic Compounds with
        Sulphur in Hexamethylphosphoric Triamide (HMPA). A New Method for Preparation of
        N,N-Dimethylthiocarboxamides.
        Acta Chem.Scand. , B29, 538.

4.     J.Perregaard, I.Thomsen, and S.-O. Lawesson (1975)
        Studies on Organophosphorus Compounds - XII. About Elemental Sulphur as a Reducing Agent
         in Hexamethylphosphoric Triamide (HMPA).
        Acta Chem.Scand. , B29, 599.

5.     J.Perregaard and S.-O. Lawesson (1975)
        Studies on Organophosphorus Compounds - XIII. About Conversion of Carboxylic Esters into
         N,N-Dimethylthiocarboxamides. Synthesis of 2-Phenylbenzothiazole.
        Acta Chem.Scand. , B29, 604.

6.     J.Perregaard and S.-O. Lawesson (1977)
        Studies on Organophosphorus Compounds - XV. Synthesis of 2-Arylbenzothiazoles and 2-(a-
        Pyridyl)naphthothiazoles by Sulphur Oxidation in Hexamethylphosphoric Triamide (HMPA).
           13C NMR Studies.
        Acta Chem.Scand. , B31, 203.

7.     J.Perregaard, I.Thomsen, and S.-O. Lawesson (1977) 
        Studies on Organophosphorus Compounds - XVI. On O,O-Dialkyl Dithiophosphoric Acids and
        N,N,N´,N´-Tetramethylthiophosphoric Diamide as Thiation Agents : Conversion of Carboxamide
        into Thiocarboxamides, Alkyl Dithiocarboxylates, or Nitriles.
        Bull.Soc.Chim. Belg. , 86, 321.

8.     J.Perregaard, B.S. Pedersen, and S.-O. Lawesson (1977)
        Studies on Organophosphorus Compounds - XVII. About O,O-Diethyl Dithiophosphoric Acid as
        Thiation and Alkylation Agent. A New Route to Dithiocarboxylic Esters and Ethylthioheterocycles.
        Acta Chem.Scand. , B31, 460.

9.     J.Perregaard, S.Scheibye, H.J.Meyer, I.Thomsen, and S.-O. Lawesson (1977)
        Studies on Organophosphorus Compounds - XVIII. Oxidation of Tertiary Alicyclic Amines with
        Elemental Sulphur in Hexamethylphosphoric Triamide (HMPA). Oxidative Rearrangements of
        Hexahydroazepines and Octahydroazocines to Bis(3-pyrroll)polysulphides.
        Bull.Soc.Chim. Belg. , 86, 679.

10.   J. Perregaard (1977)
        HMPA som reagens og opløsningsmiddel i organisk kemi, I+ II.
        Ph.D.Thesis, Chemical Institute, University of Aarhus.

11.   J.Perregaard (1978)
        Establishment of an Organic Geochemical Laboratory in GGU.
        Rapp.Grønlands Geol.Unders., 90, 150.

12.   J.Perregaard and E.J.Schiener (1979)
        Thermal Alteration of Sedimentary Organic Matter by a Basalt Intrusive (Kimmeridgian Shales,
        Milne Land, East Greenland).
        Chem.Geol., 26, 331.

13.   J.Perregaard and E.J.Schiener (1979)
        Organic Geochemical and Microscopical Studies of Sedimentary Organic Matter, Central West
        Greenland.
         Rapp.Grønlands Geol.Unders., 95, 55.

14.    J.Perregaard (1979)
        Organic Geochemistry of Sedimentary Organic Matter from Greenland. A Petroleum Source Rock
        Evaluation.
        The Geological Survey of Greenland 110 pp.

15.   E.J.Schiener and J.Perregaard (1981)
        Thermal Maturation of Organic Matter by a Thick Basaltic Sill in Upper Cretaceous Shales, Svartenhuk
        Halvø, Central West Greenland.
        Rapp.Grønlands Geol.Unders., 102, 1-16

16.   N.Lassen and J.Perregaard (1983)
        Synthesis and NMR studies of Z- and E-Isomers of 10-Oxo and 10-Hydroxy Derivatives of Amitriptyline
        and Nortriptyline.
        Acta Chem.Scand. , B37, 335-340.

17.   J.Arnt, J.Hyttel and J.Perregaard (1987)
        Dopamine D-1 Receptor Agonists Combined with the Selective D-2 Agonist Quinpirole Facilitate the
        Expression of Oral Stereotyped Behaviour in Rats.
        Eur.J.Pharmacol., 132(2), 137-145.

