A.
Structure and Function of the Heart
The
Heart
The heart is a hollow muscular organ with openings into the arteries and from
the veins. In the diagrams of the circulation, the heart is opened out to
show how the blood passes through it. It is about 3 ½ inches wide at
its broadest part, 5 inches long, and 2 ½ inches thick. Its location
is suspended in the chest cavity by the large blood vessels, with its base
resting on the diaphragm. The heart of a healthy 70-kilogram person pumps
about 7,200 liters of blood everyday at a rate of 5 liters per minute. During
short periods of exercise, the rate of the blood pumped increases several
folds.
The heart pumps blood through the circulatory system along two major pathways,
the arteries and veins. The arteries generally carry oxygen-filled blood and
nutrients from the left side of the heart to most body tissues. The veins
generally carry deoxygenated blood and carbon dioxide back to the right side
of the heart. A special network of coronary arteries carries oxygen-rich blood
for use by the heart itself.
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- Structure
of the Heart
- The
heart is divided into a right and left side by a muscular wall called the
septum. Each side is divided horizontally into two sections, for a total of
four chambers: the right and left atria and the right and left ventricles.
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- Valves control
the flow of blood between the chambers of the heart. Atrioventricular valves,
as the name implies, separate the atria from the ventricles:
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The tricuspid valve separates the right atrium from the right ventricle
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The bicuspid or mitral valve separates the left atrium from the left ventricle
Valves
also control the flow of blood between the heart and arteries. Semilunar valves
separate the ventricles from major arteries:
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The pulmonary valve separates the right ventricle from the pulmonary artery
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The aortic valve separates the left ventricle from the aorta
These
valves ensure that blood flows in the correct direction in order for blood
to enter the ventricles from the atria and exit through the large arteries.
The
heart consists mainly of the ff:
1. Atria- small upper chamber
- a.
right atrium- chamber receives deoxygenated blood from the veins
- b.
left atrium- chamber receiving oxygen-rich blood from the lungs which is pumped
into the ventricle
2. Ventricles
- a. right ventricle- cavity
from which blood is pumped to the lungs through pulmonary artery
- b. left ventricle- cavity
from which blood is pumped all around the body by way of the aorta
3. Aorta
- blood
is pumped into the aorta to be circulated throughout the body
- the
largest artery in the body
- carries
oxygenated blood from the left ventricle of the heart and distributes it to
most other parts of the body
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- Function
of the Heart
The heart functions as a pump and is responsible for the circulation of the
blood through the blood vessels. It is responsible for making blood flow through
the blood vessels.
The circulation of the blood starts from the arteries, which carry blood from
the heart. The aorta sends branches to the heart, head and arms, then it gives
out branches to the internal organs. After that, it divides into two arteries
that carry blood to the legs and feet.
The blood reaches the right side of the heart through two big veins: the superior
and inferior vena cava to the right atrium. In the right atrium, most of the
blood passed into the right ventricle relaxes following the previous contraction.
The right atrium then contracts thus push the remaining blood to the right
ventricle.
The contraction of the right ventricle pushes blood against the tricuspid
valve, forcing it closed, and against the pulmonary semilunar valve, forcing
it to open, thus allowing blood to enter the pulmonary trunk. The pulmonary
trunk branches to form pulmonary arteries, which carry blood to each lung.
In the lungs, the blood exchanges carbon dioxide for oxygen through the walls
of many capillaries.
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- Then
blood flows to the left side of the heart in the pulmonary veins. After passing
through the lungs, the blood enters the left atrium through the pulmonary
veins. The blood passing from the left atrium to the left ventricle opens
the bicuspid valve, and the contraction of the atrium completes left ventricular
filling. Contraction of the left ventricle then pushes blood against the bicuspid
valve, closing it, and against the aortic semilunar valve and then goes to
the aorta.
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B.
Pathiophysiology of Cardiovascular Disease
- ATHEROSCLEROSIS
- Commonly called "hardening
of the arteries", it is a progressive disease that causes the arteries to
become narrowed and the walls of the arteries to lose elasticity. Here, arteries
are narrowed and hardened when cholesterol and fats build up in the walls
of the arteries. It can form in any of the arteries in the body.
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- When there is atherosclerosis
in the coronary arteries, the heart muscle does not receive the blood and
nutrients it needs, this leads to angina pectoris, and possibly heart attack.
