Gram-Staining Procedure | ![]() |
As you have done previously, fix your bacterial cells on a microscope slide. Again, if your source of cells is a colony from a petri dish, you will need to thin out the cells to get good staining and subsequent visualization.
Stain your slide with crystal violet (the primary stain). Leave on for 1-3 minutes; expose for a longer time (i.e. 3 min.) the first time and modify your procedure as needed thereafter.
Rinse with water, being careful not to "flood" the slide. Rinse until the water runs clear.
Add Gram's iodine for 3-4 minutes.
Decolorize with alcohol (95% to 100% EtOH, typically) again being sure not to "flood" your cells, washing away the unbound crystal violet and iodine.
Counter-stain with safranin for 3-4 minutes.
Rinse with water; again, ne flood pas.
Carefully, blot dry
Observe under the microscope using, ultimately, oil immersion. Record your results.