18.   J.Arnt and J.Perregaard (1987)
        Synergistic Interaction Between Dopamine D-1 and D-2 Receptor Agonists: Circling Behaviour of Rats
        with Hemitransection.
        Eur.J.Pharmacol., 143(1), 45-53.

19.   T.Skarsfeldt and J.Perregaard (1990)
        Sertindole, a New Neuroleptic with Extreme Selectivity in A10 Versus A9 Dopamine Neurones in the
        Rat.
       Eur.J.Pharmacol., 182, 613-614.

20.   C.Sanchez, J.Arnt, N.Dragsted, J.Hyttel, H.L.Lembøl, E.Meier, J.Perregaard, and T. Skarsfeldt (1991)
        Neurochemical and in vivo Pharmacological Profile of Sertindole, a Limbic-Selective Neuroleptic
        Compound.
        Drug Dev.Res., 22(3), 239-250

21.   K.Gundertofte, J.Perregaard, K.P.Bøgesø, J.Hyttel, and J.Arnt (1991)
        QSAR Study on the Neuroleptic and 5-HT2-antagonistic activities in a series of phenylindoles.
        In QSAR : Rational Approaches to the Design of Bioactive Compounds; C.Silipo and A.Vittoria, Eds;
        Elsevier: Amsterdam, 1991; pp 465-468

22.   T.Skarsfeldt, J.Arnt, J.Hyttel, E.Meier, J.Perregaard, C.Sánchez (1991)
        Pharmacological Evaluation of Sertindole: A New Atypical Neuroleptic.
        Schizophrenia Research, 4, 326

23.   J.Perregaard, J.Arnt, K.P.Bøgesø, J.Hyttel, and C.Sanchéz (1992)
        Noncataleptogenic, Centrally Acting Dopamine D-2 and serotonin 5-HT2 antagonists within a series of
        3-substituted 1-(4-fluorophenyl)-1H-indoles
        J.Med.Chem. 35 (6), 1092-1101

24.   J.Hyttel, K.P.Bøgesø, J.Perregaard, and C.Sánchez (1992)
        The Pharmacological Effect of Citalopram Resides in the (S)-(+)-Enantiomer.
        J.Neural.Transm.: Gen.Sect. 88(2), 157-160

25.   J.Perregaard, K.Andersen, J.Hyttel, and C.Sánchez (1992)
        Selective, Centrally Acting Serotonin 5-HT2 Antagonists. 1: 2- and 6-Substituted 1-Phenyl-3-
        (4-piperidinyl)-1H-indoles.
        J.Med.Chem. 35, 4813-4822

26.   K.Andersen, J.Perregaard, J.Arnt, J.B.Nielsen, and M.Begtrup (1992)
        Selective, Centrally Acting Serotonin 5-HT2 Antagonists. 2: Substituted 3-(4-fluorophenyl)-
        1H-indoles.
        J.Med.Chem. 35, 4823-4831

27.   J.Perregaard, J.Arnt, and C.Sánchez (1993)
        Recent Developments in Anxiolytics.
        Current Drugs ,Current Opinion in Therapeutic Patents, January 1993, 101-128p

28.   K.Andersen, T.Liljefors, K.Gundertofte, J.Perregaard, and K.P.Bøgesø (1994)
        Development of a Receptor-Interaction Model for Serotonin 5-HT2 Receptor Antagonists.
        Predicting Selectivity with Respect to Dopamine D2 Receptors.
        J.Med.Chem. 37, 950-962

29.   K.P. Bøgesø, K. Andersen, J. Arnt, K. Frederiksen, J. Hyttel, J. Perregaard, and
        T. Skarsfeldt (1995)
        Design of Atypical Antipsychotic Drugs ?
        Proceedings of the Alfred Benzon Symposium, 38, Schizophrenia, An Integrated View,
        p 361-374, Eds. R.Fog, J. Gerlach, R. Hemmingsen, Munksgaard, Copenhagen 1995.

30.   J. Perregaard, E. K. Moltzen, E. Meier, and C. Sánchez (1995)
        Sigma Ligands with Subnanomolar Affinity and Preference for the s2 Binding Site. Part 1.
        3-(w-Aminoalkyl)-1H-indoles.
        J.Med.Chem. 38, 1998-2008.

31.   E. K. Moltzen, J. Perregaard, E. Meier (1995)
        Sigma Ligands with Subnanomolar Affinity and Preference for the s2 Binding Site. Part 2.
        Spiro-joined Benzofuran, Isobenzofuran, and Benzopyran Piperidines.
        J.Med.Chem. 38, 2009-2017.