HYPERTENSION
- Hypertension the medical name
given to high blood pressure. When you have hypertension, the blood vessels
become tight and constricted, forcing your heart to pump harder to move blood
through your body. These changes cause the blood to press on the vessel walls
with greater force. Over time, fatty deposits may build up along the walls
and cause hardening of the arteries. This process is called atherosclerosis.
The heart must work even harder to pump blood through these hardened arteries.
Sometimes blood clots form on these narrow arteries, causing a heart attack
or stroke.
· defined in adult as a blood pressure greater than or equal to 140 Hg systolic
pressure and greater than or equal to 90 mm Hg diastolic pressure.
CORONARY HEART DISEASE
- Coronary heart disease, the
most common type of heart disease in most industrialized countries, is responsible
for nearly 500,000 deaths in the United States yearly. It is caused by atherosclerosis,
the buildup of fatty material called plaque on the inside of the coronary
arteries. Over the course of many years, this plaque narrows the arteries
so that less blood can flow through them and less oxygen reaches the heart
muscle.
The most common symptom of coronary heart disease is angina pectoris, a squeezing
chest pain that may radiate to the neck, jaw, back, and left arm. Angina pectoris
is a signal that blood flow to the heart muscle falls short when extra work
is required from the heart muscle. An attack of angina is typically triggered
by exercise or other physical exertion, or by strong emotions.
Coronary heart disease can also lead to a heart attack. In a heart attack,
part of the heart muscle dies because it is deprived of oxygen. This oxygen
deprivation is also responsible for the crushing chest pain characteristic
of a heart attack.
Coronary heart disease was once thought to affect primarily men, but this
is not the case. The disease affects an equal number of men and women, although
women tend to develop the disease later in life than men do.
Coronary heart disease cannot be cured, but it can often be controlled with
a combination of lifestyle changes and medications. Patients with coronary
heart disease are encouraged to quit smoking, exercise regularly, and eat
a low-fat diet.
CONGENITAL DEFECTS
- About 8 of every 1,000 babies
in the United States are born with a congenital heart defect. One of the most
common abnormalities is a septal defect, an opening between the right
and left atrium or between the right and left ventricle. In babies with these
abnormalities, some of the oxygen-rich blood returning from the lungs is pumped
to the lungs again, placing extra strain on the right ventricle and on the
blood vessels leading to and from the lung.
An infant may be born with several different heart defects, as in the condition
known as Tetralogy of Fallot. In this condition, a combination of four
different heart malformations allows mixing of oxygenated and deoxygenated
blood pumped by the heart. Infants with tetralogy of Fallot are often known
as "blue babies" because of the characteristic bluish tinge of their skin,
a condition caused by lack of oxygen.
ARRYTHMIAS
- Arrhythmias, or abnormal heart
rhythms, arise from problems with the electrical conduction system of the
heart. Arrhythmias can occur in either the atria or the ventricles.
Some people have minor arrhythmias that persist for long periods and are not
dangerous-in fact, they are simply heartbeats that are normal for that particular
person's heart. A temporary arrhythmia can be caused by alcohol, caffeine,
or simply not getting a good night's sleep.
Arrhythmias may involve either abnormally slow or abnormally fast rhythms.
However, the rhythm they generate is slow, often only about 40 beats per minute.
An abnormally slow heartbeat is dangerous if the heart does not pump enough
blood to supply the brain and the rest of the body with oxygen. In this case,
episodes of dizziness, lightheadedness, or fainting may occur. Some types
of abnormally fast heart rhythms are usually not dangerous. Others may be
controlled with medications.
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C.
Risk Factors
Risk
Factors that are Uncontrollable:
- · Increasing
age - About
four out of five people who die of coronary heart disease are age 65 or older.
At older ages, women who have heart attacks are more likely than men are to
die from them within a few weeks.
- · Male
sex (gender) - Men have a greater risk of heart attack than women,
and they have attacks earlier in life. Even after menopause, when women's
death rate from heart disease increases, it's not as great as men's.
- · Heredity
(including race) - Children of parents with heart disease are more
likely to develop it themselves. African Americans have more severe high blood
pressure than whites and a higher risk of heart disease. Heart disease risk
is also higher among Mexican Americans, American Indians, native Hawaiians
and some Asian Americans. This is partly due to higher rates of obesity and
diabetes.
Most people with a strong family history of heart disease have one or more
other risk factors. Just as you can't control your age, sex and race, you
can't control your family history. It's even more important to treat and control
any other risk factors you have.
Risk
Factors You Can Control:
- · Smoking
- Smokers' risk of heart attack is more than twice that of nonsmokers. Cigarette
smoking is the biggest risk factor for sudden cardiac death; smokers have
two to four times the risk of nonsmokers. Smokers who have a heart attack
are more likely to die and die suddenly (within an hour) than are nonsmokers.
