Times and channels subject to change
| APRIL |
| April 6 | vs Anaheim | 2:05 PM | LOSS 5 - 10 |
| April 7 | vs Anaheim | 7:05 PM | LOSS 7 - 10 |
| April 8 | vs Anaheim | 1:35 PM | LOSS 1 - 5 |
Season Record W0 - L3 Series Record W0 - L1
| April 9 | at Oakland | 7:05 PM | LOSS 6 - 8 |
| April 10 | at Oakland | 1:05 PM | LOSS 1 - 2 |
| April 11 | at Oakland | 1:05 PM | WON 9 - 4 10 innings |
Season Record W1 - L5 Series Record W0 - L2
| April 13 | at Anaheim | 7:05 PM | LOSS 5 - 7 |
| April 14 | at Anaheim | 7:05 PM | LOSS 5 - 6 |
| April 15 | at Anaheim | 7:05 PM | WON 6 - 2 |
Season Record W2 - L7 Series Record W0 - L3
| April 16 | vs Texas | 7:05 PM | LOSS 0 - 5 |
| April 17 | vs Texas | 7:05 PM | WON 4 - 1 |
| April 18 | vs Texas | 1:05 PM | WON 4 - 2 |
Season Record W4 - L8 Series Record W1 - L3
| April 19 | vs Oakland | 7:05 PM | WON 2 - 1 on balk call in 14th inning |
| April 20 | vs Oakland | 7:05 PM | WON 2 - 1 |
| April 21 | vs Oakland | 7:05 PM | LOSS 4 - 7 |
| April 22 | vs Oakland | 1:35 PM | LOSS 2 - 8 |
Season Record W6 - L10 Series Record W1 - L3 - T1
| April 23 | at Texas | 5:05 PM | LOSS 8 - 10 after 2 rain delays |
| April 24 | at Texas | 5:05 PM | LOSS 0 - 3 |
| April 25 | at Texas | 11:05 AM | LOSS 6 - 14 |
Season Record W6 - L13 Series Record W1 - L4 - T1
| April 26 | at Baltimore | RAINED OUT | RESCHEDULED FOR AUGUST 3 |
| April 27 | at Baltimore | 4:05 PM | WON 7 - 5 |
| April 28 | at Baltimore | 4:05 PM | LOSS 1 - 3 |
| April 29 | at Baltimore | 12:05 PM | LOSS 5 - 9 |
Season Record W7 - L15 Series Record W1 - L5 - T1
| April 30 | at Detroit | 4:05 PM | WON 3 - 1 10 innings |
| MAY |
| May 1 | at Detroit | 10:05 AM | LOSS 2 - 4 |
| May 2 | at Detroit | 10:05 AM | WON 12 - 2 |
Season Record W9 - L16 Series Record W2 - L5 - T1
| May 4 | vs Minnesota | 7:05 PM | WON 4 - 3 16 innings |
| May 5 | vs Minnesota | 7:05 PM | LOSS 1 - 5 |
| May 6 | vs Minnesota | 7:05 PM | WON 2 - 1 |
Season Record W11 - L17 Series Record W3 - L5 - T1
| May 7 | vs New York | 7:05 PM | WON 6 - 2 |
| May 8 | vs New York | 7:05 PM | LOSS 0 - 6 |
| May 9 | vs New York | 1:05 PM | LOSS 6 - 7 |
Season Record W12 - L19 Series Record W3 - L6 - T1
| May 11 | at Minnesota | 5:10 PM | LOSS 6 - 7 11 innings |
| May 12 | at Minnesota | 5:10 PM | LOSS 3 - 4 |
| May 13 | at Minnesota | 10:10 AM | LOSS 0 - 1 |
Season Record W12 - L22 Series Record W3 - L7 - T1
| May 14 | at New York | 4:05 PM | LOSS 5 - 9 |
| May 15 | at New York | 10:05 AM | WON 13 - 7 13 innings |
| May 16 | at New York | 10:05 AM | LOSS 1 - 2 |
Season Record W13 - L24 Series Record W3 - L8 - T1
| May 18 | vs Baltimore | 7:05 PM | LOSS 2 - 7 |
| May 19 | vs Baltimore | 7:05 PM | LOSS 2 - 5 |
| May 20 | vs Baltimore | 7:05 PM | WON 11 - 0 |
Season Record W14 - L26 Series Record W3 - L9 - T1
| May 21 | vs Detroit | 7:05 PM | LOSS 0 - 5 |
| May 22 | vs Detroit | 7:05 PM | LOSS 4 - 8 |
| May 23 | vs Detroit | 1:05 PM | WON 3 - 1 |
Season Record W15 - L28 Series Record W3 - L10 - T1