32.   J. Perregaard, F. Højelse, and F.W. Andersen (1995)
        Eco-toxicological, Toxicological, and Physical-Chemical Investigations of Potassium 2,5-
        Dichlorobenzoate and Potassium N-(4-Fluorophenyl)glyucinate.
        Dansk Kemi 3, 14-15. Chem.Abstr. 1997, 126, 26646

33.   K. Sakamoto, Y. Nakamura, S. Aikoh, T.Baba, J. Perregaard, H. Pedersen, E.K. Moltzen,
        D. J. Mulford, and T. Yamaguchi (1995)
        Metabolism of Sertindole : Identification of the Metabolites in the Rat and Dog, and other
        Species Comparison of Liver Microsomal Metabolism.
        Xenobiotica 25 (12), 1327-1343.

34.   K.Andersen, T.Liljefors, J.Hyttel, and J.Perregaard (1996)
        Serotonin 5-HT2 Receptor, Dopamine D2 Receptor and a1 Adrenoceptor Antagonists.
        Conformationally Flexible Analogues of the Atypical Antipsychotic Sertindole.
        J.Med.Chem. 39, 3723-3738.

35.   C.Sánchez, J.Arnt, B.Costall, M.E.Kelly, E.Meier, R.J.Naylor, and J. Perregaard (1997)
        The Selective s2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents.
        J.Pharmacol. & Exp. Ther. 283 (3), 1323-1332

36.    E.Falch, J.Perregaard, B.Frølund, B.Søkilde, A.Buur, L.M.Hansen, K.Frydenvang, L.Brehm,
        T.Bolvig, O.M.Larsson, C.Sanchez, A.Schousboe, and P.Krogsgaard-Larsen (1999)
        Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry and Phar-
        macology of the Enantiomers of 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole
       ( Exo-THPO) and analogues.
        J.Med:Chem (published)

37.    T.Balle, J.Perregaard, S.Larsen, T.Ramirez, K.K.Søby, T.Liljefors, and K. Andersen (2002)
        Synthesis and Structure-Affinity Relationship Investigations of 5-Aminomethyl and 5-Carbamoyl
        Analogues of the Antipsychotic Sertindole. A New Class of Selective
a1 Adrenoceptor Antagonists
        (To be submitted)

38.    T.Balle, J.Perregaard, T.Ramirez, S.Larsen, K.K.Søby, T.Liljefors, and K.Andersen (2002)
        Synthesis and Structure-Affinity Relationship Investigations of 5-Heteroaryl Substituted Analogues
        of the Antipsychotic Sertindole. A New Class of Selective
a1 Adrenoceptor Antagonists
        (To be submitted)

39.    T.Balle, C.Halldin,Y.-W.Chou,K.Andersen, J.Perregaard, L.Badolo and L.Farde (2002)
        Carbon-11 Labelling of New Centrally Active
a1 Adrenoceptor Antagonists Derived from the
        Antipsychotic Sertindole. PET Examinations in Cynomolgus Monkey.
        (To be submitted)

 

PATENTS

1.     Jens Kristian Perregaard;
        3-Substituted 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridines and their pharmaceutical compositions.
        GB 80-38139, 1980; Chem.Abstr. 1982,97, 182394q

2.     Jens Kristian Perregaard;
        2-acyl-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ones, their use as medicines and their
        pharmaceutical compositions.
        GB 80-38140,1980;Chem.Abstr. 1982, 97, 182395r

3.     Jens Kristian Perregaard;
        Phenylindene derivatives, acid addition salts thereof, and methods of preparation.
        Jpn.Kokai Tokkyo Koho JP 5989661, 1984; Chem.Abstr. 1985,102, 24484m

4.     Jens Kristian Perregaard;
        Indole derivatives and their antipsychotic activity.
        US Patent No. 4,710,500, 1987; Chem.Abstr. 1986, 106, 67110m

5.     Jens Kristian Perregaard;
        Process for the preparation of haloperidol acetate and pharmaceutical composition
        thereof.
        European Patent Application No. 87-307799, 1987; Chem.Abstr. 1988,109, 37741n

6.     Klaus Peter Bøgesø, Jens Kristian Perregaard;
        Preparation and formulation of 3-aminomethyl derivatives of indan, indoline, dihydro-
        benzofuran and dihydrobenzothiophene for treatment of central nervous system disorders.
        European Patent Application No. 88-301073, 1988; Chem.Abstr. 1988,110, 75302y

