The Sims 2: Open for Business, the third expansion pack for The Sims 2, allows your sims to operate their own businesses. They are able to manage their staff and develop their talents. Create prized items to bring in top dollar or watch as things go haywire while they are making the next big thing. Players can choose to set up businesses like an electronics store, a restaurant, a beauty salon, a boutique shop, and much more. It was released on March 1, 2006.

This expansion pack also offers robots as sims in the nostalgic form of Servo from The Sims Livin' Large and also robots which help with various housework so that maids and gardeners are not needed. They can water plants, pick up garbage, keep your house safe from robbers, put out fires, and even bring back food when they sense that your sim is hungry.

A special Mascot download (a chicken suit) was available to those who preordered the game.

The Sims 2: Open for Business adds the ability for Sims to own and operate their own business, either in their own home, or by purchasing community lots to manage. Several new gameplay features are added that relate to business running, including a new "Talent Badge" skill system, the ability to craft new items from specialized workbenches, and a bonus system for business owners.

Like the previous two expansion packs, Open for Business introduces a new section of the neighborhood: a shopping district, meant to represent the main street of the area. However, Sim-owned businesses are not restricted to the shopping district, and may be opened in the main neighborhood, although the game manual suggests that shopping district lots are more expensive and higher-traffic.