| May 25 | at Cleveland | 4:05 PM | WON 5 - 4 12 innings |
| May 26 | at Cleveland | 4:05 PM | WON 7 - 3 |
| May 27 | at Cleveland | 4:05 PM | LOSS 5 - 9 |
Season Record W17 - L29 Series Record W4 - L10 - T1
| May 28 | at Boston | 4:05 PM | LOSS 4 - 8 |
| May 29 | at Boston | 10:05 AM | WON 5 - 4 |
| May 30 | at Boston | 11:05 AM | LOSS 7 - 9 12 innings |
Season Record W18 - L31 Series Record W4 - L11 - T1
| May 31 | vs Toronto | 7:05 PM | WON 6 - 2 |
| JUNE |
| June 1 | vs Toronto | 7:05 PM | LOSS 5 - 6 |
| June 2 | vs Toronto | 7:05 PM | LOSS 3 - 5 |
Season Record W19 - L33 Series Record W4 - L12 - T1
| June 4 | vs Chicago | 7:05 PM | LOSS 2 - 4 |
| June 5 | vs Chicago | 1:05 PM | WON 4 - 2 |
| June 6 | vs Chicago | 5:05 PM | WON 5 - 4 |
Season Record W21 - L34 Series Record W5 - L12 - T1
| June 7 | vs Houston | 7:05 PM | WON 5 - 0 |
| June 8 | vs Houston | 7:05 PM | LOSS 0-1 |
| June 9 | vs Houston | 7:05 PM | LOSS 0 - 3 |
Season Record W22 - L36 Series Record W5 - L13 - T1
| June 11 | vs Montreal | 7:05 PM | WON 1 - 0 |
| June 12 | vs Montreal | 7:05 PM | WON 3 - 0 |
| June 13 | vs Montreal | 1:05 PM | WON 8 - 1 first series sweep of season |
Season Record W25 - L36 Series Record W6 - L13 - T1
| June 15 | at Milwaukee | 5:05 PM | LOSS 0 - 3 |
| June 16 | at Milwaukee | 5:05 PM | LOSS 1 - 4 |
| June 17 | at Milwaukee | 11:05 AM | WON 6 - 3 |
Season Record W26 - L38 Series Record W6 - L14 - T1
| June 18 | at Pittsburgh | 4:05 PM | WON 5 - 4 |
| June 19 | at Pittsburgh | 4:05 PM | WON 5 - 1 |
| June 20 | at Pittsburgh | 10:35 AM | WON 5 - 4 |
Season Record W29 - L38 Series Record W7 - L14 - T1
| June 22 | at Texas | 5:05 PM | LOSS 2 - 10 |
| June 23 | at Texas | 5:05 PM | LOSS 3 - 6 |
| June 24 | at Texas | 11:05 AM | LOSS 7 - 9 18 innings |
Season Record W29 - L41 Series Record W7 - L15 - T1
| June 25 | vs San Diego | 7:05 PM | LOSS 2 - 3 |
| June 26 | vs San Diego | 7:05 PM | WON 7 - 3 |
| June 27 | vs San Diego | 1:05 PM | LOSS 1 - 5 |
June 27 Traded Freddy Garcia (P) and Ben Davis (C) to Chicago White Sox
Season Record W30 - L43 Series Record W7 - L16 - T1
| June 28 | vs Texas | 7:05 PM | LOSS 5 - 8 |
| June 29 | vs Texas | 7:05 PM | WON 4 - 3 |
| June 30 | vs Texas | 7:05 PM | LOSS 6 - 9 |
| JULY |
| July 1 | vs Texas | 1:35 PM | WON 8 - 4 |
Season Record W32 - L45 Series Record W7 - L16 - T2
| July 2 | at St Louis | 5:10 PM | LOSS 2 - 11 |
| July 3 | at St Louis | 1:05 PM | LOSS 1 - 8 |
| July 4 | at St Louis | 11:15 AM | LOSS 1 - 2 |
Season Record W32 - L48 Series Record W7 - L17 - T2
| July 6 | at Toronto | 4:05 PM | LOSS 6 - 7 |
| July 7 | at Toronto | 4:05 PM | LOSS 4 - 12 |
| July 8 | at Toronto | 4:05 PM | LOSS 8 - 10 |
Season Record W32 - L51 Series Record W7 - L18 - T2
| July 9 | at Chicago | 5:05 PM | LOSS 2 - 6 |
| July 10 | at Chicago | 4:05 PM | LOSS 2 - 3 |
| July 11 | at Chicago | 12:05 PM | LOSS 3 - 4 |
Season Record W32 - L54 Series Record W7 - L19 - T2
| July 13 | ALL STAR GAME AT HOUSTON AL 9 - NL 4 |
July 15 John Olerud(1B)is gone. To be traded or released.
