Steroids forum
If the molecule is dissolved in water, this can occur by a simple chemical reaction, yielding the parent drug and a carboxylic acid. steroids forum Epidural steroid injection and neck. For example, if the steroid used is testosterone propionate, testosterone and propionic acid are released. Carboxylic acids are safe and natural in the body in reasonable amounts. It should not be thought that these are strong acids because they are not: they are acids in the same sense that, e. steroids forum Steroid inhale+rs. g. , Vitamin C or lactic acid are acids. Furthermore, the amount of carboxylic acid present at any time is extremely low. steroids forum Bodybuilding clip art. The carboxylic acids do not have any activities of interest. Once the ester group is removed, it has done its job, and the parent drug acts in its normal manner. Besides the simple chemical hydrolysis described above, the esters can be removed by enzymes in the blood called esterases, though water still is required for the reaction. The great majority of hydrolysis occurs with the help of these enzymes or by non-specific reactions with proteins. These reaction cannot take place while the esterified steroid is dissolved in fat. Thus, while the esterified steroids are dissolved in fat, they are protected from hydrolyis, and thus serve as a depot for the drug, giving extended duration of action. What is the significance of the partition coefficient?Differences in partition coefficient seem to account almost fully for the differences between various esters of anabolic steroids, as shown by Chaudry and James. 1,2 To understand their work, though, it is necessary first to consider the methods they used to obtain their data on the anabolic and androgenic effects of the drugs tested. These scientists are not using those terms in the manner which many bodybuilding authors do. The anabolic effect is measured by increase in weight of the levator ani muscle in the rat, and the androgenic effect is measured by increase in weight of the seminal vesicles and prostate. These measurements are neither perfectly indicative of muscle-building value to bodybuilders nor to any particular undesired side effect except perhaps prostate enlargement. Despite the limitations of the method, this was the assay method available. A number of esters of nandrolone were studied, using various single doses, but only the results from a single dose of 1 mg are given here. The results are as follows:Parent Drug Ester # of Carbons Anabolic Effect Anabolic / Androgenic Ratio PRC** (P) x10-3Nandroloneformate 1 1176 13:1 15* acetate 2 1594 11:1 25* propionate 3 1880 10:1 41* butyrate 4 1488 7:1 69 valerate 5 2526 9:1 115* hexanoate 6 3731 9:1 192 heptanoate 7 6559 13:1 269 octanoate 8 5557 15:1 611 nonanoate 9 5080 19:1 455 decanoate 10 7735 25:1 802 undecanoate 11 6576 32:1 1460*extrapolated from P of the butyrate ester** partition ratio coefficientThe anabolic effect was found to be predictable according to the equation:log (anabolic effect) = 7. 33 log P - 0. 636 log P2 -17. 8The accuracy of predictions was quite high (r = 0. 970) and the F value, indicating the statistical significance of the equation, was very high at 61.
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