Answers

1.   A Study in Scarlet
2.    221B Baker St.
3.    Mrs. Hudson
4.    William Sherlock Scott Holmes
5.    Mycroft
6.    Professor Moriarty
7.    in the toe of a persian slipper
8.    Irene Adler
9.    Colonel Sebastion Moran
10.  doctor
11.  January 6, 1854
12.  The Baker St. Irregulars
13.  Wiggins
14.  Toby
15.  The Strand
16.   Mary Morston
17.  The Sign of Four
18.   swamp adder, most dangerous snake in India
19.  the black pearl of the Borgias
20.  The poisonous root from Africa
21.   In a coffin (under a body)
22.   Riechenbach Falls
23.   3 years
24.   Wessex
25.   Keep bees.