Cigarette smoking also acts with other risk factors to greatly increase the
risk for coronary heart disease. People who smoke cigars or pipes seem to
have a higher risk of death from coronary heart disease (and possibly stroke),
but their risk isn't as great as cigarette smokers'. Constant exposure to
other people's smoke - called environmental tobacco smoke, secondhand smoke
or passive smoking - increases the risk of heart disease even for nonsmokers.
- · High
blood cholesterol -
The risk of coronary heart disease rises as blood cholesterol levels increase.
When other risk factors (such as high blood pressure and tobacco smoke) are
present, this risk increases even more. Age, sex, heredity and diet also affect
a person's cholesterol level.
- · High
blood pressure -
High blood pressure increases the heart's workload, causing the heart to enlarge
and weaken over time. It also increases the risk of stroke, heart attack,
kidney failure and congestive heart failure. When high blood pressure exists
with obesity, smoking, high blood cholesterol levels or diabetes, the risk
of heart attack or stroke increases several times.
- · Physical
inactivity - An inactive lifestyle is a risk factor for coronary heart
disease. Regular, moderate-to-vigorous exercise is important in preventing
heart and blood vessel disease. Even moderate-intensity physical activities
are beneficial if done regularly and long term. More vigorous activities are
associated with more benefits. Exercise can help control blood cholesterol,
diabetes and obesity, as well as help lower blood pressure in some people.
- · Obesity
and overweight - People who have excess body fat - especially if a
lot of it is in the waist area - are more likely to develop heart disease
and stroke even if they have no other risk factors. Excess weight increases
the strain on the heart, raises blood pressure and blood cholesterol and triglyceride
levels, and lowers HDL ("good") cholesterol levels. It can also make diabetes
more likely to develop. Many obese and overweight people have difficulty losing
weight. By losing 10 to 20 pounds, you can help lower your heart disease risk.
- · Diabetes
mellitus - Diabetes seriously increases the risk of developing cardiovascular
disease. Even when glucose levels are under control, diabetes greatly increases
the risk of heart disease and stroke. About two-thirds of people with diabetes
die of some form of heart or blood vessel disease. If you have diabetes, it's
critically important to work with your healthcare provider to manage your
diabetes and control any other risk factors you can.
- · Individual response to
stress may be a contributing factor. Some scientists have noted
a relationship between coronary heart disease risk and stress in a person's
life, their health behaviors and socioeconomic status. These factors may affect
established risk factors. For example, people under stress may overeat, start
smoking or smoke more than they otherwise would.
- · Sex
hormones seem
to play a role in heart disease. It's well known that men have more heart
attacks than women do before the age of menopause. Several population studies
show that the loss of natural estrogen as women age may contribute to a higher
risk of heart disease after menopause. If menopause is caused by surgery to
remove the uterus and ovaries, the risk of heart attack rises sharply. If
menopause occurs naturally, the risk rises more slowly. Hormones also affect
blood cholesterol. Female hormones tend to raise HDL ("good") cholesterol
and lower total blood cholesterol. Male hormones do the opposite. If you've
had a natural or surgical menopause, you may be considering estrogen replacement
therapy (ERT) or hormone replacement therapy (HRT). ERT and HRT may increase
a woman's risk of some diseases and health conditions. Your healthcare provider
can give you more information and help you make the best choice.
- · The early forms of birth
control pills, with higher doses of estrogen and progestin , increased
a woman's risk of heart disease and stroke, especially in older women who
smoked heavily. Newer, lower-dose oral contraceptives carry a much lower risk
of cardiovascular disease, except for women who smoke or have high blood pressure.
If a woman taking oral contraceptives has other risk factors (and especially
if she smokes), her risk of developing blood clots and having a heart attack
goes up. It rises even more after age 35. If you take birth control pills,
get yearly medical check-ups of your blood pressure, triglyceride and glucose
levels.
- · Drinking too much alcohol
can raise blood pressure, cause heart failure and lead to stroke. It can contribute
to high triglycerides, cancer and other diseases, and produce irregular heartbeats.
It contributes to obesity, alcoholism, suicide and accidents. The risk of
heart disease in people who drink moderate amounts of alcohol (an average
of one drink for women or two drinks for men per day) is lower than in nondrinkers.
