Kapás L, Shibata
M, Kimura M, Krueger JM
Am. J. Physiol. 1994 266(1 Pt 2):R151-7 The effects of N omega-nitro-L-arginine
methyl ester (L-NAME), an inhibitor of nitric oxide synthesis, on spontaneous
and interleukin-1 (IL-1)-induced sleep were examined in rabbits. Animals
were injected intracerebroventricularly or intravenously during the light
phase with vehicle, L-NAME, IL-1, or the combination of L-NAME and IL-1.
Injection of L-NAME (5 mg icv and 100 mg/kg iv) suppressed both non-rapid
eye movement sleep (NREMS) and rapid eye movement sleep (REMS) for 4-6
h. The sleep-suppressive effects are unlikely due to pressor responses
to L-NAME because administration of L-NAME (5 mg icv) produced only a transient
(3-4 min) slight increase in systemic blood pressure. Injection of IL-1
(20 ng icv) elicited fever, suppressed REMS, and increased NREMS for 6
h. NREMS was suppressed for 3 h after the combined intracerebroventricular
injections of 5 mg L-NAME and 20 ng IL-1 and was elevated during postinjection
hours 4-6. Administration of IL-1 (30 ng/kg iv) increased NREMS and brain
temperature for 2 h. After the combined injection of IL-1 and L-NAME (100
mg/kg), NREMS was significantly suppressed during postinjection hours 1-5.
It is not known whether the interactions
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