7.     Klaus Peter Bøgesø, Jens Kristian Perregaard;
        Pharmaceutically useful (+)-1-(3-dimethylaminopropyl)-1-(4´-fluorophenyl)-1,3-dihydro-
        isobenzofuran-5-carbonitrile and non-toxic acid addition salts thereof.
        US Patent No. 4,943,590, 1991; Chem.Abstr. 1989, 113, 78150v

8.     Jens Kristian Perregaard, John W. Stenberg;
        Preparation of piperazinyl derivatives, and their use as serotonergic agonists in the treatment
        of central nervous system disorders
        US Patent No. 5,002,948, 1991; Chem.Abstr. 1990, 114, 17582m

9.     Jens Kristian Perregaard, Torben Skarsfeldt;
        Pharmaceutical compositions containing and use of Sertindole for the treatment of schizophrenia
        European Patent Application No. 90-610022, 1990; Chem.Abstr. 1990,114, 221411j

10.   Jens Kristian Perregaard, Henrik Pedersen, Kim Andersen, Klaus Peter Bøgesø;
        Preparation of 1-aryl-3-piperidylindoles as CNS agents
        European Patent Application No. 91-610055, 1991;Chem.Abstr. 1992, 116, 151564b

11.   Jens Kristian Perregaard, Brenda Costall;
        Preparation of 3-(4-piperidinyl)-N-arylindoles as anxiolytics
        Application No. WO 9200070, 1992;Chem.Abstr. 1992, 116, 194150f

12.   Jens Kristian Perregaard, Kim Andersen;
        Preparation of 3-arylindole and 3-arylindazole derivatives as 5-HT2 antagonists
        European Patent Application No. 91-610058, 1991;Chem.Abstr. 1992, 116, 235431u

13.   Jens Kristian Perregaard, Henrik Pedersen;
        Preparation of sertindole prodrugs
        Application No. WO 9206089, 1992;Chem.Abstr. 1992, 117, 234011r

14.   Jens Kristian Perregaard, Brenda Costall;
        1-Aryl-3-(4-piperidyl)indole derivatives for treatment of addiction to drugs and substances
        of abuse
        Application No. WO 9215302, 1992;Chem.Abstr. 1992, 117, 247029c

15.   Jens Kristian Perregaard, Brenda Costall;
        Arylpiperidylindole derivatives for treatment of cognitive disorders
        Application No. WO 9215303, 1992; Chem.Abstr.. 1992, 118, 825c

16.   Jens Kristian Perregaard, Nils Dragsted;
        Treatment of hypertension and peripheral vascular diseases with 1-aryl-3-(4-piperidyl)indoles.
        Application No. WO 9215301, 1992; Chem.Abstr. 1992, 118, 27472x

17.   Ejner K. Moltzen, Jens Kristian Perregaard;
        4-(Phenylalkyl)piperidines, e.g. spiro-1(3H),4´-piperidine] derivatives, and their use for the
        treatment of mental disorders.
        European Patent Application No. 92-610044, 1992; Chem.Abstr. 1993,119, 117118m

18.   Jens Kristian Perregaard, Torben Skarsfeldt;
        Use of arylindole derivatives for the treatment of psychoses.
        Application No. WO 9312790, 1993; Chem.Abstr. 1993, 119, 152106

19.   Jens Kristian Perregaard, John W. Stenberg, Ejner K. Moltzen
        Preparation and formulation of dimeric piperidine, tetrahydropyridine, and piperazine derivatives
        as nervous system agents.
        Application no. WO 9325527, 1993; Chem.Abstr. 1994, 120 , 270124a

20.   Jens Kristian Perregaard
        Preparation and formulation of aminomethylindans, -benzofurans and benzothiophenes as 5-HT1A
        receptor agonists
        Application no. WO 9413620 , 1994; Chem.Abstr. 1994, 121, 205201

21.   Ejner K. Moltzen, Jens Kristian Perregaard, Henrik Pedersen
        New fused benzo derivatives are 5-HT1a receptor ligands - useful for treating anxiety, depression,
        psychosis, impulse control disorders, alcohol abuse etc.
        Application no. WO 9413659, 1994; Chem. Abstr. 1994, 122, 290887

