if you find a cylinder-specific misfire code such as P0302 (indicating cylinder #2), check the spark plug, plug wire, coil (if it's a DIS or coil-on-plug system), fuel injector and compression to isolate the cause. On the other hand, if you find a random misfire code (P0300), the problem probably is not the ignition system. It's likely a lean fuel mixture caused by a vacuum leak or dirty injectors.