A few Considerations

Size

For small living things, surface area considerations are important, relatively speaking. For instance, keeping the heat in (insulation) and nourishment (generating internal heat) tend to be proportionally more important for smaller animals. Smaller animals tend to experience more air resistance; larger animals tend to fall faster.

Volume-related issues tend to predouminate for larger living things:

Also, solutions for oxygen exchange that work for small living things may exploit the fact that there is more surface area per unit of interior volume and, so, may not scale well to larger organisms.

Some "economies of scale" exist, also, where some solutions can be harder to make happen in a smaller form, such as the digestive systems of grazing animals.

Composition

Unlike man-made structures, nature prefers composite materials. This allows the same raw materials to serve multiple purposes within a living thing. Living things also have to be able to maintain and repair themselves.

Reproductive Strategy

Some organisms produce many offspring in the hope that a few will survive. This works best in harsh or unstable environments or situations where availability of nourishment is variable. Others produce fewer long-lived descendants, which works best when mortality is low and conditions are relatively stable.

Some plants and animals reproduce infrequently in large numbers. This probably suceeds because predators are not able to increase their numbers quickly enough to take advantage of this overabundance and so some offspring will survive.

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