22.   Jens Kristian Perregaard, Ejner K. Moltzen, Kim Andersen, Henrik Pedersen., Klaus P. Bøgesø,
        Andre Pernet, Barbara Bopp, Darcy Mulford, Kiyoshi Sakamoto.
        Preparation of chloro(fluorophenyl)[[(dihydroimidazolonyl)ethyl]piperidinyl]indole 5-HT2 receptor
        antagonists.
        Application no. WO 9512591, 1995; Chem. Abstr. 1995, 123, 228185

23.   Kim Andersen, Jens Kristian Perregaard
        Preparation of 1-arylindole-3-alkanamines and analogs as serotoninergic S2-antagonists.
        Application no. WO 9516684, 1995; Chem. Abstr. 1995, 123, 313758

24.   Jens Kristian Perregaard, John W. Stenberg, Bitten Hansen
        Preparation of N-(indanylmethyl)piperidines and -piperazines and analogs as 5- HT1A and/or
        5-HT2A ligands.
        Application no. WO 9533721, 1995; Chem. Abstr. 1996, 124, 232261

25.   Jens Kristian Perregaard and Ejner K. Moltzen.
        Serotonin 5-HT1A and dopamine D2 receptor ligands.
        Application no. WO 9533729, 1995; Chem. Abstr. 1996, 124, 261070.

26.   E. Falch, J.K. Perregaard, Sibylle Moltzen Lens, A. Schousboe, P. Krogsgaard-Larsen,
        B. Frølund, S.L. Moltzen.
        Preparation of 4-aminotetrahydrobenzisoxazole and -isothiazole GABA-uptake inhibitors
        Application no. WO 9626929, 1996; Chem.Abstr. 1996, 125, 275857

27.   Jens Kristian Perregaard, Benny Bang-Andersen, Henrik Pedersen, Ivan Mikkelsen and Robert
        Dancer.
        Preparation of Indane and Dihydroindole Derivatives as Dopamine D4 Receptor, 5-HT Receptor,
        and 5-HT transporter Ligands.
        Application no. WO 9828293, 1997; Chem.Abstr. 1998, --, 479524

28.   Jens Kristian Perregaard, Ivan Mikkelsen, and , Henrik Pedersen.
        Preparation of Indane or Dihydroindole Derivatives as Psychotropics.
        Application no. WO 9828290, 1997; Chem.Abstr. 1998, --, 479521

29.   Ejner K. Moltzen and Jens Kristian Perregaard
        Indole and 2,3-dihydroindole derivatives, their preparation and use (1997)
        (application submitted)

30.   Jens Kristian Perregaard and Kim Andersen
        5-Heteroaryl substituted indoles as alfa1 antagonists (1998)
        (application submitted)

 

POSTERS

1.     H.Nielsen, J.Perregaard (1983)
        Identification of Tefludazine Metabolites in biological material by 1H-NMR

2.     J.Perregaard, K.P.Bøgesø, J.Arnt, A.V.Christensen, J,Hyttel, J.J.Larsen (1985)
        Potent neuroleptic activity in a series of phenylindenes, -indoles, and -indazoles
        Presented at 3rd SCI-RSC Medicinal Chemistry Symposium, 15-18 Sept. 1985, Cambridge, England

3.     J.Perregaard, T.Skarsfeldt, J.Arnt, J.Hyttel, C.Sanchez, K.P.Bøgesø (1990)
        Sertindole, a new atypical neuroleptic.
        Presented at XIth International Symposium on Medicinal Chemistry, 1990, Jerusalem, Israel

4.     T.Skarsfeldt, J.Arnt, J.Hyttel, E.Meier, J.Perregaard, C.Sánchez (1990)
        Pharmacological profile of sertindole: A new atypical Neuroleptic.
        Presented at XVII CINP, 1990, Kyoto, Japan

5.     J.Arnt, T.skarsfeldt, J.Hyttel, J.Perregaard, C.Sánchez (1990)
        Sertindole, a new atypical neuroleptic.
        Soc.Neurosci.Abstract , 1990, 16,248, Abstr.109.9

6.     T.Skarsfeldt, J.Arnt, J.Hyttel, E.Meier, J.Perregaard, C.Sánchez (1991)
        Pharmacological Evaluation of Sertindole : A new Atypical Neuroleptic.
        Presented at International Congress on Schizophrenia Research, Tucson, Arizona, April 21-25 1991

7.     J.Perregaard, J.Arnt, J.Hyttel (1991)
        3-Indolylbutyl- and 3-(2,3-dihydroindolyl)butylpiperazines as partial 5-HT1A agonists.
        Presented at 8th Camerino-Noordwijkerhout Symposium, 8-12 sept.1991, Camerino, Italy

8.     K.Andersen, J.Perregaard, J.Arnt, J.Hyttel, C.Sánchez (1992)
        Selective, centrally acting serotonin 5-HT2 antagonists within series of substituted phenylindoles.
        Presented at 204th ACS National Meeting, Washington DC, August 23-28 1992

9.     J.Perregaard, K.Andersen, J.Arnt, J.Hyttel, C.Sánchez (1992)
        Selective, centrally acting serotonin 5-HT2 antagonists within series of substituted phenylindoles.
        Presented at XIIth International Symp. on Medicinal Chemistry, Basel sept.13-17 1992.