| July 15 | vs Cleveland | 7:05 PM | WON 2 - 1 |
| July 16 | vs Cleveland | 7:05 PM | LOSS 6 - 18 |
| July 17 | vs Cleveland | 7:05 PM | LOSS 5 - 6 |
| July 18 | vs Cleveland | 1:05 PM | WON 7 - 5 |
Season Record W34 - L56 Series Record W7 - L19 - T3
| July 19 | vs Boston | 7:05 PM | WON 8 - 4 11 innings |
| July 20 | vs Boston | 1:35 PM | LOSS 7 - 9 |
Season Record W35 - L57 Series Record W7 - L19 - T4
| July 21 | vs Oakland | 7:05 PM | WON 6 - 5 |
| July 22 | vs Oakland | 7:05 PM | WON 4 - 2 |
Season Record W37 - L57 Series Record W8 - L19 - T4
| July 23 | vs Anaheim | 7:05 PM | LOSS 2 - 8 |
| July 24 | vs Anaheim | 7:05 PM | LOSS 4 - 8 |
| July 25 | vs Anaheim | 1:05 PM | WON 6 - 2 |
Season Record W38 - L59 Series Record W8 - L20 - T4
| July 26 | at Oakland | 7:05 PM | LOSS 5 - 14 |
| July 27 | at Oakland | 7:05 PM | LOSS 3 - 5 |
| July 28 | at Oakland | 12:35 PM | LOSS 2 - 3 |
Season Record W38 - L62 Series Record W8 - L21 - T4
| July 29 | at Anaheim | 7:05 PM | WON 6 - 5 13 innings |
| July 30 | at Anaheim | 7:05 PM | LOSS 5 - 6 |
| July 31 | at Anaheim | 1:05 PM | LOSS 8 - 9 11 innings |
Ended a club record 15 game road losing streak with win on July 29.
| AUGUST |
| August 1 | at Anaheim | 1:05 PM | LOSS 2 - 3 |
Season Record W39 - L65 Series Record W8 - L22 - T4
| August 3 | DOUBLE HITTER | ||
| August 3 | at Baltimore | 10:05 AM | LOSS 7 - 9 |
| August 3 | at Baltimore | 4:05 PM | LOSS 4 - 5 |
| August 4 | at Baltimore | 4:05 PM | LOSS 3 - 6 |
Season Record W39 - L68 Series Record W8 - L23 - T4
| August 5 | at Tampa Bay | 4:15 PM | WON 4 - 2 11 innings |
| August 6 | at Tampa Bay | 4:15 PM | LOSS 1 - 2 10 innings winning run because of obstruction of runner call |
| August 7 | at Tampa Bay | 3:15 PM | WON 5 - 2 |
| August 8 | at Tampa Bay | 10:15 AM | LOSS 1 - 5 |
Season Record W41 - L70 Series Record W8 - L23 - T5
On August 9, Edgar Martinez announced he is going to retire at the end of the season.
