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Gregoria was the daughter of Nicolas de Jesus and Baltazara Alvarez Francisco was born on May 15, 1875 in Kalookan. Her father was a carpenter who served as a gobernadorcillo. Though she was a good student, she discontinued her studies in favor of her two younger brothers.

She and Andres Bonifacio were wed in Roman Catholic rites at the Binondo Church in 1894 and in another set of rites in the Katipunan in July 1893, the very same night when the women’s chapter of the Katipunan was formed. Together with Marina Dizon, Josefa Rizal, Angelica Lopez, Delfina Herbosa and Benita Rodriguez, they were initiated as Katipunan members. She adopted the name Lakambini.

Gregoria and Andres had one child but the child died of small pox and their house in Sta. Cruz was burned. She was designated the keeper of records and the seal of the Katipunan. To escape capture, she often crossed provinces on foot. After Bonifacio’s untimely death, she lived in the mountains of Pasig where she met Julio Nakpil. They were later wed in Quiapo Church in Manila.

They lived in the Quiapo house of Dr. Ariston Bautista, a friend of Filipino propagandists in Spain.

Gregoria died on March 15, 1943, worried because her country was once again under a foreign domination.