| Name | Guardianship | |
|---|---|---|
| Abby Owens | Keeper of her mysterious past | |
| Al | Keeper of the day she jumped Jax on the couch | |
| Alexisfan | ||
| Ali | Keeper of her sharp mind | |
| Alice | Keeper of her mysterious side | |
| Amie Martin | Keeper of the truth defined by Alexis | |
| Amy | Keeper of her law degree | |
| Amy | Keeper of her love and devotion for Stefan and Nik | |
| Amy | Keeper of her secrets | |
| Annmarie | Keeper of Ned and Alexis' first child | |
| Ashley | ||
| Ashley | Keeper of her fights with Luke | |
| Becky | ||
| Big Easy | Keeper of her rapier wit | |
| Bridget | Keeper of her car keys | |
| BJTimoria | ||
| Caraugh | ||
| Cee (President; co-founder) | Keeper of her cool clothes | |
| Cheryl | Keeper of her undeniable attraction to Ned | |
| Chewbo | Keeper of her witty tongue | |
| Christina | Keeper of the day Ned and Alexis make love | |
| C.J. | Keeper of her cunningness in dating rituals | |
| Corbygirl | Keeper of her enigmatic henchman, Leo | |
| Cynthia (Vice President) | Keeper of her chemistry with Luke | |
| Dima | Keeper of her Julia Wainwright spirit | |
| Donna | ||
| Eleanor | Keeper of her comebacks | |
| Erica | Keeper of her need for Ned | |
| Heather | Keeper of her role as head of Stefan's Clean Up Committee | |
| Heather | Keeper of her longing to be with Ned | |
| Heather | ||
| Heather Nabers | ||
| Iwa | Keeper of her love for Nikolas | |
| Jaberndt | ||
| JamGH24 | ||
| Jay | ||
| Jen (Co-founder) | Keeper of her family values | |
| Jen | Keeper of her relationship with (??????) | |
| Jennifer | ||
| Jennifer Kaiser | Keeper of her natural beauty and smile | |
| Jessica | Keeper of her commitment to her family | |
| Jessica Hall | Keeper of her thankless tasks | |
| Jessica | ||
| Jessica | Keeper of her hatred for Helena | |
| Jill | ||
| Jill | Keeper of her spunk and her marriage to Jax | |
| Jillsara | Keeper of her intelligence | |
| Jill Suzanne | Keeper of her and Ned's love for each other | |
| Joe (Birthday Officer) | Keeper of her medallion | |
| Juanita | Keeper of her briefcase | |
| Karen | Keeper of her mother's instinct | |
| Kate | ||
| Katie | Keeper of her amorous feelings for Ned Keeper of her protective feelings for Stefan and Nikolas | |
| Kayla Chase | Keeper of the engagement ring Ned gives her (hopefully) | |
| Kcb264 | Keeper of her gun | |
| Keira | Keeper of her sanity and her intelligence | |
| Keturah | Keeper of the flowered sarongs | |
| Kimberly | Keeper of her classy beauty | |
| Kim | Keeper of her evilness | |
| Kristina | Keeper Of the passionate kiss she shared with Ned | |
| Kristine | ||
| Kristen | Keeper of her possible feelings for Ned | |
| Kristy | Keeper of her safety from Helena | |
| Laura (Robinfan) | Keeper of her love for Nik | |
| Laura | Keeper of Alexis and Ned's First Night Together | |
| Leigh | Keeper of the dance she shared with Ned after the Nurses' Ball | |
| Leah | Keeper of her classiness and romance with Ned | |
| Leah | Keeper of her right hook that Katherine will soon be the recipient of | |
| Linda | Keeper of her willfullness | |
| Linda Nordman | ||
| Lisa | Keeper of the Ned and Alexis Gatekeeper Society | |
| Lisa | Keeper of Natasha, Future Cassadine Queen | |
| Lisa | ||
| Liz | Keeper of the attraction between Ned and Alexis | |
| LoisGWH | ||
| Lori | Keeper of her computer skills | |
| Lori | ||
| Lorraine | Keeper of her cousin Nikolas | |
| MagicGH612 | ||
| Maggie | Keeper of her unique friendship with Luke | |
| Maile | ||
| Marjorie | Keeper of her intrique | |
| Marissa | Keeper of her love for Stefan, Nik, and Ned | |
| Mary | Keeper of the day she and Luke team up | |
| Melanie | Keeper of her relationship with Nik | |
| Mia | ||
| Michelle | Keeper of the sly smile she flashes at Ned | |
| Michelle | Keeper of her sound machine | |
| Mike | Keeper of her flirtatious bickering with Luke | |
| MitziE | Keeper of her wit, wisdom, and loyalty | |
| Natalie | Keeper of her lies | |
| Natasha Roberts | Keeper of the Sweet Revenge Alexis will have on Stefan for Kicking Her Out of the Family | |
| Nichole | Keeper of her surprises for Ned | |
| Nicole | Keeper of her glasses | |
| Nicole | Keeper of her continued devotion to Nikolas even after her estrangement from the Cassadines | |
| Noona | Keeper of her and Nik's high five | |
| Ocean | Keeper of her keys to the Cassadine Gates; Keeper of her chemistry with Ned | |
| Paula | Keeper of her intense chemistry with Ned | |
| Rina | ||
| Riz | Keeper of her banter with Luke | |
| Roxy | ||
| Samantha | Keeper of her suite at the Port Charles Hotel | |
| Sandra | Keeper of the day she hit Luke over the head with her gun | |
| Sarah | Keeper of her bar exam | |
| Shannon (pingu) | Keeper of her sharp wit | |
| Shari | Keeper of her relationship with Ned | |
| Shari | Keeper of her loyalty to her family | |
| Sierra | Keeper of her intense hatred for Dorman | |
| Sip | Keeper of her heart, which melts when encountering Ned's dimples; keeper of the hand that was kissed in the airport | |
| Skye | Keeper of her kiss with Ned | |
| SoapisMe | Keeper of banjos in the Cassadine closet of secrets | |
| Srr14 | Keeper of her personal and social life | |
| Tallen2 | ||
| Terri | Keeper of her secrets (2) | |
| Trixie | Keeper of her witty comments | |
| TwistyFate | ||
| Vicky | ||