One drink is defined as 1½ fluid ounces (fl oz) of 80-proof spirits (such
as bourbon, Scotch, vodka, gin, etc.), 1 fl oz of 100-proof spirits, 4 fl
oz of wine, or 12 fl oz of beer. It's not recommended that nondrinkers start
using alcohol or that drinkers increase their intake.
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- D.
The Role of Exercise
If exercise doesn’t burn many
calories, and if it doesn’t contribute significantly to causing fat loss,
what role does exercise have in the fat loss process? Exercise provides the
following 6 contributions to a fat loss program. The first three and most
important of these contributions can only be provided by strength training
(weight lifting). Neither aerobic activity, nor any other physical activity
is of any real value. The contributions of exercise are listed in order of
importance.
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- Discriminate Weight Loss
- Increased Basal Metabolism
- Improved Body Shape and Appearance
- Continued Preoccupation
- Depressed Appetite
- Increased Caloric Expenditure
Discriminate Weight
Loss: Weight loss per se’ is
not the objective. What the scale indicates is of no relevance. Fat loss is
what matters. A calorie deficit created in the absence of strength training
will result in the loss of valuable lean tissues (muscle, organ tissue, and
water). Some studies have shown that diet alone without exercise results in
more muscle loss than fat. Aerobic activity also fails to prevent the loss of
muscle. Strength training exercise, and only strength training, causes the body
to selectively lose fat and spare muscle.
Increased Basal
Metabolism: Basal metabolism
describes the amount of energy (calories) your body expends each day for all
its basic life sustaining functions. Essentially, it is the base level of energy
expenditure to sustain life. It does not include extra calories expended during
physical activity. In addition to preventing a loss, strength training causes
an increase in lean muscle tissue. Muscles have a high energy requirement to
sustain them. Therefore, as muscle tissue is increased, basal metabolism increases.
The body then requires additional calories each day to support basic physiological
functions. This allows a higher calorie intake without fat gain, a higher calorie
intake that still results in fat loss, and a higher calorie intake for fat maintenance.
Improved Shape
and Appearance: When muscles
become stronger they become firmer and possess better muscle "tone". Their shape,
contour, and definition also improves. All these attributes enhance overall
body shape and appearance.
Continued Preoccupation:
You can’t eat and exercise
and/or perform physical activity at the same time. Therefore, by preoccupying
you, exercise can assist in prevention of excess food consumption.
Depressed Appetite:
Physical activity, especially exercise, depresses appetite. However, this factor
is of limited value due to its temporary effect. Hunger returns after the body
has recovered from the bout of exercise.
If you develop a craving for food,
get up and take a walk, clean the house, or wash the car. These activities do
not qualify as exercise, nor do they burn much in the way of extra calories,
but they will depress your appetite and keep you preoccupied.
Increased Caloric
Expenditure: Increased caloric
expenditure is by far the slightest and least important contribution of exercise
to a fat loss program. Its contribution is so insignificant that it hardly deserves
mention. Ironically, increased caloric expenditure receives the most attention
by the press, health care professionals, and the general public. This is indicative
of how out of touch with reality people are in regard to the facts of fat loss.
It has already been illustrated
how few extra calories are expended by exercise. So few that you should not
even consider them in your program. Far better, more time efficient results
are achieved by restricting calorie intake and performing two brief, but intense,
strength training workouts each week.
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So...what
is fat, really???
Fat is a major
source of calories or energy. Fat improves the taste and odor of foods and gives
a feeling of fullness. Fats form the structures in our bodies, including muscles,
nerves, membranes and blood vessels and are essential for the absorption of
fat-soluble vitamins A, D, E and K in the body .
Although some
fat in the diet is necessary, too much fat can lead to heart disease, obesity
and other health problems. There are three kinds of fat: saturated fat, polyunsaturated
fat and monounsaturated fat. Fats in the diet may be of animal (saturated) or
vegetable (unsaturated) origin. Examples of fat in the diet are gravy, bacon,
margarine, butter, cream, salad dressings and nuts. Meats and some milk products
also contain significant amounts of fat. The guidelines recommended by the American
Heart Association and the Surgeon General's Office suggest that fat should contribute
no more than 30% of total calories. For those adults with heart disease a diet
of 20 percent or even 10 percent of calories from fat is advised. The fat we
eat is saturated and unsaturated. These terms refer to the chemical structure
of the fat molecules. A low total fat intake, with the majority of fat from
unsaturated sources, appears to lower blood cholesterol levels. Too much of
any of these fats will increase dietary fat intake, and excess body fat may
increase cholesterol levels and the potential to increase body fat.
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