Introduced in 1998

Supporting Research: Altogether 11 clinical trials have been conducted in which obese and overweight people went on a reduced calorie diet and were randomly assigned to take Meridia or a placebo. The trials lasted for 12 to 52 weeks. After one year, participants taking 10 mg a day of Meridia lost ten pounds, and those taking 15 mg of Meridia lost 14 pounds. The people solely on the reduced calorie diet lost 3 1/2 pounds. Weight was regained after Meridia was discontinued.

How it works: Meridia acts somewhat like an antidepressant. It decreases the appetite by blocking reuptake of nerve transmitters (norepinephrine, serotonin and dopamine) in brain synap

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