10.   E.K.Moltzen, J.Perregaard, E.Meier, C.Sánchez, J.Arnt, J.B.Nielsen (1992)
        Spiro-cyclic isobenzofuran derivatives: a new class of high-affinity sigma ligands with potent anxiolytic
        activities.
        Presented at XIIth International Symp. on Medicinal Chemistry, Basel sept.13-17 1992.

11.   K.Andersen, T.Liljefors, K.Gundertofte, J.Perregaard, K.P.Bøgesø (1993)
        Development of a Receptor-Interaction Model for Serotonin 5-HT2 Receptor Antagonists.
        Presented at 9th Noordwijkerhout-Camerino Symposium, Noordwijkerhout 23- 27 May 1993.

12.   J.Perregaard, E.K.Moltzen, E.Meier, C.Sánchez and J.Hyttel (1993)
        4-Phenylpiperidines and 4-spiropiperidines with sub-nanomolar affinity for sigma binding sites and
        with potent anxiolytic activity.
        Presented at 23 rd Soc.Neurosci., Washington DC, November 7-12 1993. Abstr. 19, 763.16.

13.   J.Perregaard, T. Skarsfeldt, K.Andersen, K.P.Bøgesø, K.Frederiksen (1994)
        Structural Analogues of the Antipsychotic Sertindole. Studies on the Firing of Dopamine Neurons
        in A10 and A9 Rat Brain Areas after Chronic Administration.
        Presented at 24th Soc.Neurosci., Miami, November 13-18 1994. Abstr. 20, 726.11

14.   E.K.Moltzen, J.Perregaard, E.Meier (1994)
        Spiro-cyclic Piperidine Derivatives : Structure-Affinity Studies of High-Affinity Sigma Ligands Related
        to Lu 28-179.
        Presented at XIIIth International Symp. on Medicinal Chemistry, Paris September 19-23 1994.

15.   C.Sánchez, J.Arnt , J.Perregaard (1994)
        Lu 28-179 - A Selective Sigma Ligand with Potent Anxiolytic Effects.
        Presented at 24th Soc.Neurosci., Miami, November 13-18 1994. Abstr. 20, 164.16

16.   K.Andersen, J.Perregaard, T.Liljefors, J.Hyttel (1995)
        Serotonin 5-HT2A, Dopamine D2 and Noradreline a1 Antagonists - Analogues of the Atypical
        Antipsychotic Sertindole.
        Presented at the 210th ACS Meeting, Chicago, August 1995. Abstracts of Papers American
        Chemical Society 210 (1-2), MEDI 130.

17.   J.Perregaard, J.Arnt, C.Sanchez (1996)
        High-Affinity Serotonin 5-HT1A Ligands Within a Series of 6-Substituted 1- Indanmethylamines.
        Presented at 26th Soc.Neurosci., Washington, November 16-21 1996, Abstr.

18.   E.K. Moltzen, J.Perregaard, J.Arnt (1996)
        Structure-Activity Relationships of a Series of 5-HT1A Agonists / D2 Antagonists : Potential
        Antipsychotics.
        Presented at 26th Soc.Neurosci., Washington, November 16-21 1996, Abstr.

19.   Petersen K; Olesen O F; Perregaard J K ; Mikkelsen J D (1997)
        Synuclein-NACP mRNA expression in rat hippocampus and cerebral cortex during development
        Presented at 27th Annual Meeting of the Society for Neuroscience, Part 1, New Orleans, Louisiana,
        USA, October 25-30, 1997. Abstr. 23 (1-2). 1997. 267.

20.   Bang-Andersen B; Pedersen, H; Perregaard, J (1998)
        Dopamine D4 Ligands with action on 5-HT Receptors and/or 5-HT-Uptake Sites within a series of
        Indanes and Indolines.
        Presented at the 216th American Chemical Society National Meeting, Boston, USA, 23-27 August 1998.

 


Updated 02-05-2002  Jens Perregaard

 

 

 

 

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