he interaction between pimozide and sertraline was brought to light in the "Phase 1 Open Study Designed to Determine the Potential Interaction of Sertra line With Cisapride or Pimozide in Healthy Male and Female Subjects." In this controlled study, a standard 2-mg dose of pimozide was administered to participants already receiving 200 mg daily of sertraline. When combined in this way, absorption of pimozide increased by an average of 40%.

Despite the increased absorption, the study found no changes in heart function as measured by electrocardiogram. However, since the highest recommended dose of pimozide is 10 mg, and at this dosing it has not been studied in combination with sertraline, the effect on heart function at doses over 2 mg are unknown.

 

 

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