| August 10 | vs Minnesota | 7:05 PM | WON 4 - 3 |
| August 11 | vs Minnesota | 7:05 PM | WON 4 - 3 |
| August 12 | vs Minnesota | 1:35 PM | LOSS 3 - 6 |
Season Record W43 - L71 Series Record W9 - L23 - T5
| August 13 | vs New York | 7:05 PM | LOSS 3 - 11 |
| August 14 | vs New York | 1:05 PM | LOSS 4 - 6 |
| August 15 | vs New York | 1:05 PM | WON 7 - 3 |
Season Record W44 - L73 Series Record W9 - L24 - T5
| August 17 | at Kansas City | 5:05 PM | WON 16 - 3 Not a missprint |
| August 18 | at Kansas City | 5:05 PM | LOSS 2 - 3 |
| August 19 | at Kansas City | RAINED OUT | RESCHEDULED FOR AUGUST 3 |
Season Record W45 - L74 Series Record W9 - L24 - T6
| August 20 | at Detroit | 4:05 PM | LOSS 3 - 8 |
| August 21 | at Detroit | 4:05 PM | LOSS 10 - 11 11 innings |
| August 22 | at Detroit | 10:05 AM | WIN 5 - 3 |
Season Record W46 - L76 Series Record W9 - L25 - T6
| August 23 | vs Tampa Bay | 7:05 PM | LOSS 0 - 9 |
| August 24 | vs Tampa Bay | 7:05 PM | LOSS 5 - 6 |
| August 25 | vs Tampa Bay | 7:05 PM | LOSS 5 - 6 |
Season Record W46 - L79 Series Record W9 - L26 - T6
| August 26 | vs Kansas City | 7:05 PM | LOSS 3 - 7 |
| August 27 | vs Kansas City | 7:05 PM | WON 7 - 5 |
| August 28 | DOUBLE HITTER | ||
| August 28 | vs Kansas City | 1:05 PM | WON 9 - 7 |
| August 28 | vs Kansas City | 20 minutes after end of first game | WON 5 - 3 12 innings |
| August 29 | vs Kansas City | 1:05 PM | WON 5 - 4 |
Season Record W50 - L80 Series Record W10 - L26 - T6
| August 31 | at Toronto | 4:05 PM | WON 7 - 5 |
| SEPTEMBER |
| September 1 | at Toronto | 4:05 PM | LOSS 2 - 4 |
| September 2 | at Toronto | 4:05 PM | LOSS 6 - 8 |
Season Record W51 - L82 Series Record W10 - L27 - T6
| September 3 | at Chicago | 5:05 PM | LOSS 5 - 7 |
| September 4 | at Chicago | 4:05 PM | LOSS 7 - 8 |
| September 5 | at Chicago | 12:05 PM | LOSS 2 - 6 |
Season Record W51 - L85 Series Record W10 - L28 - T6
| September 6 | vs Cleveland | 7:05 PM | LOSS 0 - 5 |
| September 8 | vs Cleveland | 7:05 PM | LOSS 5 - 9 |
Season Record W51 - L87 Series Record W10 - L29 - T6
| September 9 | vs Boston | 7:05 PM | WON 7 - 1 |
| September 10 | vs Boston | 7:05 PM | LOSS 2 -13 |
| September 11 | vs Boston | 7:05 PM | LOSS 0 - 9 |
| September 12 | vs Boston | 1:05 PM | WON 2 - 0 |
Season Record W53 - L89 Series Record W10 - L29 - T7
| September 13 | vs Anaheim | 7:05 PM | LOSS 1 - 5 |
| September 14 | vs Anaheim | 7:05 PM | WON 3 - 2 |
| September 15 | vs Anaheim | 7:05 PM | WON 1 - 0 |
| September 16 | vs Anaheim | 7:05 PM | LOSS 1 - 6 |
Season Record W55 - L91 Series Record W10 - L29 - T8
| September 17 | vs Oakland | 7:05 PM | WON 6 - 3 |
| September 18 | vs Oakland | 1:05 PM | LOSS 4 - 7 |
| September 19 | vs Oakland | 1:05 PM | LOSS 1 - 2 |
Season Record W56 - L93 Series Record W10 - L30 - T8
| September 20 | at Anaheim | 7:05 PM | LOSS 2 - 5 |
| September 21 | at Anaheim | 7:05 PM | WON 7 - 3 |
| September 22 | at Anaheim | 7:05 PM | WON 16 - 6 |
Season Record W58 - L94 Series Record W11 - L30 - T8
| September 24 | at Texas | 5:05 PM | WON 8 - 7 |
| September 25 | at Texas | 5:05 PM | LOSS 4 - 5 |
| September 26 | at Texas | 11:05 AM | WON 9 - 0 |
Season Record W60 - L95 Series Record W12 - L30 - T8
| September 27 | at Oakland | 7:05 PM | LOSS 5 - 6 |
| September 28 | at Oakland | 7:05 PM | WON 7 - 2 |
| September 29 | at Oakland | 7:05 PM | WON 4 - 2 |
| September 30 | at Oakland | 12:35 PM | LOSS 2 - 3 |
Season Record W62 - L97 Series Record W12 - L30 - T9
| OCTOBER |
| October 1 | vs Texas | 7:05 PM | WON 8 - 3 |
| October 2 | vs Texas | TBA | LOSS 4 - 10 |
| October 3 | vs Texas | 1:05 PM | LOSS 0 - 3 |
Season Record W63 - L99 Series Record W12 - L31 - T9
On October 1, Ichiro broke single season hit record of 257.
Manager Melvin fired at end of season.