Ampicillin
body weight age 0-7 days age >7 days
<2000 gm 100-200mg/kg/day÷q12h 150-300mg/kg/day÷q8h
>2000 gm 150-300mg/kg/day÷q8h 200-400mg/kg/day÷q6h

Maximum dose for meningitis is 100mg/kg/dose at recommended interval for age

Caffeine UWMC compounds Caffeine Citrate (20mg/mL), this is equal to Caffeine base (10mg/mL)

IV or PO: Loading dose- 20mg/kg
Maintenance dose- 5-7.5mg/kg q24h

Therapeutic range:(5-20mcg/mL) draw 2 hours after 3rd maintenance dose, then on an as needed basis ---------------------------------------------------------------------------- Cefotaxime
Age Dose Interval 0-7 days 100mg/kg/day q12h >7 days 150mg/kg/day q8h >30 days 200mg/kg/day q6h

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Ceftriaxone
Age Dose Interval 0-7 days 50mg/kg/day q24h >7 days 100mg/kg/day q12h

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Chlorothiazide IV or PO: 20-40mg/kg/day÷q12h

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Dexamethasone IV or PO: starting dose-0.5mg/kg/day÷q12h, then taper per 14, 21 or 42 day protocol

GLUCOCORTICOID Equivalent Dose (mg) Gluco- corticoid Potency Mineralo- cortoid Potency Plasma t1/2(min) DOA (hr) Cortisone 25 0.8 2 30 8-12 Hydrocortisone 20 1 2 80-118 8-12 Prednisone 5 4 1 60 18-36 Prednisolone 5 4 1 115-212 18-36 Methylprednisolone 4 5 0 78-188 18-36 Dexamethasone 0.75 20-30 0 110-210 36-54 Betamethasone 0.6-0.75 20-30 0 300+ 36-54

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Enalapril IV: 5-10 µg/kg/dose given q8-24h PO: 0.05-0.1mg/kg/day÷q12-24h

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Erythomycin IV or PO:

Age/Weight Dose Interval <7 days 10mg/kg q12h >7 days 10mg/kg q8h >2000 gm 10mg/kg q6-8h

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Furosemide IV: 0.5-1mg/kg PO: 1-2 mg/kg

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Gentamicin 2.5mg/kg/dose q24h <=34 weeks and <=1250 gm q18h <=34 weeks and >=1250 gm q12h >34 weeks

Therapeutic range Peak:6-12 µg/mL Trough: <2 µg/mL

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HepatitisB Immune Globulin: 0.5mL IM Vaccine: 10mcg/0.5mL IM (EngerixB®)

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Indomethacin Prophylaxis IV: 0.1mg/kg/dose X4 doses (12,24,48 and 72 hours of age)

Treatment q12h X3 doses IV:

Age Dose #1 Dose #2 Dose #3 48 hrs 0.2mg/kg 0.1mg/kg 0.1mg/kg 2-7 days 0.2mg/kg 0.2mg/kg 0.2mg/kg > 7 days 0.2mg/kg 0.25mg/kg 0.25mg/kg

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Lorazepam IV or PO: 0.05-0.1mg/kg/dose q3-6h

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Metoclopramide IV or PO: 0.1mg/kg/dose q6h

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Metolazone PO: 0.2-0.4mg/kg/day RARELY USED AT DOSES <0.4mg/kg/day

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Morphine IV bolus: 0.05-0.1mg/kg q2-4h prn

continuous infusion

Age Dose 0-7 days 10-20mcg/kg/hr <37 weeks or severe hepatic or renal impairment 10mcg/kg/hr >7 days term infant 20-40mcg/kg/hr

Switch from IV to PO Multiply IV by 3 then give 1/2 of the calculated dose and increase as needed REMEMBER you may be converting a continuous IV drip to q3h PO

protocol for NAS (starting dose for consistant scores) Administer orally q3h with feeds:

Finnegan mg/kg/day mL/kg/day 8-10 0.32 0.8 11-13 0.48 1.2 14-16 0.64 1.6 >=17 0.80 2.0

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Pancuronium IV: 0.1mg/kg q1-4h prn

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Phenobarbital IV or PO: Loading dose- 20mg/kg Maintenance dose- 2.5-5mg/kg/day÷q12h Therapeutic range:(15-40 mcg/mL) draw 12 hrs after dose, then follow as needed

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Phenytoin IV: Loading dose:20mg/kg (may ÷ into 2 doses q20min to decrease cardiotoxicity risk) Maintenance dose:5-8mg/kg/day÷q12h Therapeutic range:(10-20mcg/mL) draw levels 8-12hrs after dose

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Ranitidine IV: 2mg/kg/day÷q8-12 PO: 3-4mg/kg/day÷q12 Max. Dose: 5mg/kg/day (IV or PO)

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Surfactant Beractant (Survanta ®): 4mL/kg per ETT q6h x 4 doses in 48 hours(=100mg phospholipid/kg) Colfosceril (Exosurf ®): 5mL/kg per ETT q12h x 3 doses in 48 hours (non-formulary)

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Spironolactone PO: 1-3mg/kg/day÷q8h

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Theophylline Please do not use aminophylline IV or PO: Loading dose: 4-6mg/kg Maintenance dose: 3-6mg/kg/day ÷q8h Therapeutic range:(6-13mcg/mL) draw levels 2hrs after dose

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Vancomycin IV:

Weight/Age Dose Interval <1250 gm 15mg/kg/day q24h 1250-2000 gm 30mg/kg/day q12h >2000 gm or >31 days 30-45mg/kg/day q12h

Therapeutic range Peak: 30-40mcg/mL Trough:5-10mcg/mL

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